2O97

Crystal Structure of E. coli HU heterodimer

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2o97a_	All alpha proteins	IHF-like DNA-binding proteins	IHF-like DNA-binding proteins	Prokaryotic DNA-bending protein	HU protein	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2o97b1	All alpha proteins	IHF-like DNA-binding proteins	IHF-like DNA-binding proteins	Prokaryotic DNA-bending protein	HU protein	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Prokaryotic DNA-bending protein	8020907	4001007	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	IHF-like DNA-binding proteins	8033287	3000426	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bac_DNA_binding	e2o97A2	A: alpha arrays	X: HTH	H: IHF-like DNA-binding proteins (From Topology)	T: IHF-like DNA-binding proteins	F: Bac_DNA_binding	ECOD (1.6)
B	Bac_DNA_binding	e2o97B1	A: alpha arrays	X: HTH	H: IHF-like DNA-binding proteins (From Topology)	T: IHF-like DNA-binding proteins	F: Bac_DNA_binding	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.520.10	Few Secondary Structures	Irregular	HU Protein	Chain A	CATH (4.3.0)
B	4.10.520.10	Few Secondary Structures	Irregular	HU Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00216	Bacterial DNA-binding protein (Bac_DNA_binding)	Bacterial DNA-binding protein	-	Domain
B	PF00216	Bacterial DNA-binding protein (Bac_DNA_binding)	Bacterial DNA-binding protein	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA-binding protein HU-alpha	DNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of chromatin identical protein binding protein binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process DNA repair cellular component organization organelle organization bacterial nucleoid packaging chromosome organization cellular component organization or biogenesis chromosome condensation cellular biosynthetic process cellular metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process	membrane cellular anatomical entity primosome complex protein-containing complex intracellular anatomical structure protein-DNA complex chromosome intracellular organelle DnaA-HU complex organelle intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle membrane cellular anatomical entity primosome complex protein-containing complex intracellular anatomical structure protein-DNA complex chromosome intracellular organelle DnaA-HU complex organelle intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle cytoplasm cytosol bacterial nucleoid nucleoid HU-DNA complex DNA bending complex
B	DNA-binding protein HU-beta	DNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of chromatin identical protein binding protein binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress cellular process DNA repair cellular component organization organelle organization bacterial nucleoid packaging chromosome organization cellular component organization or biogenesis chromosome condensation cellular biosynthetic process cellular metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process	primosome complex protein-containing complex intracellular anatomical structure protein-DNA complex chromosome cellular anatomical entity intracellular organelle DnaA-HU complex organelle intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle cytoplasm primosome complex protein-containing complex intracellular anatomical structure protein-DNA complex chromosome cellular anatomical entity intracellular organelle DnaA-HU complex organelle intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle cytoplasm cytosol bacterial nucleoid nucleoid HU-DNA complex DNA bending complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010992	Integration host factor (IHF)-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR020816	Histone-like DNA-binding protein, conserved site	Conserved Site
A	IPR000119	Histone-like DNA-binding protein	Family
B	IPR010992	Integration host factor (IHF)-like DNA-binding domain superfamily	Homologous Superfamily
B	IPR020816	Histone-like DNA-binding protein, conserved site	Conserved Site
B	IPR000119	Histone-like DNA-binding protein	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.