2P1N

Mechanism of Auxin Perception by the TIR1 Ubiqutin Ligase

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01466,PF03931	e2p1nA1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF01466,PF03931	ECOD (1.6)
D	PF01466,PF03931	e2p1nD1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF01466,PF03931	ECOD (1.6)
B	PF18791	e2p1nB2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF18791	ECOD (1.6)
B	PF18511	e2p1nB1	A: alpha arrays	X: F-box domain (From Topology)	H: F-box domain (From Topology)	T: F-box domain	F: PF18511	ECOD (1.6)
E	PF18791	e2p1nE2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF18791	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)
D	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)
B	1.20.1280.50	Mainly Alpha	Up-down Bundle	Monooxygenase		CATH (4.3.0)
B	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
E	1.20.1280.50	Mainly Alpha	Up-down Bundle	Monooxygenase		CATH (4.3.0)
E	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF01466	Skp1 family, dimerisation domain (Skp1)	Skp1 family, dimerisation domain	-	Domain
B, E	PF18791	Transport inhibitor response 1 protein domain (Transp_inhibit)	Transport inhibitor response 1 protein domain	-	Repeat
B, E	PF00646	F-box domain (F-box)	F-box domain	This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; Pfam:PF00560 and Pfam:PF07 ...	This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; Pfam:PF00560 and Pfam:PF07723) and the WD repeat (Pfam:PF00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression [1-2].	Domain
C, F	PF02309	AUX/IAA family (AUX_IAA)	AUX/IAA family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	SKP1-like protein 1A	-	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular response to stimulus response to organic substance regulation of cellular process response to stimulus signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus ethylene-activated signaling pathway response to hormone response to ethylene signal transduction cellular response to organic substance cellular response to hormone stimulus regulation of biological process phosphorelay signal transduction system cellular response to ethylene stimulus response to endogenous stimulus biological regulation cellular response to chemical stimulus response to chemical cellular process response to auxin cell cycle chromosome segregation cell cycle process cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization response to lipid response to jasmonic acid response to fatty acid response to oxygen-containing compound cellular response to jasmonic acid stimulus jasmonic acid mediated signaling pathway cellular response to oxygen-containing compound cellular response to fatty acid cellular response to lipid regulation of DNA recombination negative regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process DNA recombination regulation of macromolecule metabolic process DNA metabolic process nucleic acid metabolic process negative regulation of DNA recombination organic cyclic compound metabolic process negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal auxin-activated signaling pathway cellular response to auxin stimulus	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle phragmoplast cytosol cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle phragmoplast cytosol cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex transferase complex intracellular protein-containing complex nucleus
B, E	TRANSPORT INHIBITOR RESPONSE 1 protein	auxin binding binding hormone binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity molecular transducer activity signaling receptor activity auxin receptor activity ion binding auxin binding binding hormone binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity molecular transducer activity signaling receptor activity auxin receptor activity ion binding inositol hexakisphosphate binding alcohol binding anion binding small molecule binding	cellular process cell cycle developmental process multicellular organismal process plant organ development floral whorl development reproductive system development reproductive process stamen development flower development developmental process involved in reproduction reproductive shoot system development multicellular organism development anatomical structure development cellular process cell cycle developmental process multicellular organismal process plant organ development floral whorl development reproductive system development reproductive process stamen development flower development developmental process involved in reproduction reproductive shoot system development multicellular organism development anatomical structure development reproductive structure development shoot system development post-embryonic development phyllome development androecium development system development floral organ development gametophyte development pollen maturation developmental maturation pollen development cellular response to stimulus response to organic substance regulation of cellular process response to stimulus signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus ethylene-activated signaling pathway response to hormone response to ethylene signal transduction cellular response to organic substance cellular response to hormone stimulus regulation of biological process phosphorelay signal transduction system cellular response to ethylene stimulus response to endogenous stimulus biological regulation cellular response to chemical stimulus response to chemical root morphogenesis post-embryonic root morphogenesis post-embryonic plant organ morphogenesis post-embryonic plant morphogenesis plant organ morphogenesis post-embryonic root development anatomical structure morphogenesis lateral root morphogenesis anatomical structure formation involved in morphogenesis lateral root development post-embryonic plant organ development plant organ formation lateral root formation root development root system development response to auxin organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal auxin-activated signaling pathway cellular response to auxin stimulus cellular response to nutrient levels response to nutrient levels cellular response to phosphate starvation cellular response to stress response to stress response to starvation cellular response to starvation defense response	cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex transferase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity
C, F	Auxin-responsive protein IAA7	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription regulator activity DNA-binding transcription factor activity	response to stimulus response to abiotic stimulus tropism response to external stimulus gravitropism response to gravity response to acid chemical response to stress response to chemical response to oxygen-containing compound response to water response to water deprivation response to inorganic substance auxin-activated signaling pathway response to stimulus response to abiotic stimulus tropism response to external stimulus gravitropism response to gravity response to acid chemical response to stress response to chemical response to oxygen-containing compound response to water response to water deprivation response to inorganic substance auxin-activated signaling pathway cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process signaling response to endogenous stimulus biological regulation hormone-mediated signaling pathway cellular response to auxin stimulus cell communication response to auxin cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone cellular process cellular response to organic substance signal transduction cellular response to hormone stimulus response to wounding response to lipid response to jasmonic acid response to fatty acid	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR016073	SKP1 component, POZ domain	Domain
A, D	IPR036296	SKP1-like, dimerisation domain superfamily	Homologous Superfamily
A, D	IPR001232	S-phase kinase-associated protein 1-like	Family
A, D	IPR016072	SKP1 component, dimerisation	Domain
A, D	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
A, D	IPR016897	S-phase kinase-associated protein 1	Family
B, E	IPR036047	F-box-like domain superfamily	Homologous Superfamily
B, E	IPR041567	COI1, F-box	Domain
B, E	IPR001810	F-box domain	Domain
B, E	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
B, E	IPR006553	Leucine-rich repeat, cysteine-containing subtype	Repeat
B, E	IPR041101	Transport inhibitor response 1 domain	Domain
C, F	IPR003311	AUX/IAA protein	Family
C, F	IPR033389	AUX/IAA domain	Domain
C, F	IPR000270	PB1 domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.