2O93

Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth L]	d2o93l1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	T-cell transcription factor NFAT1 (NFATC2)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth L]	d2o93l2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	Rel/Dorsal transcription factors, DNA-binding domain	T-cell transcription factor NFAT1 (NFATC), DNA-binding domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth M]	d2o93m1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	T-cell transcription factor NFAT1 (NFATC2)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth M]	d2o93m2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	Rel/Dorsal transcription factors, DNA-binding domain	T-cell transcription factor NFAT1 (NFATC), DNA-binding domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth M]	d2o93m3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth O]	d2o93o1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	T-cell transcription factor NFAT1 (NFATC2)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth O]	d2o93o2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	Rel/Dorsal transcription factors, DNA-binding domain	T-cell transcription factor NFAT1 (NFATC), DNA-binding domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth L]	SCOP2B Superfamily	p53-like transcription factors	8038345	3000758	SCOP2B (2022-06-29)
C [auth L]	SCOP2B Superfamily	E set domains	8054859	3000070	SCOP2B (2022-06-29)
D [auth M]	SCOP2B Superfamily	p53-like transcription factors	8038345	3000758	SCOP2B (2022-06-29)
D [auth M]	SCOP2B Superfamily	E set domains	8054859	3000070	SCOP2B (2022-06-29)
E [auth O]	SCOP2B Superfamily	p53-like transcription factors	8038345	3000758	SCOP2B (2022-06-29)
E [auth O]	SCOP2B Superfamily	E set domains	8054859	3000070	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth L]	PF16179	e2o93L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF16179	ECOD (1.6)
C [auth L]	PF00554	e2o93L2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00554	ECOD (1.6)
D [auth M]	PF16179	e2o93M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF16179	ECOD (1.6)
D [auth M]	PF00554	e2o93M2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00554	ECOD (1.6)
E [auth O]	PF16179	e2o93O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF16179	ECOD (1.6)
E [auth O]	PF00554	e2o93O2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00554	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth L]	2.60.40.340	Mainly Beta	Sandwich	Immunoglobulin-like	Rel homology domain (RHD), DNA-binding domain	CATH (4.3.0)
C [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth M]	2.60.40.340	Mainly Beta	Sandwich	Immunoglobulin-like	Rel homology domain (RHD), DNA-binding domain	CATH (4.3.0)
D [auth M]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth O]	2.60.40.340	Mainly Beta	Sandwich	Immunoglobulin-like	Rel homology domain (RHD), DNA-binding domain	CATH (4.3.0)
E [auth O]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth L], D [auth M], E [auth O]	PF16179	Rel homology dimerisation domain (RHD_dimer)	Rel homology dimerisation domain	The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (Pfam:PF00554) and a C-terminal dimerisation domain. This is the dimerisation domain [1].	Domain
C [auth L], D [auth M], E [auth O]	PF00554	Rel homology DNA-binding domain (RHD_DNA_bind)	Rel homology DNA-binding domain	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immu ...	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF16179) that functions as a dimerisation domain [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	kappaB enhancer element, DNA 25-mer	-	-	-
B	kappaB enhancer element, DNA 25-mer	-	-	-
C [auth L], D [auth M], E [auth O]	actor of activated T-cells, cytoplasmic 2	DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding protein binding 14-3-3 protein binding molecular adaptor activity phosphatase binding enzyme binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cellular response to stimulus cellular response to stress response to stimulus DNA damage response developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus calcineurin-NFAT signaling cascade regulation of biological process regulation of cellular process signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction calcineurin-mediated signaling immune response-regulating cell surface receptor signaling pathway positive regulation of biological process positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic cyclic compound biosynthetic process myotube cell development cellular developmental process cell development muscle cell differentiation myotube differentiation muscle structure development muscle cell development cell differentiation striated muscle cell differentiation cell migration cell motility cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to chemical stimulus response to metal ion cellular response to calcium ion response to calcium ion regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of cellular component organization regulation of cellular component organization regulation of syncytium formation by plasma membrane fusion regulation of developmental process cell-cell fusion cellular component organization positive regulation of developmental process cellular component organization or biogenesis syncytium formation positive regulation of myoblast fusion myoblast fusion regulation of myoblast fusion positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis anatomical structure formation involved in morphogenesis smooth muscle cell differentiation negative regulation of biological process regulation of smooth muscle cell differentiation negative regulation of muscle cell differentiation regulation of cell differentiation vascular associated smooth muscle cell differentiation negative regulation of cellular process negative regulation of cell differentiation negative regulation of developmental process negative regulation of vascular associated smooth muscle cell differentiation regulation of vascular associated smooth muscle cell differentiation vasculature development circulatory system development negative regulation of smooth muscle cell differentiation regulation of muscle cell differentiation regulation of transcription by RNA polymerase II positive regulation of cell population proliferation positive regulation of B cell proliferation regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation B cell activation cell activation positive regulation of lymphocyte proliferation B cell proliferation positive regulation of B cell activation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation positive regulation of multicellular organismal process regulation of lymphocyte activation	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity transcription factor AP-1 complex intracellular organelle organelle cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity transcription factor AP-1 complex intracellular organelle organelle cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth L], D [auth M], E [auth O]	IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily	Homologous Superfamily
C [auth L], D [auth M], E [auth O]	IPR002909	IPT domain	Domain
C [auth L], D [auth M], E [auth O]	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
C [auth L], D [auth M], E [auth O]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
C [auth L], D [auth M], E [auth O]	IPR011539	Rel homology domain, DNA-binding domain	Domain
C [auth L], D [auth M], E [auth O]	IPR008366	Nuclear factor of activated T cells (NFAT)	Family
C [auth L], D [auth M], E [auth O]	IPR032397	Rel homology dimerisation domain	Domain
C [auth L], D [auth M], E [auth O]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth L], D [auth M], E [auth O]	Pharos: Q13469	nervous system disorder pulmonary hypertension allergic rhinitis malignant ependymoma non-small cell lung carcinoma subependymal giant cell astrocytoma breast cancer medulloblastoma osteosarcoma type 2 diabetes mellitus interstitial cystitis ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.