2O6T

Crystal structure of the PA5185 protein from Pseudomonas Aeruginosa strain PAO1- orthorhombic form (P2221).

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2o6ta2	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	4HBT-like	Hypothetical thioesterase PA5185	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
A	d2o6ta3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
B [auth C]	d2o6tc_	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	4HBT-like	Hypothetical thioesterase PA5185	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
C [auth E]	d2o6te_	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	4HBT-like	Hypothetical thioesterase PA5185	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
D [auth G]	d2o6tg_	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	4HBT-like	Hypothetical thioesterase PA5185	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
E [auth I]	d2o6ti2	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	4HBT-like	Hypothetical thioesterase PA5185	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
E [auth I]	d2o6ti3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
F [auth K]	d2o6tk_	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	4HBT-like	Hypothetical thioesterase PA5185	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8035014	3000149	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8035014	3000149	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8035014	3000149	SCOP2B (2022-06-29)
D [auth G]	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8035014	3000149	SCOP2B (2022-06-29)
E [auth I]	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8035014	3000149	SCOP2B (2022-06-29)
F [auth K]	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8035014	3000149	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13279	e2o6tA1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF13279	ECOD (1.6)
B [auth C]	PF13279	e2o6tC1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF13279	ECOD (1.6)
C [auth E]	PF13279	e2o6tE1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF13279	ECOD (1.6)
D [auth G]	PF13279	e2o6tG1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF13279	ECOD (1.6)
E [auth I]	PF13279	e2o6tI1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF13279	ECOD (1.6)
F [auth K]	PF13279	e2o6tK1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF13279	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.129.10	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)
B [auth C]	3.10.129.10	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)
C [auth E]	3.10.129.10	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)
D [auth G]	3.10.129.10	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)
E [auth I]	3.10.129.10	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)
F [auth K]	3.10.129.10	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	PF03061	Thioesterase superfamily (4HBT)	Thioesterase superfamily	This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas ...	This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	THIOESTERASE	hydrolase activity, acting on ester bonds thiolester hydrolase activity hydrolase activity fatty acyl-CoA hydrolase activity catalytic activity acyl-CoA hydrolase activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth E], D [auth G], E [auth I], A, B [auth C], C [auth E], D [auth G], E [auth I], F [auth K]	IPR029069	HotDog domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.