2O61

Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth B]	d2o61b1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	p50 subunit of NF-kappa B transcription factor	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth B]	d2o61b2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	Rel/Dorsal transcription factors, DNA-binding domain	p50 subunit of NF-kappa B (NFKB), N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth B]	d2o61b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	IRF DNA-binding domain-like	8077686	4000230	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Winged helix DNA-binding domain	8077687	3000034	SCOP2 (2022-06-29)
C [auth A]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057688	3000034	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	E set domains	8054879	3000070	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	p53-like transcription factors	8040235	3000758	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	E set domains	8054865	3000070	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	p53-like transcription factors	8040226	3000758	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	PF16179	e2o61A6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF16179	ECOD (1.6)
C [auth A]	PF00554	e2o61A5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00554	ECOD (1.6)
C [auth A]	PF00605	e2o61A4	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00605	ECOD (1.6)
D [auth B]	PF16179	e2o61B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF16179	ECOD (1.6)
D [auth B]	PF00554	e2o61B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00554	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	2.60.40.340	Mainly Beta	Sandwich	Immunoglobulin-like	Rel homology domain (RHD), DNA-binding domain	CATH (4.3.0)
C [auth A]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth A]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
D [auth B]	2.60.40.340	Mainly Beta	Sandwich	Immunoglobulin-like	Rel homology domain (RHD), DNA-binding domain	CATH (4.3.0)
D [auth B]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF00605	Interferon regulatory factor transcription factor (IRF)	Interferon regulatory factor transcription factor	This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.	Domain
C [auth A]	PF16179	Rel homology dimerisation domain (RHD_dimer)	Rel homology dimerisation domain	The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (Pfam:PF00554) and a C-terminal dimerisation domain. This is the dimerisation domain [1].	Domain
C [auth A]	PF00554	Rel homology DNA-binding domain (RHD_DNA_bind)	Rel homology DNA-binding domain	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immu ...	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF16179) that functions as a dimerisation domain [1-2].	Domain
D [auth B]	PF16179	Rel homology dimerisation domain (RHD_dimer)	Rel homology dimerisation domain	The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (Pfam:PF00554) and a C-terminal dimerisation domain. This is the dimerisation domain [1].	Domain
D [auth B]	PF00554	Rel homology DNA-binding domain (RHD_DNA_bind)	Rel homology DNA-binding domain	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immu ...	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF16179) that functions as a dimerisation domain [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	36-MER	-	-	-
B [auth F]	34-MER	-	-	-
C [auth A]	Transcription factor p65/Interferon regulatory factor 7/Interferon regulatory factor 3 fusion protein	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding protein binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity protein dimerization activity histone deacetylase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor binding general transcription initiation factor binding ankyrin repeat binding ion binding anion binding phosphate ion binding small molecule binding kinase binding protein kinase binding transcription coregulator binding transcription coactivator binding chromatin DNA binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding NF-kappaB binding cytoskeletal protein binding actinin binding peptide binding	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response cellular response to stress DNA damage response apoptotic process cell death programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of cell communication response to organic substance positive regulation of signal transduction regulation of type I interferon-mediated signaling pathway response to cytokine regulation of signal transduction interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of response to cytokine stimulus response to chemical response to type I interferon positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to organic substance positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway cellular response to chemical stimulus type I interferon-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA transcription mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process organic cyclic compound metabolic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process MDA-5 signaling pathway defense response to virus response to virus multicellular organismal process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of biosynthetic process positive regulation of type I interferon production type I interferon production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process regulation of type I interferon production regulation of primary metabolic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process interferon-alpha production regulation of interferon-alpha production positive regulation of interferon-alpha production positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway toll-like receptor 4 signaling pathway response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to lipid response to molecule of bacterial origin cellular response to nitrogen compound cellular response to dsRNA cellular response to exogenous dsRNA cellular response to organic cyclic compound response to dsRNA response to nitrogen compound response to exogenous dsRNA response to organic cyclic compound toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway regulation of interferon-beta production interferon-beta production positive regulation of interferon-beta production antiviral innate immune response regulation of inflammatory response inflammatory response programmed necrotic cell death macrophage apoptotic process myeloid cell apoptotic process leukocyte apoptotic process inflammatory cell apoptotic process cellular response to virus response to xenobiotic stimulus response to tumor cell defense response to tumor cell response to ischemia cell-cell signaling postsynaptic signal transduction synaptic signaling postsynapse to nucleus signaling pathway cellular response to growth factor stimulus response to endogenous stimulus cell surface receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor signaling pathway cellular response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus response to growth factor enzyme-linked receptor protein signaling pathway organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process protein catabolic process macromolecule catabolic process protein metabolic process organic substance catabolic process positive regulation of miRNA metabolic process regulation of miRNA metabolic process miRNA metabolic process ncRNA metabolic process non-canonical NF-kappaB signal transduction positive regulation of miRNA transcription miRNA transcription regulation of miRNA transcription response to nutrient levels response to organonitrogen compound response to nutrient response to vitamin response to cobalamin positive regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production positive regulation of T cell receptor signaling pathway regulation of antigen receptor-mediated signaling pathway regulation of T cell receptor signaling pathway T cell receptor signaling pathway antigen receptor-mediated signaling pathway positive regulation of antigen receptor-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 cellular response to lipoteichoic acid response to lipoteichoic acid cellular defense response negative regulation of signaling negative regulation of biological process extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of apoptotic signaling pathway response to organophosphorus response to purine-containing compound response to cAMP negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cellular aldehyde metabolic process acetaldehyde metabolic process cellular response to interleukin-1 response to interleukin-1 protein-DNA complex organization cellular component organization protein-containing complex organization chromatin organization cellular component organization or biogenesis G protein-coupled receptor signaling pathway neuropeptide signaling pathway developmental process epithelium development epidermis development molting cycle process hair cycle animal organ development tissue development skin development skin epidermis development hair follicle development molting cycle anatomical structure development hair cycle process regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation negative regulation of miRNA transcription negative regulation of miRNA metabolic process cellular response to tumor necrosis factor response to tumor necrosis factor regulation of amide metabolic process amyloid precursor protein catabolic process positive regulation of protein metabolic process regulation of amyloid-beta formation positive regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process amyloid precursor protein metabolic process amyloid-beta formation regulation of protein metabolic process positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process cellular response to nicotine response to nicotine response to hormone response to peptide hormone response to insulin regulation of non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction interleukin-1-mediated signaling pathway regulation of developmental process angiogenesis regulation of vasculature development multicellular organism development tube morphogenesis regulation of anatomical structure morphogenesis system development blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development anatomical structure morphogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process negative regulation of post-translational protein modification regulation of protein sumoylation regulation of protein modification process peptidyl-lysine modification peptidyl-amino acid modification negative regulation of protein modification process protein modification process regulation of protein modification by small protein conjugation or removal negative regulation of protein sumoylation negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein sumoylation macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of cell adhesion regulation of cell adhesion positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte adhesion to vascular endothelial cell leukocyte cell-cell adhesion positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion leukocyte adhesion to vascular endothelial cell regulation of leukocyte cell-cell adhesion regulation of cell-cell adhesion response to ketone response to progesterone response to steroid hormone response to light stimulus response to radiation response to abiotic stimulus response to UV response to UV-B interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production insulin receptor signaling pathway regulation of cellular response to insulin stimulus cellular response to hormone stimulus regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus negative regulation of cellular response to insulin stimulus cellular response to organonitrogen compound negative regulation of insulin receptor signaling pathway cellular response to insulin stimulus nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity tumor necrosis factor-mediated signaling pathway negative regulation of protein catabolic process negative regulation of catabolic process regulation of catabolic process regulation of protein catabolic process hepaticobiliary system development gland development liver development response to acid chemical response to amino acid animal organ morphogenesis response to peptidoglycan cellular response to peptidoglycan regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of nervous system development cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process neurogenesis gliogenesis positive regulation of cell differentiation cell differentiation positive regulation of neurogenesis Schwann cell differentiation positive regulation of Schwann cell differentiation positive regulation of cell development regulation of glial cell differentiation peripheral nervous system development nervous system development positive regulation of glial cell differentiation regulation of Schwann cell differentiation glial cell differentiation cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species hormone-mediated signaling pathway prolactin signaling pathway response to muramyl dipeptide response to hepatocyte growth factor cellular response to hepatocyte growth factor stimulus negative regulation of intracellular signal transduction negative regulation of non-canonical NF-kappaB signal transduction response to angiotensin cellular response to angiotensin response to mechanical stimulus response to muscle stretch negative regulation of leukocyte apoptotic process regulation of leukocyte apoptotic process negative regulation of macrophage apoptotic process regulation of macrophage apoptotic process negative regulation of myeloid cell apoptotic process regulation of myeloid cell apoptotic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process myeloid leukocyte differentiation regulation of leukocyte differentiation mononuclear cell differentiation monocyte differentiation regulation of monocyte differentiation hemopoiesis regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation myeloid cell differentiation regulation of hemopoiesis leukocyte differentiation regulation of adaptive immune response regulation of MyD88-dependent toll-like receptor signaling pathway regulation of pattern recognition receptor signaling pathway regulation of toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway viral latency viral process establishment of viral latency regulation of MyD88-independent toll-like receptor signaling pathway	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle mitochondrion intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen transcription regulator complex NF-kappaB complex nuclear protein-containing complex synapse cell junction glutamatergic synapse NF-kappaB p50/p65 complex endosome membrane membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle organelle membrane
D [auth B]	Nuclear factor NF-kappa-B p105 subunit	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding cytoskeletal protein binding actinin binding	cellular response to nitrogen compound cellular response to stimulus response to organic substance cellular response to dsRNA response to stimulus cellular response to organic cyclic compound response to dsRNA response to nitrogen compound cellular response to chemical stimulus response to chemical cellular process cellular response to organic substance response to organic cyclic compound cellular response to interleukin-17 cellular response to nitrogen compound cellular response to stimulus response to organic substance cellular response to dsRNA response to stimulus cellular response to organic cyclic compound response to dsRNA response to nitrogen compound cellular response to chemical stimulus response to chemical cellular process cellular response to organic substance response to organic cyclic compound cellular response to interleukin-17 response to interleukin-17 response to cytokine cellular response to cytokine stimulus developmental process multicellular organismal process mammary gland morphogenesis mammary gland development gland development animal organ development anatomical structure morphogenesis gland morphogenesis tissue remodeling anatomical structure development mammary gland involution animal organ morphogenesis apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus positive regulation of biological process RNA metabolic process positive regulation of miRNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process organic substance metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process ncRNA metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of cellular process signaling non-canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction negative regulation of small molecule metabolic process negative regulation of calcidiol 1-monooxygenase activity regulation of catalytic activity fat-soluble vitamin metabolic process regulation of hormone biosynthetic process regulation of lipid metabolic process negative regulation of biological process negative regulation of catalytic activity vitamin biosynthetic process negative regulation of lipid biosynthetic process negative regulation of cellular metabolic process vitamin D biosynthetic process negative regulation of hormone biosynthetic process regulation of small molecule metabolic process organic substance biosynthetic process small molecule metabolic process regulation of calcidiol 1-monooxygenase activity regulation of biological quality regulation of vitamin metabolic process hormone biosynthetic process negative regulation of monooxygenase activity negative regulation of steroid metabolic process regulation of alcohol biosynthetic process regulation of hormone levels negative regulation of oxidoreductase activity negative regulation of metabolic process cellular metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process negative regulation of vitamin metabolic process regulation of molecular function biosynthetic process organic cyclic compound biosynthetic process negative regulation of alcohol biosynthetic process negative regulation of lipid metabolic process negative regulation of hormone metabolic process regulation of steroid biosynthetic process cellular biosynthetic process regulation of hormone metabolic process organic hydroxy compound metabolic process steroid metabolic process lipid biosynthetic process alcohol metabolic process negative regulation of cellular process steroid biosynthetic process regulation of biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process negative regulation of molecular function regulation of oxidoreductase activity vitamin D metabolic process regulation of vitamin D biosynthetic process hormone metabolic process vitamin metabolic process regulation of cellular biosynthetic process regulation of monooxygenase activity negative regulation of biosynthetic process organic hydroxy compound biosynthetic process fat-soluble vitamin biosynthetic process alcohol biosynthetic process negative regulation of steroid biosynthetic process regulation of lipid biosynthetic process negative regulation of vitamin D biosynthetic process lipid metabolic process organonitrogen compound metabolic process regulation of protein metabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process response to interleukin-6 cellular response to interleukin-6 JNK cascade MAPK cascade negative regulation of RNA biosynthetic process DNA-templated transcription transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of gene expression negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to interleukin-1 response to interleukin-1 organonitrogen compound biosynthetic process carbohydrate derivative metabolic process positive regulation of hyaluronan biosynthetic process glycosaminoglycan biosynthetic process carbohydrate biosynthetic process hyaluronan biosynthetic process positive regulation of carbohydrate metabolic process mucopolysaccharide metabolic process glycosaminoglycan metabolic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process hyaluronan metabolic process polysaccharide metabolic process regulation of carbohydrate metabolic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process canonical NF-kappaB signal transduction immune response-regulating cell surface receptor signaling pathway positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway B cell receptor signaling pathway regulation of response to stimulus regulation of immune response antigen receptor-mediated signaling pathway activation of immune response negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of localization lipid storage lipid localization positive regulation of lipid localization maintenance of location localization regulation of lipid storage regulation of lipid localization macromolecule localization positive regulation of lipid storage regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response negative regulation of response to stimulus regulation of inflammatory response negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus response to bacterium cellular response to lipid response to molecule of bacterial origin regulation of developmental process cellular developmental process macrophage derived foam cell differentiation regulation of cell differentiation positive regulation of developmental process foam cell differentiation positive regulation of cell differentiation cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation cellular response to tumor necrosis factor response to tumor necrosis factor regulation of DNA-templated transcription initiation transcription initiation at RNA polymerase II promoter positive regulation of DNA-templated transcription initiation positive regulation of transcription initiation by RNA polymerase II DNA-templated transcription initiation regulation of transcription initiation by RNA polymerase II negative regulation of sterol transport transport regulation of lipid transport negative regulation of transport organic hydroxy compound transport negative regulation of lipid localization sterol transport regulation of cholesterol transport regulation of sterol transport negative regulation of lipid transport regulation of transport organic substance transport negative regulation of cholesterol transport lipid transport establishment of localization cholesterol transport cellular response to nicotine response to nicotine response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus regulation of interleukin-12 production negative regulation of interleukin-12 production cytokine production regulation of cytokine production regulation of multicellular organismal process interleukin-12 production negative regulation of cytokine production negative regulation of gene expression negative regulation of multicellular organismal process positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of cell communication positive regulation of signaling response to angiotensin response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus cellular response to angiotensin cellular response to endogenous stimulus cellular response to organonitrogen compound response to hormone cellular response to hormone stimulus cellular response to virus response to virus response to muscle stretch antibacterial innate immune response defense response to bacterium	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle I-kappaB/NF-kappaB complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle I-kappaB/NF-kappaB complex intracellular protein-containing complex membrane-bounded organelle NF-kappaB p50/p65 complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle NF-kappaB complex vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen specific granule lumen secretory granule secretory vesicle vesicle specific granule mitochondrion nucleoplasm nuclear lumen extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR019817	Interferon regulatory factor, conserved site	Conserved Site
C [auth A]	IPR019471	Interferon regulatory factor-3	Domain
C [auth A]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR017855	SMAD-like domain superfamily	Homologous Superfamily
C [auth A]	IPR001346	Interferon regulatory factor, DNA-binding domain	Domain
C [auth A]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
C [auth A]	IPR033926	NFkappaB IPT domain	Domain
C [auth A]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth A]	IPR011539	Rel homology domain, DNA-binding domain	Domain
C [auth A]	IPR030495	Transcription factor p65, RHD domain, N-terminal	Domain
C [auth A]	IPR002909	IPT domain	Domain
C [auth A]	IPR030492	Rel homology domain, conserved site	Conserved Site
C [auth A]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
C [auth A]	IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR000451	NF-kappa-B/Dorsal	Family
C [auth A]	IPR032397	Rel homology dimerisation domain	Domain
C [auth A]	IPR001346	Interferon regulatory factor, DNA-binding domain	Domain
C [auth A]	IPR019817	Interferon regulatory factor, conserved site	Conserved Site
C [auth A]	IPR019471	Interferon regulatory factor-3	Domain
C [auth A]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
C [auth A]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth A]	IPR017855	SMAD-like domain superfamily	Homologous Superfamily
D [auth B]	IPR030503	Nuclear factor NF-kappa-B, p105 subunit, Rel homology domain, N-terminal	Domain
D [auth B]	IPR002909	IPT domain	Domain
D [auth B]	IPR030492	Rel homology domain, conserved site	Conserved Site
D [auth B]	IPR033926	NFkappaB IPT domain	Domain
D [auth B]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
D [auth B]	IPR002110	Ankyrin repeat	Repeat
D [auth B]	IPR000488	Death domain	Domain
D [auth B]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D [auth B]	IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily	Homologous Superfamily
D [auth B]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
D [auth B]	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
D [auth B]	IPR011539	Rel homology domain, DNA-binding domain	Domain
D [auth B]	IPR011029	Death-like domain superfamily	Homologous Superfamily
D [auth B]	IPR000451	NF-kappa-B/Dorsal	Family
D [auth B]	IPR047096	Nuclear factor NF-kappa-B p105 subunit, death domain	Domain
D [auth B]	IPR032397	Rel homology dimerisation domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A]	Pharos: Q92985	herpes simplex encephalitis, susceptibility to, 7 Hashimoto thyroiditis Hodgkins lymphoma microphthalmia with limb anomalies rheumatoid arthritis systemic sclerosis Herpes encephalitis hypothyroidism myositis skin basal cell carcinoma vitiligo herpes simplex encephalitis influenza pancreatic ductal adenocarcinoma systemic lupus erythematosus herpes simplex encephalitis, susceptibility to, 7 Hashimoto thyroiditis Hodgkins lymphoma microphthalmia with limb anomalies rheumatoid arthritis systemic sclerosis Herpes encephalitis hypothyroidism myositis skin basal cell carcinoma vitiligo herpes simplex encephalitis influenza pancreatic ductal adenocarcinoma systemic lupus erythematosus renal cell carcinoma ulcerative colitis Barrett esophagus malignant colon neoplasm chronic kidney disease ependymoma cholestasis Neoplasms, Experimental extrahepatic cholestasis skin cancer breast carcinoma chromophobe renal cell carcinoma colitis diabetic peripheral angiopathy papillary renal cell carcinoma amphetamine abuse hypertensive disorder sarcomatoid renal cell carcinoma brain cancer skin neoplasm type 2 diabetes mellitus collecting duct carcinoma cystitis alcoholic liver cirrhosis plasma cell myeloma brain ischemia mantle cell lymphoma clear cell renal carcinoma metabolic syndrome X colonic neoplasm acne ovarian cancer primary biliary cholangitis heart disease malignant glioma ureteral obstruction maturity-onset diabetes of the young oligodendroglioma astrocytic tumor renal carcinoma cancer medulloblastoma diabetic kidney disease osteoarthritis glioblastoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor benign colon neoplasm ischemia reperfusion injury schizophrenia breast cancer malignant ependymoma immunodeficiency 39 influenza systemic lupus erythematosus Inflammation malignant pancreatic neoplasm myopathy pancreatic intraductal papillary-mucinous neoplasm psoriasis amyotrophic lateral sclerosis breast carcinoma dermatomyositis glioblastoma invasive ductal breast carcinoma major depressive disorder microphthalmia with limb anomalies myositis pituitary cancer rheumatoid arthritis atopic eczema systemic sclerosis cutaneous lupus erythematosus ductal breast carcinoma in situ hypothyroidism juvenile dermatomyositis malignant mesothelioma multiple sclerosis ovarian cancer primary biliary cholangitis subependymal giant cell astrocytoma breast cancer cystic fibrosis interstitial cystitis lung adenocarcinoma
D [auth B]	Pharos: P19838	common variable immunodeficiency primary biliary cholangitis tubular adenocarcinoma granular cell carcinoma immunodeficiency, common variable, 12 brain ischemia chronic kidney disease type 2 diabetes mellitus Heat Stroke adenocarcinoma liver disease malignant colon neoplasm ulcerative colitis cribriform carcinoma of breast endogenous depression common variable immunodeficiency primary biliary cholangitis tubular adenocarcinoma granular cell carcinoma immunodeficiency, common variable, 12 brain ischemia chronic kidney disease type 2 diabetes mellitus Heat Stroke adenocarcinoma liver disease malignant colon neoplasm ulcerative colitis cribriform carcinoma of breast endogenous depression leukopenia lung cancer membranous glomerulonephritis alopecia ovarian cyst benign colon neoplasm systemic sclerosis corpus luteum cyst diabetes mellitus acute kidney failure primary hyperoxaluria tuberculosis colonic neoplasm cribriform carcinoma glioblastoma maturity-onset diabetes of the young allergic rhinitis attention deficit hyperactivity disorder, inattentive type