2NMB

DNUMB PTB DOMAIN COMPLEXED WITH A PHOSPHOTYROSINE PEPTIDE, NMR, ENSEMBLE OF STRUCTURES.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2nmba_	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Numb	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Phosphotyrosine-binding domain (PTB)	8030219	4002427	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8042598	3000134	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PID	e2nmbA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PID	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00640	Phosphotyrosine interaction domain (PTB/PID) (PID)	Phosphotyrosine interaction domain (PTB/PID)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (NUMB PROTEIN)	protein binding binding signaling receptor binding Notch binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding protein binding binding signaling receptor binding Notch binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division generation of neurons neurogenesis multicellular organism development asymmetric neuroblast division cell differentiation anatomical structure development developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process neuroblast division nervous system development asymmetric cell division generation of neurons neurogenesis multicellular organism development asymmetric neuroblast division cell differentiation anatomical structure development cellular process cell division neural precursor cell proliferation cell fate commitment system development regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation regulation of cell development regulation of nervous system development regulation of multicellular organismal process protein localization localization cellular localization cellular macromolecule localization macromolecule localization centrosome localization microtubule organizing center localization sensory organ development cell fate commitment involved in pattern specification pattern specification process cell fate determination animal organ formation animal organ morphogenesis cell fate determination involved in pattern specification animal organ development sensory organ boundary specification formation of anatomical boundary regionalization anatomical structure morphogenesis sensory organ precursor cell fate determination anatomical structure formation involved in morphogenesis formation of animal organ boundary negative regulation of neural precursor cell proliferation negative regulation of biological process regulation of neuroblast proliferation negative regulation of neuroblast proliferation negative regulation of neurogenesis negative regulation of cellular process negative regulation of nervous system development negative regulation of cell differentiation regulation of neural precursor cell proliferation negative regulation of cell population proliferation negative regulation of developmental process negative regulation of cell development regulation of cell population proliferation negative regulation of multicellular organismal process epithelium development tissue development epithelial cell differentiation glandular epithelial cell differentiation enteroendocrine cell differentiation columnar/cuboidal epithelial cell differentiation heart development tube development embryo development embryonic heart tube development circulatory system development embryonic organ development neuroblast differentiation neuroblast development regulation of asymmetric cell division regulation of cell division renal filtration cell differentiation renal system development pericardial nephrocyte differentiation nephrocyte differentiation cellular response to stimulus response to stimulus negative regulation of signaling signaling regulation of signal transduction negative regulation of cell communication cell communication signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication sensory organ precursor cell division muscle cell fate specification muscle cell fate commitment cell fate specification muscle cell differentiation muscle structure development Malpighian tubule development Malpighian tubule tip cell differentiation renal tubule development regulation of receptor recycling negative regulation of receptor recycling negative regulation of metabolic process regulation of macromolecule metabolic process receptor recycling organic substance metabolic process receptor metabolic process metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of macromolecule metabolic process glial cell migration gliogenesis cell migration cell motility cellular biosynthetic process negative regulation of cellular metabolic process organic substance biosynthetic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of localization import into cell positive regulation of cellular component organization regulation of cellular component organization regulation of transport transport positive regulation of biological process regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport cellular component organization positive regulation of endocytosis positive regulation of transport cellular component organization or biogenesis endocytosis positive regulation of cellular process regulation of endocytosis	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity basal part of cell membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	PROTEIN (GPPY PEPTIDE)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR006020	PTB/PI domain	Domain
A	IPR016698	Numb/numb-like	Family
A	IPR010449	NUMB domain	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.