Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd2np5b1 All alpha proteins DNA/RNA-binding 3-helical bundle Homeodomain-like Tetracyclin repressor-like, N-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)
Bd2np5b2 All alpha proteins Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)
Ad2np5a1 All alpha proteins DNA/RNA-binding 3-helical bundle Homeodomain-like Tetracyclin repressor-like, N-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)
Ad2np5a2 All alpha proteins Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)
Cd2np5c1 All alpha proteins DNA/RNA-binding 3-helical bundle Homeodomain-like Tetracyclin repressor-like, N-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)
Cd2np5c2 All alpha proteins Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)
Dd2np5d1 All alpha proteins DNA/RNA-binding 3-helical bundle Homeodomain-like Tetracyclin repressor-like, N-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)
Dd2np5d2 All alpha proteins Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Tetracyclin repressor-like, C-terminal domain Transcriptional regulator RHA1_ro04179 (Rhodococcus jostii RHA1 ) [TaxId: 101510 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyHomeodomain-like8056427 3000001 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTetR C-terminal domain-like8056428 3000086 SCOP2B (2022-06-29)
ASCOP2 FamilyTetracyclin repressor-like8056426 4000333 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyHomeodomain-like8056427 3000001 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyTetR C-terminal domain-like8056428 3000086 SCOP2 (2022-06-29)
CSCOP2B SuperfamilyHomeodomain-like8056427 3000001 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTetR C-terminal domain-like8056428 3000086 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyTetR C-terminal domain-like8056428 3000086 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BTetR_N_2e2np5B1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_N_2ECOD (1.6)
BTetR_C_6e2np5B2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: TetR_C_6ECOD (1.6)
ATetR_N_2e2np5A1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_N_2ECOD (1.6)
ATetR_C_6e2np5A2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: TetR_C_6ECOD (1.6)
CTetR_N_2e2np5C1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_N_2ECOD (1.6)
CTetR_C_6e2np5C2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: TetR_C_6ECOD (1.6)
DTetR_N_2e2np5D1 A: alpha arraysX: HTHH: HTHT: tri-helicalF: TetR_N_2ECOD (1.6)
DTetR_C_6e2np5D2 A: alpha bundlesX: Tetracyclin repressor-like, C-terminal domain (From Topology)H: Tetracyclin repressor-like, C-terminal domain (From Topology)T: Tetracyclin repressor-like, C-terminal domainF: TetR_C_6ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)
A1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)
C1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)
D1.10.357.10 Mainly Alpha Orthogonal Bundle Tetracycline Repressor domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF13977BetI-type transcriptional repressor, C-terminal (TetR_C_6)BetI-type transcriptional repressor, C-terminalThis family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins ...This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity [1]. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli [2].
Domain
A, B, C, D
PF00440Bacterial regulatory proteins, tetR family (TetR_N)Bacterial regulatory proteins, tetR family- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Transcriptional regulator -