2P0M

Revised structure of rabbit reticulocyte 15S-lipoxygenase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2p0ma1	All alpha proteins	Lipoxigenase	Lipoxigenase	Animal lipoxigenases	automated matches	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
A	d2p0ma2	All beta proteins	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	automated matches	automated matches	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
B	d2p0mb1	All alpha proteins	Lipoxigenase	Lipoxigenase	Animal lipoxigenases	automated matches	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
B	d2p0mb2	All beta proteins	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	automated matches	automated matches	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Lipoxygenase N-terminal domain-like	8022918	4002389	SCOP2 (2022-06-29)
A	SCOP2 Family	Lipoxygenase catalytic domain-like	8022917	4001373	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8035298	3001168	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Lipoxygenase	8035297	3001410	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Lipoxygenase	8035297	3001410	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8035298	3001168	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PLAT	e2p0mA1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT	ECOD (1.6)
A	Lipoxygenase	e2p0mA2	A: alpha bundles	X: Lipoxygenase (From Topology)	H: Lipoxygenase (From Topology)	T: Lipoxygenase	F: Lipoxygenase	ECOD (1.6)
B	PLAT	e2p0mB1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT	ECOD (1.6)
B	Lipoxygenase	e2p0mB2	A: alpha bundles	X: Lipoxygenase (From Topology)	H: Lipoxygenase (From Topology)	T: Lipoxygenase	F: Lipoxygenase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.60.20	Mainly Beta	Sandwich	Lipoxygenase-1	PLAT/LH2 domain	CATH (4.3.0)
A	1.20.245.10	Mainly Alpha	Up-down Bundle	Lipoxygenase-1	domain 5	CATH (4.3.0)
A	3.10.450.60	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	2.60.60.20	Mainly Beta	Sandwich	Lipoxygenase-1	PLAT/LH2 domain	CATH (4.3.0)
B	1.20.245.10	Mainly Alpha	Up-down Bundle	Lipoxygenase-1	domain 5	CATH (4.3.0)
B	3.10.450.60	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00305	Lipoxygenase (Lipoxygenase)	Lipoxygenase	-	Domain
A, B	PF01477	PLAT/LH2 domain (PLAT)	PLAT/LH2 domain	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain bind ...	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Arachidonate 15-lipoxygenase	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity arachidonate 15-lipoxygenase activity dioxygenase activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity arachidonate 15-lipoxygenase activity dioxygenase activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding linoleate 13S-lipoxygenase activity arachidonate 12(S)-lipoxygenase activity cation binding transition metal ion binding iron ion binding metal ion binding	cellular response to stimulus response to organic substance response to stimulus cellular response to interleukin-13 response to cytokine cellular response to chemical stimulus response to chemical response to interleukin-13 cellular response to cytokine stimulus cellular process cellular response to organic substance icosanoid metabolic process fatty acid metabolic process oxoacid metabolic process cellular response to stimulus response to organic substance response to stimulus cellular response to interleukin-13 response to cytokine cellular response to chemical stimulus response to chemical response to interleukin-13 cellular response to cytokine stimulus cellular process cellular response to organic substance icosanoid metabolic process fatty acid metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process organic substance metabolic process cellular lipid metabolic process small molecule metabolic process metabolic process lipoxygenase pathway monocarboxylic acid metabolic process lipid metabolic process developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion immune response regulation of adaptive immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of biological process negative regulation of adaptive immune response adaptive immune response negative regulation of immune system process immune system process regulation of immune response regulation of immune system process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process glycerophospholipid biosynthetic process phosphatidylethanolamine metabolic process phospholipid biosynthetic process phosphatidylethanolamine biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process glycerolipid metabolic process intracellular receptor signaling pathway peroxisome proliferator activated receptor signaling pathway regulation of peroxisome proliferator activated receptor signaling pathway unsaturated fatty acid metabolic process organic hydroxy compound metabolic process long-chain fatty acid biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process lipoxin biosynthetic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process lipoxin metabolic process fatty acid derivative biosynthetic process fatty acid biosynthetic process fatty acid derivative metabolic process unsaturated fatty acid biosynthetic process lipoxin A4 biosynthetic process organic hydroxy compound biosynthetic process lipoxin A4 metabolic process import into cell regulation of localization regulation of cellular component organization transport vesicle-mediated transport cellular component organization engulfment of apoptotic cell localization regulation of phagocytosis, engulfment membrane invagination phagocytosis cellular component organization or biogenesis apoptotic cell clearance plasma membrane invagination regulation of endocytosis membrane organization regulation of engulfment of apoptotic cell regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization phagocytosis, engulfment regulation of membrane invagination endocytosis cellular response to inorganic substance cellular response to metal ion response to inorganic substance response to metal ion cellular response to calcium ion response to calcium ion regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus response to stress regulation of response to stress inflammatory response positive regulation of organelle organization regulation of cytoskeleton organization positive regulation of cellular component organization regulation of actin filament-based process regulation of cellular component size cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of protein polymerization protein-containing complex assembly actin filament-based process regulation of actin filament polymerization regulation of biological quality protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization actin cytoskeleton organization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization actin filament organization regulation of actin polymerization or depolymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization positive regulation of actin filament polymerization cytoskeleton organization regulation of anatomical structure size wound healing response to wounding arachidonic acid metabolic process olefinic compound metabolic process lipid modification fatty acid oxidation lipid oxidation hepoxilin biosynthetic process hepoxilin metabolic process linoleic acid metabolic process cellular response to stress response to endoplasmic reticulum stress	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane lipid droplet intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane lipid droplet intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR020834	Lipoxygenase, conserved site	Conserved Site
A, B	IPR001024	PLAT/LH2 domain	Domain
A, B	IPR001885	Lipoxygenase, mammalian	Family
A, B	IPR042062	Lipoxygenase, vertebrates, PLAT domain	Domain
A, B	IPR036392	PLAT/LH2 domain superfamily	Homologous Superfamily
A, B	IPR036226	Lipoxigenase, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR000907	Lipoxygenase	Family
A, B	IPR020833	Lipoxygenase, iron binding site	Binding Site
A, B	IPR013819	Lipoxygenase, C-terminal	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Monotopic/peripheral	All alpha monotopic/peripheral	Lipoxygenase	Lipoxygenases

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.