2P1L

Structure of the Bcl-XL:Beclin 1 complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2p1la_	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Bcl-2 inhibitors of programmed cell death	Bcl-2 inhibitors of programmed cell death	Apoptosis regulator Bcl-xL	human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2p1lc_	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Bcl-2 inhibitors of programmed cell death	Bcl-2 inhibitors of programmed cell death	Apoptosis regulator Bcl-xL	human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2p1le_	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Bcl-2 inhibitors of programmed cell death	Bcl-2 inhibitors of programmed cell death	Apoptosis regulator Bcl-xL	human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2p1lg_	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Bcl-2 inhibitors of programmed cell death	Bcl-2 inhibitors of programmed cell death	Apoptosis regulator Bcl-xL	human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00452,PF02180	e2p1lA1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452,PF02180	ECOD (1.6)
C	PF00452,PF02180	e2p1lC1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452,PF02180	ECOD (1.6)
E	PF00452,PF02180	e2p1lE1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452,PF02180	ECOD (1.6)
G	PF00452,PF02180	e2p1lG1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452,PF02180	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (utative)
C	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (utative)
E	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (utative)
G	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF02180	Bcl-2 homology region 4 (BH4)	Bcl-2 homology region 4	-	Family
A, C, E, G	PF00452	Apoptosis regulator proteins, Bcl-2 family (Bcl-2)	Apoptosis regulator proteins, Bcl-2 family	-	Family
B, D, F, H	PF15285	Beclin-1 BH3 domain, Bcl-2-interacting (BH3)	Beclin-1 BH3 domain, Bcl-2-interacting	The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Apoptosis regulator Bcl-X	death domain binding protein binding binding BH3 domain binding BH domain binding protein domain specific binding identical protein binding protein heterodimerization activity protein dimerization activity protein homodimerization activity kinase binding enzyme binding protein kinase binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation cell population proliferation mononuclear cell proliferation dendritic cell proliferation cellular process leukocyte proliferation fertilization cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process signal transduction regulation of biological process regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of growth growth regulation of anoikis negative regulation of anoikis anoikis cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to endogenous stimulus response to nitrogen compound response to alkaloid cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance cellular response to alkaloid regulation of localization apoptotic mitochondrial changes localization regulation of biological quality positive regulation of membrane permeability negative regulation of cellular component organization establishment of localization regulation of organelle organization regulation of membrane permeability negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrial membrane permeability involved in apoptotic process regulation of cellular component organization negative regulation of mitochondrial membrane permeability transport mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization cellular component organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability cellular component organization or biogenesis regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization regulation of transport organelle organization negative regulation of organelle organization regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrion organization negative regulation of membrane permeability mitochondrial outer membrane permeabilization embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development apoptotic process in bone marrow cell dendritic cell apoptotic process leukocyte apoptotic process signal transduction in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand negative regulation of reproductive process regulation of reproductive process regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process female gonad development female sex differentiation development of primary female sexual characteristics ovarian follicle development regulation of release of cytochrome c from mitochondria negative regulation of release of cytochrome c from mitochondria release of cytochrome c from mitochondria cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to amino acid regulation of leukocyte proliferation positive regulation of cell population proliferation positive regulation of biological process regulation of cell population proliferation positive regulation of leukocyte proliferation positive regulation of mononuclear cell proliferation regulation of mononuclear cell proliferation positive regulation of cellular process cellular developmental process cell development programmed cell death involved in cell development cell differentiation ectopic germ cell programmed cell death negative regulation of cellular catabolic process negative regulation of catabolic process catabolic process cellular metabolic process negative regulation of metabolic process autophagy regulation of cellular metabolic process regulation of catabolic process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process metabolic process process utilizing autophagic mechanism regulation of metabolic process response to ketone response to cycloheximide response to alcohol response to oxygen-containing compound response to organic cyclic compound negative regulation of intracellular signal transduction regulation of cellular response to stress regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of intrinsic apoptotic signaling pathway DNA damage response biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to external biotic stimulus response to virus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of signal transduction in absence of ligand regulation of extrinsic apoptotic signaling pathway in absence of ligand protein localization cellular localization regulation of protein localization negative regulation of protein localization to plasma membrane cellular macromolecule localization regulation of protein localization to membrane negative regulation of protein localization protein localization to cell periphery protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization macromolecule localization negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane cellular process involved in reproduction in multicellular organism germ cell development cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus response to gamma radiation regulation of mitochondrial membrane potential regulation of membrane potential import into cell endocytosis vesicle-mediated transport regulation of response to endoplasmic reticulum stress negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway response to endoplasmic reticulum stress negative regulation of response to endoplasmic reticulum stress response to cytokine neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process negative regulation of execution phase of apoptosis regulation of execution phase of apoptosis execution phase of apoptosis regulation of developmental process negative regulation of developmental process regulation of leukocyte apoptotic process negative regulation of dendritic cell apoptotic process negative regulation of leukocyte apoptotic process regulation of dendritic cell apoptotic process epithelial cell proliferation hepatocyte apoptotic process epithelial cell apoptotic process	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol mitochondrial membrane mitochondrion organelle outer membrane bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane synapse intracellular vesicle transport vesicle membrane presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle organelle inner membrane mitochondrial inner membrane centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex Bcl-2 family protein complex membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen endoplasmic reticulum
B, D, F, H	Beclin 1	phosphatidylinositol 3-kinase binding protein binding binding protein-macromolecule adaptor activity molecular adaptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding identical protein binding GTPase binding kinase binding protein kinase binding	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response response to chemical response to xenobiotic stimulus p38MAPK cascade intracellular signal transduction intracellular signaling cassette MAPK cascade cellular response to inorganic substance cellular response to metal ion response to aluminum ion cellular response to aluminum ion response to inorganic substance cellular response to chemical stimulus response to metal ion cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process cellular component disassembly catabolic process macroautophagy protein-containing complex organization autophagy protein-containing complex disassembly cellular catabolic process cellular component organization autophagosome maturation cellular component organization or biogenesis process utilizing autophagic mechanism regulation of cellular metabolic process regulation of catabolic process regulation of autophagy regulation of macroautophagy regulation of cellular catabolic process regulation of metabolic process cell division cellular response to nutrient levels response to nutrient levels cellular response to stress response to starvation cellular response to glucose starvation cellular response to starvation establishment of organelle localization cellular localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation cell cycle chromosome segregation cell cycle process mitotic nuclear division organelle fission chromosome organization sister chromatid segregation establishment of localization organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation establishment of chromosome localization apoptotic process cell death programmed cell death response to mitochondrial depolarisation response to iron(II) ion response to iron ion negative regulation of programmed cell death negative regulation of cellular process negative regulation of biological process regulation of programmed cell death regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division regulation of cell cycle negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of cellular metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process JNK cascade muscle hypertrophy regulation of muscle adaptation multicellular organismal process system process positive regulation of cardiac muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway regulation of intracellular signal transduction intrinsic apoptotic signaling pathway positive regulation of cellular process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction positive regulation of apoptotic process apoptotic signaling pathway regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus cellular defense response response to organic substance response to nutrient response to oxygen-containing compound response to vitamin E response to vitamin response to organic cyclic compound positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of vacuole organization autophagosome organization positive regulation of cellular metabolic process cellular component biogenesis positive regulation of metabolic process cellular component assembly positive regulation of autophagosome assembly positive regulation of macroautophagy positive regulation of autophagy autophagosome assembly organelle assembly vacuole organization positive regulation of cellular component biogenesis regulation of autophagosome assembly regulation of vacuole organization regulation of cellular component biogenesis regulation of organelle organization positive regulation of catabolic process regulation of organelle assembly positive regulation of cellular catabolic process positive regulation of organelle assembly cellular response to amino acid starvation response to amino acid starvation defense response to virus response to virus receptor catabolic process macromolecule catabolic process receptor metabolic process macromolecule metabolic process organic substance catabolic process organonitrogen compound metabolic process amyloid-beta metabolic process amide metabolic process late endosome to vacuole transport transport vacuolar transport intracellular transport vesicle-mediated transport protein-containing complex assembly negative regulation of lysosome organization negative regulation of cellular component organization lytic vacuole organization lysosome organization negative regulation of organelle organization regulation of lysosome organization cellular response to nitrogen levels cellular response to nitrogen starvation negative regulation of apoptotic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction response to copper ion cellular response to copper ion cellular response to oxidative stress cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species response to lead ion cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway SMAD protein signal transduction enzyme-linked receptor protein signaling pathway negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of cellular catabolic process negative regulation of organelle assembly negative regulation of autophagosome assembly negative regulation of catabolic process negative regulation of macroautophagy negative regulation of autophagy protein localization establishment of protein localization nitrogen compound transport protein targeting establishment of protein localization to vacuole lysosomal transport protein targeting to lysosome cellular macromolecule localization protein targeting to vacuole organic substance transport protein localization to vacuole protein localization to lysosome establishment of protein localization to organelle protein transport protein localization to organelle macromolecule localization intracellular protein transport cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to epidermal growth factor stimulus response to epidermal growth factor response to growth factor suppression by virus of host autophagy modulation by virus of host autophagy modulation by symbiont of host process viral process modulation by virus of host process modulation of process of another organism biological process involved in interaction with host modulation by virus of host cellular process biological process involved in symbiotic interaction mitophagy organelle disassembly autophagy of mitochondrion mitochondrion organization endosomal transport vesicle-mediated transport between endosomal compartments early endosome to late endosome transport membrane organization import into cell engulfment of apoptotic cell phagocytosis, engulfment membrane invagination phagocytosis apoptotic cell clearance endocytosis plasma membrane invagination cellular response to oxygen levels cellular response to decreased oxygen levels cellular response to oxygen-glucose deprivation response to oxygen-glucose deprivation developmental process cellular developmental process cell development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development system development regulation of localization regulation of attachment of mitotic spindle microtubules to kinetochore attachment of mitotic spindle microtubules to kinetochore regulation of chromosome organization regulation of mitotic sister chromatid segregation regulation of chromosome segregation regulation of attachment of spindle microtubules to kinetochore positive regulation of cell cycle process positive regulation of chromosome segregation attachment of spindle microtubules to kinetochore positive regulation of attachment of spindle microtubules to kinetochore positive regulation of cell cycle regulation of sister chromatid segregation positive regulation of attachment of mitotic spindle microtubules to kinetochore regulation of metaphase plate congression	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol phosphatidylinositol 3-kinase complex, class III, type II protein-containing complex catalytic complex membrane membrane protein complex transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class III extrinsic component of membrane intracellular anatomical structure cytoplasm cellular anatomical entity cytosol phosphatidylinositol 3-kinase complex, class III, type II protein-containing complex catalytic complex membrane membrane protein complex transferase complex phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups phosphatidylinositol 3-kinase complex, class III extrinsic component of membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle organelle vacuole autophagosome intracellular membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment endomembrane system trans-Golgi network endosome membrane endosome intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane phagophore assembly site phagocytic vesicle endocytic vesicle mitochondrial membrane mitochondrion cytoplasmic side of membrane organelle outer membrane cytoplasmic side of mitochondrial outer membrane side of membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane phosphatidylinositol 3-kinase complex, class III, type I nucleus membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
A, C, E, G	IPR004725	Apoptosis regulator, Bcl-2/ BclX	Family
A, C, E, G	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4	Domain
A, C, E, G	IPR002475	Bcl2-like	Family
A, C, E, G	IPR020731	Apoptosis regulator, Bcl-2, BH4 motif, conserved site	Conserved Site
A, C, E, G	IPR013279	Apoptosis regulator, Bcl-X	Family
A, C, E, G	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site	Conserved Site
A, C, E, G	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Conserved Site
A, C, E, G	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
A, C, E, G	IPR026298	Bcl-2 family	Family
A, C, E, G	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
B, D, F, H	IPR038274	Atg6/Beclin C-terminal domain superfamily	Homologous Superfamily
B, D, F, H	IPR029318	Beclin-1, BH3 domain	Domain
B, D, F, H	IPR040455	Atg6, BARA domain	Domain
B, D, F, H	IPR007243	Atg6/Beclin	Family
B, D, F, H	IPR041691	Atg6/beclin, coiled-coil domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: Q07817	plasma cell myeloma liver disease myocardial infarction Liver Neoplasms, Experimental type 2 diabetes mellitus cryptorchidism follicular thyroid adenoma microcystic adenoma erectile dysfunction head and neck cancer adenoma hearing loss disorder papillary adenoma amyotrophic lateral sclerosis type 1 sarcomatoid carcinoma plasma cell myeloma liver disease myocardial infarction Liver Neoplasms, Experimental type 2 diabetes mellitus cryptorchidism follicular thyroid adenoma microcystic adenoma erectile dysfunction head and neck cancer adenoma hearing loss disorder papillary adenoma amyotrophic lateral sclerosis type 1 sarcomatoid carcinoma carcinoma chronic obstructive pulmonary disease malignant ependymoma malignant tumor of neck gastric neoplasm medulloblastoma head and neck neoplasm hematologic disease pancreatic intraductal papillary-mucinous neoplasm intestinal disease psoriasis B-cell chronic lymphocytic leukemia cancer MALT lymphoma glioblastoma myopathy acute myeloid leukemia oligodendroglioma hepatocellular carcinoma pancreatic neoplasm hereditary diffuse gastric adenocarcinoma plasma cell neoplasm intracerebral hemorrhage sarcoidosis lung benign neoplasm undifferentiated carcinoma lymphatic system disease malignant pancreatic neoplasm gastric cancer maturity-onset diabetes of the young myeloid neoplasm neoplasm of neck ovarian cancer prostate disease atypical teratoid rhabdoid tumor large cell medulloblastoma breast disease toxic encephalopathy lung disease
B, D, F, H	Pharos: Q14457	status epilepticus myocardial infarction Lewy body dementia malignant colon neoplasm Status Epilepticus, Subclinical benign colon neoplasm lung benign neoplasm pancreatic intraductal papillary-mucinous carcinoma cancer osteosarcoma colonic neoplasm neurodegenerative disease ovarian cancer schizophrenia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.