Annotations: 2O8B

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	MutS N-terminal domain-like	8056705	3001688	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	MutS domain III-like	8056707	3001131	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8056708	3002020	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	MutS domain II-like	8056706	3000587	SCOP2B (2022-06-29)
D [auth B]	SCOP2 Family	MutS-like	8018583	4004015	SCOP2 (2022-06-29)
D [auth B]	SCOP2 Superfamily	MutS N-terminal domain-like	8056718	3001688	SCOP2 (2022-06-29)
D [auth B]	SCOP2 Superfamily	ABC transporter-like P-loop ATPases	8056721	3002020	SCOP2 (2022-06-29)
D [auth B]	SCOP2 Superfamily	MutS domain II-like	8056719	3000587	SCOP2 (2022-06-29)
D [auth B]	SCOP2 Superfamily	MutS domain III-like	8056720	3001131	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	MutS_III	e2o8bA2	A: alpha bundles	X: Four-helical up-and-down bundle	H: DNA repair protein MutS, domain III (From Topology)	T: DNA repair protein MutS, domain III	F: MutS_III	ECOD (1.6)
C [auth A]	MutS_I	e2o8bA3	A: a+b two layers	X: Homing endonucleases-like	H: DNA repair protein MutS, domain I (From Topology)	T: DNA repair protein MutS, domain I	F: MutS_I	ECOD (1.6)
C [auth A]	MutS_V	e2o8bA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MutS_V	ECOD (1.6)
C [auth A]	MutS_II	e2o8bA4	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: MutS_II	ECOD (1.6)
D [auth B]	MutS_III	e2o8bB3	A: alpha bundles	X: Four-helical up-and-down bundle	H: DNA repair protein MutS, domain III (From Topology)	T: DNA repair protein MutS, domain III	F: MutS_III	ECOD (1.6)
D [auth B]	MutS_I	e2o8bB2	A: a+b two layers	X: Homing endonucleases-like	H: DNA repair protein MutS, domain I (From Topology)	T: DNA repair protein MutS, domain I	F: MutS_I	ECOD (1.6)
D [auth B]	MutS_V	e2o8bB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MutS_V	ECOD (1.6)
D [auth B]	MutS_II	e2o8bB4	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: MutS_II	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.40.1170.10	Alpha Beta	3-Layer(aba) Sandwich	MutS, DNA mismatch repair protein, domain I	DNA repair protein MutS, domain I	CATH (4.3.0)
C [auth A]	3.30.420.110	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C [auth A]	1.10.1420.10	Mainly Alpha	Orthogonal Bundle	MutS, DNA mismatch repair protein	Chain A, domain 3	CATH (4.3.0)
C [auth A]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D [auth B]	3.40.1170.10	Alpha Beta	3-Layer(aba) Sandwich	MutS, DNA mismatch repair protein, domain I	DNA repair protein MutS, domain I	CATH (4.3.0)
D [auth B]	3.30.420.110	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
D [auth B]	1.10.1420.10	Mainly Alpha	Orthogonal Bundle	MutS, DNA mismatch repair protein	Chain A, domain 3	CATH (4.3.0)
D [auth B]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF01624	MutS domain I (MutS_I)	MutS domain I	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	Domain
C [auth A]	PF05188	MutS domain II (MutS_II)	MutS domain II	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. This domain corresponds to domain II in Thermus aquaticus MutS as characterised in [4], and has similarity resembles RNAse-H-like domains (see Pfam:PF00075).	Domain
C [auth A]	PF05192	MutS domain III (MutS_III)	MutS domain III	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterised in [4].	Domain
C [auth A]	PF00488	MutS domain V (MutS_V)	MutS domain V	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterised in [4], which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.	Domain
C [auth A]	PF05190	MutS family domain IV (MutS_IV)	MutS family domain IV	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds in part with globular domain IV, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	Domain
D [auth B]	PF01624	MutS domain I (MutS_I)	MutS domain I	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	Domain
D [auth B]	PF05188	MutS domain II (MutS_II)	MutS domain II	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. This domain corresponds to domain II in Thermus aquaticus MutS as characterised in [4], and has similarity resembles RNAse-H-like domains (see Pfam:PF00075).	Domain
D [auth B]	PF05192	MutS domain III (MutS_III)	MutS domain III	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterised in [4].	Domain
D [auth B]	PF00488	MutS domain V (MutS_V)	MutS domain V	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterised in [4], which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.	Domain
D [auth B]	PF05190	MutS family domain IV (MutS_IV)	MutS family domain IV	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS prot ...	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds in part with globular domain IV, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	5'-D(GPAPAPCPCPGPCPGPCPGPCPTPAPGP*G)-3'	-	-	-
B [auth F]	5'-D(CPCPTPAPGPCPGPTPGPCPGPGPTPTP*C)-3'	-	-	-
C [auth A]	DNA mismatch repair protein Msh2	DNA binding guanine/thymine mispair binding double-stranded DNA binding binding organic cyclic compound binding mismatched DNA binding nucleic acid binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA damage sensor activity small molecule sensor activity DNA binding guanine/thymine mispair binding double-stranded DNA binding binding organic cyclic compound binding mismatched DNA binding nucleic acid binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding sequence-specific DNA binding sequence-specific double-stranded DNA binding centromeric DNA binding protein-containing complex binding chromatin binding damaged DNA binding identical protein binding protein binding protein homodimerization activity protein dimerization activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stimulus regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of immune response organic substance biosynthetic process regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response immune response cellular metabolic process DNA recombination primary metabolic process DNA metabolic process immune effector process regulation of gene expression biosynthetic process positive regulation of DNA metabolic process regulation of response to stimulus B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of macromolecule biosynthetic process metabolic process regulation of DNA metabolic process immunoglobulin production regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination positive regulation of cellular metabolic process somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments positive regulation of biosynthetic process regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of cellular process production of molecular mediator of immune response positive regulation of immunoglobulin production regulation of isotype switching cell activation regulation of macromolecule metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression immune system process somatic diversification of immune receptors via germline recombination within a single locus cellular process positive regulation of cellular biosynthetic process regulation of lymphocyte activation lymphocyte mediated immunity regulation of immune effector process regulation of DNA recombination positive regulation of leukocyte mediated immunity regulation of cellular process cell activation involved in immune response nucleobase-containing compound metabolic process positive regulation of developmental process positive regulation of cell activation positive regulation of metabolic process positive regulation of leukocyte activation leukocyte mediated immunity somatic diversification of immune receptors regulation of nucleobase-containing compound metabolic process positive regulation of adaptive immune response positive regulation of immune system process somatic recombination of immunoglobulin genes involved in immune response regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of adaptive immune response regulation of cellular metabolic process regulation of B cell mediated immunity somatic diversification of immunoglobulins organic cyclic compound metabolic process regulation of leukocyte mediated immunity regulation of immune response positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response macromolecule metabolic process regulation of metabolic process isotype switching immune system development immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity cellular biosynthetic process positive regulation of biological process lymphocyte activation positive regulation of B cell mediated immunity leukocyte activation positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains organic substance metabolic process positive regulation of isotype switching to IgG isotypes regulation of multicellular organismal process lymphocyte activation involved in immune response regulation of biosynthetic process B cell activation biological regulation gene expression adaptive immune response immunoglobulin mediated immune response positive regulation of B cell activation regulation of isotype switching to IgG isotypes regulation of lymphocyte mediated immunity regulation of immunoglobulin production isotype switching to IgG isotypes response to light stimulus response to radiation response to abiotic stimulus response to UV response to UV-B cellular response to stimulus mismatch repair cellular response to stress DNA damage response response to stress DNA repair response to X-ray response to ionizing radiation negative regulation of biological process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of DNA recombination negative regulation of DNA metabolic process embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular component organization or biogenesis aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds generation of precursor metabolites and energy DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle mitotic intra-S DNA damage checkpoint signaling regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic cell cycle process signal transduction in response to DNA damage cellular developmental process hemopoiesis cell development mononuclear cell differentiation lymphocyte differentiation B cell differentiation cell differentiation leukocyte differentiation sexual reproduction multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism gamete generation germ cell development protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization somatic diversification of immune receptors via somatic mutation somatic hypermutation of immunoglobulin genes neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process postreplication repair mitotic recombination determination of adult lifespan signal transduction by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway regulation of helicase activity positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of helicase activity regulation of catalytic activity positive regulation of ATP-dependent activity positive regulation of catalytic activity double-strand break repair positive regulation of isotype switching to IgA isotypes isotype switching to IgA isotypes regulation of isotype switching to IgA isotypes	membrane cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex membrane cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle MutSbeta complex mismatch repair complex MutSalpha complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
D [auth B]	DNA mismatch repair protein MSH6	DNA binding guanine/thymine mispair binding double-stranded DNA binding binding organic cyclic compound binding mismatched DNA binding nucleic acid binding protein-containing complex binding chromatin binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA binding guanine/thymine mispair binding double-stranded DNA binding binding organic cyclic compound binding mismatched DNA binding nucleic acid binding protein-containing complex binding chromatin binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity damaged DNA binding DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding methylated histone binding protein binding modification-dependent protein binding histone binding methylation-dependent protein binding enzyme binding	immune system development multicellular organismal process immunoglobulin production cellular biosynthetic process somatic cell DNA recombination nucleobase-containing compound metabolic process multicellular organism development somatic recombination of immunoglobulin gene segments organic substance metabolic process anatomical structure development organic substance biosynthetic process somatic diversification of immune receptors system development developmental process immune system development multicellular organismal process immunoglobulin production cellular biosynthetic process somatic cell DNA recombination nucleobase-containing compound metabolic process multicellular organism development somatic recombination of immunoglobulin gene segments organic substance metabolic process anatomical structure development organic substance biosynthetic process somatic diversification of immune receptors system development developmental process production of molecular mediator of immune response DNA recombination cellular metabolic process primary metabolic process DNA metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process somatic diversification of immunoglobulins organic cyclic compound metabolic process biosynthetic process immune system process somatic diversification of immune receptors via germline recombination within a single locus metabolic process cellular process macromolecule metabolic process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell death intracellular signal transduction cell communication apoptotic signaling pathway signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death mismatch repair meiotic cell cycle process meiotic mismatch repair cellular response to stress response to stress cell cycle cell cycle process DNA repair meiotic cell cycle meiosis I cell cycle process DNA damage response regulation of DNA recombination negative regulation of biological process regulation of primary metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process regulation of macromolecule metabolic process negative regulation of DNA recombination negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process somatic diversification of immune receptors via somatic mutation somatic hypermutation of immunoglobulin genes determination of adult lifespan intrinsic apoptotic signaling pathway in response to DNA damage response to light stimulus response to radiation response to abiotic stimulus response to UV regulation of helicase activity positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of helicase activity regulation of catalytic activity positive regulation of ATP-dependent activity positive regulation of catalytic activity adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity B cell activation involved in immune response cell activation involved in immune response leukocyte mediated immunity somatic recombination of immunoglobulin genes involved in immune response immune response immune effector process B cell mediated immunity isotype switching immunoglobulin production involved in immunoglobulin-mediated immune response lymphocyte activation leukocyte activation somatic diversification of immunoglobulins involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response B cell activation cell activation immunoglobulin mediated immune response adaptive immune response	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle MutSalpha complex mismatch repair complex cytoplasm cytosol membrane-enclosed lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle MutSalpha complex mismatch repair complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle Golgi apparatus endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR007861	DNA mismatch repair protein MutS, clamp	Domain
C [auth A]	IPR016151	DNA mismatch repair protein MutS, N-terminal	Homologous Superfamily
C [auth A]	IPR011184	DNA mismatch repair Msh2-type	Family
C [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C [auth A]	IPR000432	DNA mismatch repair protein MutS, C-terminal	Domain
C [auth A]	IPR007696	DNA mismatch repair protein MutS, core	Domain
C [auth A]	IPR032642	DNA mismatch repair protein Msh2, ATP-binding cassette domain	Domain
C [auth A]	IPR036187	DNA mismatch repair protein MutS, core domain superfamily	Homologous Superfamily
C [auth A]	IPR045076	DNA mismatch repair MutS family	Family
C [auth A]	IPR007860	DNA mismatch repair protein MutS, connector domain	Domain
C [auth A]	IPR007695	DNA mismatch repair protein MutS-like, N-terminal	Domain
C [auth A]	IPR036678	MutS, connector domain superfamily	Homologous Superfamily
D [auth B]	IPR045076	DNA mismatch repair MutS family	Family
D [auth B]	IPR000313	PWWP domain	Domain
D [auth B]	IPR007861	DNA mismatch repair protein MutS, clamp	Domain
D [auth B]	IPR017261	DNA mismatch repair protein MutS/MSH	Family
D [auth B]	IPR016151	DNA mismatch repair protein MutS, N-terminal	Homologous Superfamily
D [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth B]	IPR000432	DNA mismatch repair protein MutS, C-terminal	Domain
D [auth B]	IPR007696	DNA mismatch repair protein MutS, core	Domain
D [auth B]	IPR007860	DNA mismatch repair protein MutS, connector domain	Domain
D [auth B]	IPR007695	DNA mismatch repair protein MutS-like, N-terminal	Domain
D [auth B]	IPR036187	DNA mismatch repair protein MutS, core domain superfamily	Homologous Superfamily
D [auth B]	IPR036678	MutS, connector domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A]	Pharos: P43246	Lynch syndrome Muir-Torre syndrome ovarian cancer cancer colorectal cancer Lynch syndrome 1 mismatch repair cancer syndrome mismatch repair cancer syndrome 1 neurofibromatosis type 1 hematopoietic and lymphoid system neoplasm Hereditary non-polyposis colorectal cancer syndrome large cell medulloblastoma acute myeloid leukemia malignant glioma medulloblastoma Lynch syndrome Muir-Torre syndrome ovarian cancer cancer colorectal cancer Lynch syndrome 1 mismatch repair cancer syndrome mismatch repair cancer syndrome 1 neurofibromatosis type 1 hematopoietic and lymphoid system neoplasm Hereditary non-polyposis colorectal cancer syndrome large cell medulloblastoma acute myeloid leukemia malignant glioma medulloblastoma neurofibromatosis endometrial cancer endometrium carcinoma in situ pituitary cancer glioma hereditary breast carcinoma lung adenocarcinoma atypical teratoid rhabdoid tumor malignant mesothelioma colon carcinoma diabetes mellitus nasopharyngeal carcinoma endometrial carcinoma ovarian carcinoma familial prostate carcinoma uterine disease glioma susceptibility 1 lung cancer breast cancer colorectal adenocarcinoma colorectal carcinoma digestive system disease non-small cell lung carcinoma endometriosis ovarian neoplasm
D [auth B]	Pharos: P52701	Lynch syndrome colorectal cancer, hereditary nonpolyposis, type 5 mismatch repair cancer syndrome endometrial cancer mismatch repair cancer syndrome 1 lung adenocarcinoma Muir-Torre syndrome ovarian cancer cancer colorectal cancer Microsatellite Instability endometrial carcinoma glioblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma Lynch syndrome colorectal cancer, hereditary nonpolyposis, type 5 mismatch repair cancer syndrome endometrial cancer mismatch repair cancer syndrome 1 lung adenocarcinoma Muir-Torre syndrome ovarian cancer cancer colorectal cancer Microsatellite Instability endometrial carcinoma glioblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma IgA glomerulonephritis large cell medulloblastoma lung cancer BAP1-related tumor predisposition syndrome Lynch syndrome 1 colon carcinoma Down syndrome nasopharyngeal carcinoma familial prostate carcinoma non-small cell lung carcinoma hematopoietic and lymphoid system neoplasm ovarian carcinoma peripheral nervous system disease primitive neuroectodermal tumor invasive ductal breast carcinoma subependymal giant cell astrocytoma leukemia attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma breast-ovarian cancer, familial, susceptibility to, 1 malignant ependymoma colorectal adenocarcinoma dermatomyositis medulloblastoma endometriosis osteosarcoma hereditary breast carcinoma ovarian neoplasm peripheral neuropathy psoriasis juvenile dermatomyositis uterine disease atypical teratoid rhabdoid tumor malignant glioma digestive system disease endometrium carcinoma in situ neurofibromatosis type 1