2O74

Structure of OHCU decarboxylase in complex with guanine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2o74a_	All alpha proteins	UraD-like	UraD-Like	UraD-like	OHCU decarboxylase, UraD	zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
B	d2o74b_	All alpha proteins	UraD-like	UraD-Like	UraD-like	OHCU decarboxylase, UraD	zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
C	d2o74c_	All alpha proteins	UraD-like	UraD-Like	UraD-like	OHCU decarboxylase, UraD	zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
D	d2o74d_	All alpha proteins	UraD-like	UraD-Like	UraD-like	OHCU decarboxylase, UraD	zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
E	d2o74e_	All alpha proteins	UraD-like	UraD-Like	UraD-like	OHCU decarboxylase, UraD	zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)
F	d2o74f_	All alpha proteins	UraD-like	UraD-Like	UraD-like	OHCU decarboxylase, UraD	zebrafish (Danio rerio ) [TaxId: 7955 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	UraD-Like	8035027	3001795	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	UraD-Like	8035027	3001795	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	UraD-Like	8035027	3001795	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	UraD-Like	8035027	3001795	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	UraD-Like	8035027	3001795	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	UraD-Like	8035027	3001795	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF09349	e2o74A1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
B	PF09349	e2o74B1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
C	PF09349	e2o74C1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
D	PF09349	e2o74D1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
E	PF09349	e2o74E1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)
F	PF09349	e2o74F1	A: alpha arrays	X: UraD-like (From Topology)	H: UraD-like (From Topology)	T: UraD-like	F: PF09349	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (4.3.0)
B	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (4.3.0)
C	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (4.3.0)
D	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (4.3.0)
E	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (4.3.0)
F	1.10.3330.10	Mainly Alpha	Orthogonal Bundle	UraD-like	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF09349	OHCU decarboxylase (OHCU_decarbox)	OHCU decarboxylase	The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is ...	The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (Pfam:PF01014) and step two is catalysed by HIUases (Pfam:PF00576).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	OHCU decarboxylase	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	organonitrogen compound catabolic process catabolic process organonitrogen compound metabolic process purine-containing compound catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process urate metabolic process organic cyclic compound metabolic process organic substance metabolic process urate catabolic process small molecule metabolic process metabolic process small molecule catabolic process organic substance catabolic process organonitrogen compound catabolic process catabolic process organonitrogen compound metabolic process purine-containing compound catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process urate metabolic process organic cyclic compound metabolic process organic substance metabolic process urate catabolic process small molecule metabolic process metabolic process small molecule catabolic process organic substance catabolic process allantoin metabolic process amide metabolic process purine nucleobase metabolic process primary metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle peroxisome microbody cytoplasm cellular anatomical entity intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036778	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR017580	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 1	Domain
A, B, C, D, E A, B, C, D, E, F	IPR018020	Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.