2P32

Crystal structure of the C-terminal 10 kDa subdomain from C. elegans Hsp70

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Heat shock protein 70kD (HSP70) C-terminal subdomain	8082794	4000583	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Heat shock protein 70kD (HSP70) C-terminal subdomain	8082795	3000668	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Heat shock protein 70kD (HSP70) C-terminal subdomain	8082795	3000668	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Heat shock protein 70kD (HSP70) C-terminal subdomain	8082795	3000668	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Heat shock protein 70kD (HSP70) C-terminal subdomain	8082795	3000668	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Heat shock protein 70kD (HSP70) C-terminal subdomain	8082795	3000668	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Heat shock protein 70kD (HSP70) C-terminal subdomain	8082795	3000668	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2p32A1	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Heat shock protein 70kD (HSP70), C-terminal subdomain (From Topology)	T: Heat shock protein 70kD (HSP70), C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e2p32B1	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Heat shock protein 70kD (HSP70), C-terminal subdomain (From Topology)	T: Heat shock protein 70kD (HSP70), C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e2p32C1	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Heat shock protein 70kD (HSP70), C-terminal subdomain (From Topology)	T: Heat shock protein 70kD (HSP70), C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e2p32D1	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Heat shock protein 70kD (HSP70), C-terminal subdomain (From Topology)	T: Heat shock protein 70kD (HSP70), C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e2p32E1	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Heat shock protein 70kD (HSP70), C-terminal subdomain (From Topology)	T: Heat shock protein 70kD (HSP70), C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e2p32F1	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Heat shock protein 70kD (HSP70), C-terminal subdomain (From Topology)	T: Heat shock protein 70kD (HSP70), C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1270.10	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
B	1.20.1270.10	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
C	1.20.1270.10	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
D	1.20.1270.10	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
E	1.20.1270.10	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
F	1.20.1270.10	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00012	Hsp70 protein (HSP70)	Hsp70 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Heat shock 70 kDa protein A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity protein binding heat shock protein binding protein folding chaperone ATP-dependent protein folding chaperone	protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process multicellular organismal process determination of adult lifespan chaperone cofactor-dependent protein refolding chaperone-mediated protein folding 'de novo' protein folding 'de novo' post-translational protein folding cellular localization transport intracellular transport establishment of localization vesicle-mediated transport endosomal transport localization cytosolic transport retrograde transport, endosome to Golgi establishment of localization in cell response to stimulus response to stress response to heat response to abiotic stimulus response to temperature stimulus	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR029048	Heat shock protein 70kD, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018181	Heat shock protein 70, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR013126	Heat shock protein 70 family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.