2OS8

Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	EF-hand	8062899	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Myosin_N	e2os8A1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Myosin_N	ECOD (1.6)
A	KOG0161_1st	e2os8A3	A: alpha bundles	X: Myosin VI lever arm (From Topology)	H: Myosin VI lever arm (From Topology)	T: Myosin VI lever arm	F: KOG0161_1st	ECOD (1.6)
A	Myosin_head	e2os8A2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Myosin_head	ECOD (1.6)
B	EF-hand_7_8	e2os8B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
B	EF-hand_7_4	e2os8B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_4	ECOD (1.6)
C	EF-hand_7_8	e2os8C4	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
C	EF-hand_7_4	e2os8C3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)	-	Domain
B	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain
C	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Myosin heavy chain	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding cytoskeletal motor activity	-	intracellular anatomical structure cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle protein-containing complex cytoskeleton intracellular anatomical structure cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle protein-containing complex cytoskeleton actin cytoskeleton myosin complex
B	Myosin regulatory light chain	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	-
C	Myosin essential light chain	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	intracellular organelle protein-containing complex intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle myosin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A	IPR001609	Myosin head, motor domain	Domain
A	IPR002928	Myosin tail	Domain
A	IPR004009	Myosin, N-terminal, SH3-like	Domain
A	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B	IPR002048	EF-hand domain	Domain
B	IPR011992	EF-hand domain pair	Homologous Superfamily
C	IPR002048	EF-hand domain	Domain
C	IPR011992	EF-hand domain pair	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.