Annotations: 2OJW

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03951	e2ojwA3	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: PF03951	ECOD (1.6)
A	PF00120	e2ojwA4	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: PF00120	ECOD (1.6)
B	PF03951	e2ojwB2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: PF03951	ECOD (1.6)
B	PF00120	e2ojwB1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: PF00120	ECOD (1.6)
C	PF03951	e2ojwC2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: PF03951	ECOD (1.6)
C	PF00120	e2ojwC1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: PF00120	ECOD (1.6)
D	PF03951	e2ojwD2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: PF03951	ECOD (1.6)
D	PF00120	e2ojwD1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: PF00120	ECOD (1.6)
E	PF03951	e2ojwE2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: PF03951	ECOD (1.6)
E	PF00120	e2ojwE1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: PF00120	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
A	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
B	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
B	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
C	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
C	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
D	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
D	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
E	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
E	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00120	Glutamine synthetase, catalytic domain (Gln-synt_C)	Glutamine synthetase, catalytic domain	-	Domain
A, B, C, D, E	PF03951	Glutamine synthetase, beta-Grasp domain (Gln-synt_N)	Glutamine synthetase, beta-Grasp domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Glutamine synthetase	acid-ammonia (or amide) ligase activity ammonia ligase activity glutamine synthetase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding acid-ammonia (or amide) ligase activity ammonia ligase activity glutamine synthetase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity protein-cysteine S-palmitoyltransferase activity S-acyltransferase activity palmitoyltransferase activity cation binding metal ion binding identical protein binding protein binding	developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular process cellular component organization or biogenesis regulation of biological process regulation of cell motility regulation of cellular process endothelial cell migration biological regulation epithelium migration tissue migration regulation of locomotion ameboidal-type cell migration regulation of cell migration regulation of endothelial cell migration cell migration regulation of multicellular organismal process epithelial cell migration cell motility regulation of epithelial cell migration locomotion cell population proliferation regulation of sprouting angiogenesis regulation of developmental process regulation of vasculature development regulation of anatomical structure morphogenesis regulation of multicellular organismal development sprouting angiogenesis regulation of angiogenesis protein localization regulation of localization cellular localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus localization protein localization to nucleolus regulation of cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization regulation of protein localization to nucleolus glutamine family amino acid biosynthetic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process glutamine metabolic process organonitrogen compound metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process metabolic process glutamine biosynthetic process alpha-amino acid biosynthetic process response to hexose response to organic substance response to monosaccharide response to carbohydrate response to stimulus response to glucose response to chemical response to oxygen-containing compound cellular response to stimulus cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to starvation lipoprotein biosynthetic process lipoprotein metabolic process macromolecule biosynthetic process protein acylation protein lipidation protein palmitoylation macromolecule modification protein metabolic process macromolecule metabolic process protein modification process catabolic process glutamine family amino acid catabolic process dicarboxylic acid catabolic process organic acid catabolic process cellular catabolic process carboxylic acid catabolic process glutamate metabolic process amino acid catabolic process organonitrogen compound catabolic process glutamate catabolic process dicarboxylic acid metabolic process L-amino acid catabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process small molecule catabolic process organic substance catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol cell periphery plasma membrane membrane glial cell projection cell projection plasma membrane bounded cell projection cell body nucleus endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR027303	Glutamine synthetase, glycine-rich site	Conserved Site
A, B, C, D, E	IPR008146	Glutamine synthetase, catalytic domain	Domain
A, B, C, D, E	IPR027302	Glutamine synthetase, N-terminal conserved site	Conserved Site
A, B, C, D, E	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain	Homologous Superfamily
A, B, C, D, E	IPR008147	Glutamine synthetase, N-terminal domain	Domain
A, B, C, D, E	IPR036651	Glutamine synthetase, N-terminal domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: P15104	congenital brain dysgenesis due to glutamine synthetase deficiency hepatic encephalopathy Brain Diseases, Metabolic, Inborn Crohn disease hepatic coma psoriasis ulcerative colitis obesity disorder bacterial conjunctivitis primary cutaneous T-cell lymphoma tenosynovitis juvenile idiopathic arthritis exanthem lung adenocarcinoma bursitis congenital brain dysgenesis due to glutamine synthetase deficiency hepatic encephalopathy Brain Diseases, Metabolic, Inborn Crohn disease hepatic coma psoriasis ulcerative colitis obesity disorder bacterial conjunctivitis primary cutaneous T-cell lymphoma tenosynovitis juvenile idiopathic arthritis exanthem lung adenocarcinoma bursitis psoriatic arthritis eye disease uveitis malignant glioma chronic beryllium disease pulmonary fibrosis gastric cancer contact dermatitis rheumatoid arthritis glioblastoma acquired thrombocytopenia multiple sclerosis adrenal cortex carcinoma nephrotic syndrome dacryocystitis hepatocellular carcinoma dermatomyositis Sjogren syndrome angioedema asthma pemphigus atopic eczema plasma cell myeloma eosinophilic pneumonia inflammatory bowel disease autoimmune hemolytic anemia erythema multiforme temporal arteritis iridocyclitis primitive neuroectodermal tumor esophageal adenocarcinoma thyroiditis keratitis lung carcinoma medulloblastoma congenital adrenal hyperplasia gastric carcinoma miliary tuberculosis rosacea gout acute lymphoblastic leukemia musculoskeletal system disease cutaneous lupus erythematosus schizophrenia adrenocortical insufficiency depressive disorder allergic bronchopulmonary aspergillosis ankylosing spondylitis osteosarcoma skin disease astrocytic tumor pilocytic astrocytoma Down syndrome sympathetic ophthalmia idiopathic acute eosinophilic pneumonia atypical teratoid rhabdoid tumor pneumocystosis epicondylitis inherited aplastic anemia autoimmune thrombocytopenic purpura tendinitis iritis blepharoconjunctivitis large cell medulloblastoma breast cancer extrinsic allergic alveolitis malignant ependymoma pulmonary eosinophilia rheumatic heart disease Gaucher disease corneal ulcer sarcoidosis granuloma annulare Addison disease mycosis fungoides seborrheic dermatitis alcohol withdrawal dermatitis herpetiformis sinusitis allergic rhinitis aspiration pneumonitis ovarian cancer Diamond-Blackfan anemia Stevens-Johnson syndrome Hodgkins lymphoma atopic conjunctivitis synovitis autoimmune disease polymyalgia rheumatica systemic lupus erythematosus intellectual disability

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.