2NO2

Crystal structure of the DLLRKN-containing coiled-coil domain of Huntingtin-interacting protein 1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	HIP1 clathrin-binding region-like	8045693	4004621	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HIP1 clathrin-binding region-like	8091441	3002510	SCOP2 (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.250.920	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16515	Clathrin-binding domain of Huntingtin-interacting protein 1 (HIP1_clath_bdg)	Clathrin-binding domain of Huntingtin-interacting protein 1	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Huntingtin-interacting protein 1	binding phospholipid binding lipid binding phosphatidylinositol binding clathrin binding protein binding clathrin light chain binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding AP-2 adaptor complex binding ion binding anion binding binding phospholipid binding lipid binding phosphatidylinositol binding clathrin binding protein binding clathrin light chain binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding AP-2 adaptor complex binding ion binding anion binding phosphatidylinositol-3,4-bisphosphate binding small molecule binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding protein heterodimerization activity protein dimerization activity signaling receptor binding glutamate receptor binding identical protein binding protein homodimerization activity cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity epidermal growth factor receptor binding growth factor receptor binding structural constituent of cytoskeleton structural molecule activity phosphatidylinositol-3-phosphate binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication regulation of protein stability biological regulation regulation of biological quality protein stabilization trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular process regulation of localization import into cell regulation of cellular component organization regulation of transport transport regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport cellular component organization localization cellular component organization or biogenesis endocytosis regulation of endocytosis apoptotic process cell death programmed cell death regulation of apoptotic process regulation of programmed cell death cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway cell surface receptor signaling pathway regulation of response to stimulus ERBB signaling pathway positive regulation of signaling positive regulation of cellular component organization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis positive regulation of transport receptor-mediated endocytosis protein localization establishment of protein localization cellular localization nitrogen compound transport neurotransmitter receptor transport organic substance transport protein-containing complex localization protein transport cellular macromolecule localization macromolecule localization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport in synapse establishment of localization in cell regulation of postsynaptic neurotransmitter receptor internalization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis developmental process cellular developmental process cell differentiation regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process organic substance metabolic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis metabolic process macromolecule metabolic process regulation of metabolic process regulation of platelet-derived growth factor receptor signaling pathway positive regulation of platelet-derived growth factor receptor-beta signaling pathway positive regulation of platelet-derived growth factor receptor signaling pathway platelet-derived growth factor receptor-beta signaling pathway platelet-derived growth factor receptor signaling pathway regulation of platelet-derived growth factor receptor-beta signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly apoptotic signaling pathway	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane intracellular anatomical structure cytoplasm cytosol presynapse cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane intracellular anatomical structure cytoplasm cytosol presynapse presynaptic membrane membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle intracellular organelle coated vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle vesicle organelle membrane clathrin-coated vesicle membrane glutamatergic synapse Golgi apparatus endomembrane system cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle Schaffer collateral - CA1 synapse nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008942	ENTH/VHS	Homologous Superfamily
A	IPR030224	Sla2 family	Family
A	IPR002558	I/LWEQ domain	Domain
A	IPR032422	Huntingtin-interacting protein 1, clathrin-binding domain	Domain
A	IPR011417	AP180 N-terminal homology (ANTH) domain	Domain
A	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
A	IPR013809	ENTH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00291	Liver Cirrhosis, Experimental ovarian cancer primitive neuroectodermal tumor psoriasis systemic lupus erythematosus adenoma atypical teratoid rhabdoid tumor facioscapulohumeral muscular dystrophy glioblastoma lung carcinoma malignant pancreatic neoplasm oligodendroglioma pancreatic ductal adenocarcinoma prostate cancer rheumatoid arthritis Liver Cirrhosis, Experimental ovarian cancer primitive neuroectodermal tumor psoriasis systemic lupus erythematosus adenoma atypical teratoid rhabdoid tumor facioscapulohumeral muscular dystrophy glioblastoma lung carcinoma malignant pancreatic neoplasm oligodendroglioma pancreatic ductal adenocarcinoma prostate cancer rheumatoid arthritis adrenal cortex carcinoma diabetes mellitus familial prostate carcinoma large cell medulloblastoma malignant glioma medulloblastoma osteosarcoma pilocytic astrocytoma spina bifida astrocytic tumor Down syndrome gastric carcinoma malignant mesothelioma neurodegenerative disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.