Annotations: 2NCD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ncda_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Motor proteins	Kinesin motor Ncd (non-claret disjunctional)	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Kinesin motor domain	8031928	4004055	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	P-loop motor domain	8044306	3002036	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Kinesin	e2ncdA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Kinesin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00225	Kinesin motor domain (Kinesin)	Kinesin motor domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (Kinesin motor NCD)	hydrolase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding hydrolase activity catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding identical protein binding protein homodimerization activity protein dimerization activity microtubule motor activity cytoskeletal motor activity minus-end-directed microtubule motor activity ATP-dependent activity	cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cell division cell cycle chromosome segregation cell cycle process regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process non-membrane-bounded organelle assembly regulation of mitotic spindle organization mitotic cell cycle cellular component biogenesis cellular component assembly regulation of mitotic spindle assembly mitotic sister chromatid segregation regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization regulation of biological process mitotic nuclear division organelle assembly regulation of cell cycle process organelle fission biological regulation regulation of microtubule-based process chromosome organization sister chromatid segregation regulation of spindle organization regulation of cellular component biogenesis spindle assembly regulation of organelle organization mitotic spindle organization regulation of spindle assembly mitotic spindle assembly nuclear division mitotic cell cycle process regulation of organelle assembly nuclear chromosome segregation regulation of microtubule cytoskeleton organization regulation of chromosome segregation mitotic spindle elongation spindle elongation regulation of spindle elongation regulation of chromosome organization regulation of mitotic sister chromatid segregation regulation of sister chromatid segregation regulation of mitotic spindle elongation meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle process meiotic nuclear division meiotic cell cycle meiotic spindle organization meiotic spindle assembly female gamete generation gamete generation female meiotic nuclear division multicellular organismal reproductive process spindle assembly involved in female meiosis distributive segregation microtubule-based movement microtubule sliding minus-end directed microtubule sliding microtubule organizing center organization centrosome separation mitotic centrosome separation centrosome cycle	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol spindle meiotic spindle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol spindle meiotic spindle polymeric cytoskeletal fiber mitotic spindle spindle microtubule mitotic spindle microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR001752	Kinesin motor domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR027640	Kinesin-like protein	Family
A	IPR019821	Kinesin motor domain, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.