2OT8

Karyopherin Beta2/Transportin-hnRNPM NLS Complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13513	e2ot8A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13513	ECOD (1.6)
B	PF13513	e2ot8B2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13513	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat
A, B	PF13513	HEAT-like repeat (HEAT_EZ)	HEAT-like repeat	-	Repeat
A, B	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat
C, D	PF11532	HnRNP M nuclear localisation signal (HnRNP_M_NLS)	HnRNP M nuclear localisation signal	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transportin-1	small GTPase binding protein binding binding enzyme binding GTPase binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity RNA binding organic cyclic compound binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding	protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus cellular process intracellular protein transport	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle
C, D	Heterogeneous nuclear ribonucleoprotein M	protein binding binding protein domain specific binding RNA binding organic cyclic compound binding nucleic acid binding mRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing alternative mRNA splicing, via spliceosome	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nucleolus membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nucleolus intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex nuclear body nucleoplasm paraspeckles extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR040122	Importin beta family	Family
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR001494	Importin-beta, N-terminal domain	Domain
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR000357	HEAT repeat	Repeat
C, D	IPR000504	RNA recognition motif domain	Domain
C, D	IPR024666	HnRNP M, nuclear localisation signal	Domain
C, D	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
C, D	IPR034990	hnRNPM, RNA recognition motif 3	Domain
C, D	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q92973	malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acne pilocytic astrocytoma atopic eczema psoriasis chronic obstructive pulmonary disease subependymal giant cell astrocytoma esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acne pilocytic astrocytoma atopic eczema psoriasis chronic obstructive pulmonary disease subependymal giant cell astrocytoma esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Alzheimer disease plasma cell myeloma atrial fibrillation rheumatoid arthritis tuberculosis Crohn disease exocrine pancreatic carcinoma invasive ductal breast carcinoma lung cancer malignant glioma myopathy osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease astrocytic tumor primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Sjogren syndrome ulcerative colitis dermatomyositis glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma
C, D	Pharos: P52272	acute myeloid leukemia dermatomyositis large cell medulloblastoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis astrocytic tumor diabetes mellitus lymphoplasmacytic lymphoma metabolic syndrome X ovarian cancer plasma cell myeloma subependymal giant cell astrocytoma congestive heart failure acute myeloid leukemia dermatomyositis large cell medulloblastoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis astrocytic tumor diabetes mellitus lymphoplasmacytic lymphoma metabolic syndrome X ovarian cancer plasma cell myeloma subependymal giant cell astrocytoma congestive heart failure heart disease malignant pancreatic neoplasm myopathy pancreatic ductal adenocarcinoma primary cutaneous T-cell non-Hodgkin lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.