2OUT

Solution Structure of HI1506, a Novel Two Domain Protein from Haemophilus influenzae

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2outa1	All alpha proteins	LEM/SAP HeH motif	Rho N-terminal domain-like	YqbF C-terminal domain-like	Uncharacterized protein HI1507 in Mu-like prophage FluMu region	(Haemophilus influenzae ) [TaxId: 727 ],	SCOPe (2.08)
A	d2outa2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	YqbF N-terminal domain-like	Mu-like prophage FluMu protein gp35, HI1506	(Haemophilus influenzae ) [TaxId: 727 ],	SCOPe (2.08)
A	d2outa3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Haemophilus influenzae ) [TaxId: 727 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	YqbF N-terminal domain-like	8022805	4001702	SCOP2 (2022-06-29)
A	SCOP2 Family	YqbF C-terminal domain-like	8022801	4001171	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PriA/YqbF domain	8035185	3000274	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Rho N-terminal domain-like	8035181	3001774	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HeH	e2outA1	A: alpha arrays	X: LEM/SAP HeH motif-like	H: LEM/SAP HeH motif	T: LEM/SAP HeH motif	F: HeH	ECOD (1.6)
A	EUF08432	e2outA2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: EUF08432	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.5.80	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)
A	1.10.720.30	Mainly Alpha	Orthogonal Bundle	Transcription Termination Factor Rho, Rna-binding Domain	Chain A, Domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17891	Mu-like prophage FluMu N-terminal domain (FluMu_N)	Mu-like prophage FluMu N-terminal domain	Structural analysis of HI1506 (also known as Mu-like prophage FluMu protein gp35) from Haemophilus influenzae show that HI1506 consists of two structured domains connected by an unstructured 30 amino acid loop. This entry is the N-terminal domain whi ...	Structural analysis of HI1506 (also known as Mu-like prophage FluMu protein gp35) from Haemophilus influenzae show that HI1506 consists of two structured domains connected by an unstructured 30 amino acid loop. This entry is the N-terminal domain which comprises a three-stranded antiparallel beta-sheet packed against an alpha-helix [1].	Domain
A	PF12949	HeH/LEM domain (HeH)	HeH/LEM domain	This is a HeH domain. HeH domains form helix-extended loop-helix (HeH) structures. It was demonstrated that the DNA-binding activity of the HEH/LEM domain assists the association of proteins with the centromeric region [1]. This domain is closely rel ...	This is a HeH domain. HeH domains form helix-extended loop-helix (HeH) structures. It was demonstrated that the DNA-binding activity of the HEH/LEM domain assists the association of proteins with the centromeric region [1]. This domain is closely related to Pfam:PF03020 and Pfam:PF02037.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mu-like prophage FluMu protein gp35, Protein HI1507 in Mu-like prophage FluMu region	DNA binding binding organic cyclic compound binding nucleic acid binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036361	SAP domain superfamily	Homologous Superfamily
A	IPR025856	HeH/LEM domain	Domain
A	IPR036269	Rho termination factor, N-terminal domain superfamily	Homologous Superfamily
A	IPR041227	Mu-like prophage FluMu N-terminal domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.