2OQ2

Crystal structure of yeast PAPS reductase with PAP, a product complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Adenine nucleotide alpha hydrolases-like	8098550	3001593	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Adenine nucleotide alpha hydrolases-like	8098550	3001593	SCOP2B (2022-06-29)
C	SCOP2 Family	PAPS reductase-like	8098549	4003838	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Adenine nucleotide alpha hydrolases-like	8098550	3001593	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Adenine nucleotide alpha hydrolases-like	8098550	3001593	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01507	e2oq2A1	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF01507	ECOD (1.6)
B	PF01507	e2oq2B1	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF01507	ECOD (1.6)
C	PF01507	e2oq2C1	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF01507	ECOD (1.6)
D	PF01507	e2oq2D1	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF01507	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
B	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
C	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
D	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01507	Phosphoadenosine phosphosulfate reductase family (PAPS_reduct)	Phosphoadenosine phosphosulfate reductase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Phosphoadenosine phosphosulfate reductase	oxidoreductase activity 3'-phosphoadenylylselenate reductase activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on a sulfur group of donors oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor phosphoadenylyl-sulfate reductase (thioredoxin) activity	glutathione metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process amide biosynthetic process cellular modified amino acid metabolic process sulfur compound biosynthetic process organic substance metabolic process biosynthetic process peptide biosynthetic process cellular modified amino acid biosynthetic process glutathione biosynthetic process organic substance biosynthetic process glutathione metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process amide biosynthetic process cellular modified amino acid metabolic process sulfur compound biosynthetic process organic substance metabolic process biosynthetic process peptide biosynthetic process cellular modified amino acid biosynthetic process glutathione biosynthetic process organic substance biosynthetic process metabolic process sulfur compound metabolic process cellular process amide metabolic process nonribosomal peptide biosynthetic process peptide metabolic process oxoacid metabolic process sulfur amino acid metabolic process aspartate family amino acid biosynthetic process aspartate family amino acid metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process methionine biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process L-amino acid biosynthetic process primary metabolic process methionine metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process proteinogenic amino acid biosynthetic process sulfur amino acid biosynthetic process alpha-amino acid biosynthetic process hydrogen sulfide biosynthetic process hydrogen sulfide metabolic process serine family amino acid metabolic process cysteine biosynthetic process cysteine metabolic process serine family amino acid biosynthetic process sulfate assimilation sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004511	Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase	Family
A, B, C, D	IPR002500	Phosphoadenosine phosphosulphate reductase	Domain
A, B, C, D	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
A, B, C, D	IPR011800	Phosphoadenosine phosphosulphate reductase CysH	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.