2P5X

Crystal structure of Maf domain of human N-acetylserotonin O-methyltransferase-like protein

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2p5xa_	Alpha and beta proteins (a/b)	Anticodon-binding domain-like	ITPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2p5xb_	Alpha and beta proteins (a/b)	Anticodon-binding domain-like	ITPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Maf-like	8017416	4000520	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ITPase-like	8057717	3000497	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ITPase-like	8057717	3000497	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Maf	e2p5xA1	A: a/b three-layered sandwiches	X: ITPase-like (From Topology)	H: ITPase-like (From Topology)	T: ITPase-like	F: Maf	ECOD (1.6)
B	Maf	e2p5xB1	A: a/b three-layered sandwiches	X: ITPase-like (From Topology)	H: ITPase-like (From Topology)	T: ITPase-like	F: Maf	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.950.10	Alpha Beta	Alpha-Beta Complex	Maf protein		CATH (4.3.0)
B	3.90.950.10	Alpha Beta	Alpha-Beta Complex	Maf protein		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02545	Maf-like protein (Maf)	Maf-like protein	Maf is a putative inhibitor of septum formation [1] in eukaryotes, bacteria, and archaea.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	N-acetylserotonin O-methyltransferase-like protein	pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity UTP diphosphatase activity O-methyltransferase activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity dTTP diphosphatase activity	methylation metabolic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process cellular process small molecule metabolic process methylation metabolic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process cellular process small molecule metabolic process phosphorus metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029001	Inosine triphosphate pyrophosphatase-like	Homologous Superfamily
A, B	IPR001077	O-methyltransferase domain	Domain
A, B	IPR016461	O-methyltransferase COMT-type	Family
A, B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR031725	Acetylserotonin O-methyltransferase, dimerisation domain	Domain
A, B	IPR003697	Nucleoside triphosphate pyrophosphatase Maf-like protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O95671	acute myeloid leukemia astrocytic tumor malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm tuberculosis Acute Myeloid Leukemia (AML-M2) cutaneous lupus erythematosus medulloblastoma psoriasis intellectual disability ovarian cancer subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.