2NNW

Alternative conformations of Nop56/58-fibrillarin complex and implication for induced-fit assenly of box C/D RNPs

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d2nnwd_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Fibrillarin homologue	Fibrillarin homologue	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
B	d2nnwb_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Fibrillarin homologue	Fibrillarin homologue	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8063654	3000118	SCOP2B (2022-06-29)
B	SCOP2 Family	Fibrillarin homologue	8063653	4000661	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8063654	3000118	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Nop_C	e2nnwA3	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: Nop C-terminal domain	F: Nop_C	ECOD (1.6)
A	Nop_N	e2nnwA2	A: alpha complex topology	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: Nop_N	ECOD (1.6)
A	PRK14552_1	e2nnwA1	A: mixed a+b and a/b	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: PRK14552_1	ECOD (1.6)
C	Nop_C	e2nnwC4	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: Nop C-terminal domain	F: Nop_C	ECOD (1.6)
C	Nop_N	e2nnwC3	A: alpha complex topology	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: Nop_N	ECOD (1.6)
C	PRK14552_1	e2nnwC2	A: mixed a+b and a/b	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: PRK14552_1	ECOD (1.6)
D	Fibrillarin	e2nnwD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Fibrillarin	ECOD (1.6)
B	Fibrillarin	e2nnwB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Fibrillarin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.420.220	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	1.10.287.4070	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
A	1.10.246.90	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)
C	3.30.420.220	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	1.10.287.4070	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
C	1.10.246.90	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)
D	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
D	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF21572	Archaeal Nop5/56-rel, N-terminal domain (Nop5_56-rel_N_Arc)	Archaeal Nop5/56-rel, N-terminal domain	This domain is found at the N-terminal end of a group of archaeal proteins, including Uncharacterized NOP5 family protein MJ0694 from Methanocaldococcus jannaschii. This domain interacts with fibrillarin, the other subunit of a complex that is critic ...	This domain is found at the N-terminal end of a group of archaeal proteins, including Uncharacterized NOP5 family protein MJ0694 from Methanocaldococcus jannaschii. This domain interacts with fibrillarin, the other subunit of a complex that is critical to modify and process ribosomal RNAs [1-5]. This domain shows a highly conserved folded structure despite low sequence similarity among homologs. It shows four beta-sheets surrounded by four alpha- helices [6] and is found associated with Pfam:PF01798.	Domain
A, C	PF01798	snoRNA binding domain, fibrillarin (Nop)	snoRNA binding domain, fibrillarin	-	Family
B, D	PF01269	Fibrillarin (Fibrillarin)	Fibrillarin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	NOP5/NOP56 related protein	RNA binding binding organic cyclic compound binding snoRNA binding nucleic acid binding	-	preribosome protein-containing complex ribonucleoprotein complex small-subunit processome box C/D methylation guide snoRNP complex sno(s)RNA-containing ribonucleoprotein complex box C/D RNP complex
B, D	Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase	transferase activity, transferring one-carbon groups transferase activity methyltransferase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding	methylation metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process methylation metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process cellular process macromolecule metabolic process tRNA metabolic process tRNA processing	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR042239	Nop, C-terminal domain	Homologous Superfamily
A, C	IPR036070	Nop domain superfamily	Homologous Superfamily
A, C	IPR045056	Nucleolar protein Nop56/Nop58	Family
A, C	IPR002687	Nop domain	Domain
A, C	IPR029012	Helix hairpin bin domain superfamily	Homologous Superfamily
A, C	IPR048896	Nop5/56-related, N-terminal domain	Domain
A, C	IPR012976	NOSIC	Domain
A, C	IPR047099	Nop5, N-terminal domain superfamily	Homologous Superfamily
B, D	IPR000692	rRNA 2'-O-methyltransferase fibrillarin-like	Family
B, D	IPR020813	Fibrillarin, conserved site	Conserved Site
B, D	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.