Annotations: 2OK5

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ok5a1	Alpha and beta proteins (a/b)	vWA-like	vWA-like	Integrin A (or I) domain	Complement factor B domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2ok5a2	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	Complement factor B	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2ok5a5	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Sushi/CCP/SCR domain	8031122	4003458	SCOP2 (2022-06-29)
A	SCOP2 Family	Sushi/CCP/SCR domain	8031124	4003458	SCOP2 (2022-06-29)
A	SCOP2 Family	Sushi/CCP/SCR domain	8031127	4003458	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Sushi/CCP/SCR domain	8043500	3000902	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Sushi/CCP/SCR domain	8043502	3000902	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Sushi/CCP/SCR domain	8043505	3000902	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	vWA-like	8042312	3000832	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8042311	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trypsin_1	e2ok5A9	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
A	VWA	e2ok5A8	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)
A	Sushi	e2ok5A2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
A	Sushi_3	e2ok5A3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)
A	Sushi_1	e2ok5A1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.120	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00092	von Willebrand factor type A domain (VWA)	von Willebrand factor type A domain	-	Domain
A	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)	-	Domain
A	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Complement factor B	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding complement binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus humoral immune response positive regulation of biological process complement activation, alternative pathway positive regulation of response to stimulus complement activation positive regulation of immune response response to stress biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus humoral immune response positive regulation of biological process complement activation, alternative pathway positive regulation of response to stimulus complement activation positive regulation of immune response response to stress innate immune response regulation of immune system process positive regulation of immune system process regulation of biological process immune response defense response biological regulation defense response to symbiont immune effector process regulation of response to stimulus immune system process defense response to other organism regulation of immune response activation of immune response organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region extracellular space cellular anatomical entity blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane extracellular region extracellular space cellular anatomical entity blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane protein-containing complex catalytic complex classical-complement-pathway C3/C5 convertase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011360	Complement B/C2	Family
A	IPR028341	Complement factor B	Family
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR002035	von Willebrand factor, type A	Domain
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P00751	age-related macular degeneration complement factor b deficiency atypical hemolytic-uremic syndrome myasthenia gravis atypical hemolytic-uremic syndrome with B factor anomaly systemic lupus erythematosus ulcerative colitis hemolytic-uremic syndrome Libman-Sacks Disease macular degeneration membranous glomerulonephritis ovarian cancer age related macular degeneration 14 retinal degeneration wet macular degeneration age-related macular degeneration complement factor b deficiency atypical hemolytic-uremic syndrome myasthenia gravis atypical hemolytic-uremic syndrome with B factor anomaly systemic lupus erythematosus ulcerative colitis hemolytic-uremic syndrome Libman-Sacks Disease macular degeneration membranous glomerulonephritis ovarian cancer age related macular degeneration 14 retinal degeneration wet macular degeneration cervical cancer Hashimoto thyroiditis hypertensive disorder lung carcinoma neuromyelitis optica psoriasis skin basal cell carcinoma autism spectrum disorder brain injury heart disease non-alcoholic fatty liver disease psoriatic arthritis squamous cell lung carcinoma vitiligo endometriosis hemolytic anemia hepatitis B virus infection

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.