2O6L

Crystal Structure of the UDP-Glucuronic Acid Binding Domain of the Human Drug Metabolizing UDP-Glucuronosyltransferase 2B7

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UDPGT	e2o6lA1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: UDPGT	ECOD (1.6)
B	UDPGT	e2o6lB1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: UDPGT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)
B	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00201	UDP-glucoronosyl and UDP-glucosyl transferase (UDPGT)	UDP-glucoronosyl and UDP-glucosyl transferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	UDP-glucuronosyltransferase 2B7	UDP-glycosyltransferase activity glycosyltransferase activity glucuronosyltransferase activity transferase activity hexosyltransferase activity catalytic activity	oxoacid metabolic process uronic acid metabolic process cellular metabolic process carboxylic acid metabolic process organic acid metabolic process cellular glucuronidation organic substance metabolic process glucuronate metabolic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process primary metabolic process lipid metabolic process oxoacid metabolic process uronic acid metabolic process cellular metabolic process carboxylic acid metabolic process organic acid metabolic process cellular glucuronidation organic substance metabolic process glucuronate metabolic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process primary metabolic process lipid metabolic process cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus xenobiotic metabolic process response to xenobiotic stimulus regulation of hormone levels steroid metabolic process biological regulation androgen metabolic process hormone metabolic process organic cyclic compound metabolic process regulation of biological quality estrogen metabolic process	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR035595	UDP-glycosyltransferase family, conserved site	Conserved Site
A, B	IPR002213	UDP-glucuronosyl/UDP-glucosyltransferase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P16662	urinary bladder cancer facioscapulohumeral muscular dystrophy ulcerative colitis peripheral nervous system disease peripheral neuropathy urinary bladder neoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.