Annotations: 2MTG

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2mtgA1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	La-related protein 6	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding cytoskeletal protein binding protein binding myosin binding mRNA 5'-UTR binding RNA stem-loop binding sequence-specific mRNA binding	regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process RNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA processing positive regulation of biological process collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of metabolic process positive regulation of collagen metabolic process positive regulation of biosynthetic process positive regulation of collagen biosynthetic process collagen metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR024642	SUZ-C domain	Domain
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A	IPR002344	Lupus La protein	Family
A	IPR006630	La-type HTH domain	Domain
A	IPR045180	La domain containing protein	Family
A	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
A	IPR034880	La-related protein 6, RNA recognition motif	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BRS8	pancreatic ductal adenocarcinoma Pick disease progressive supranuclear palsy ulcerative colitis astrocytic tumor breast carcinoma glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma Pick disease progressive supranuclear palsy ulcerative colitis astrocytic tumor breast carcinoma glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor breast fibroadenoma invasive ductal breast carcinoma lung adenocarcinoma malignant glioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor subependymal giant cell astrocytoma breast cancer ductal breast carcinoma in situ juvenile dermatomyositis lung carcinoma malignant mesothelioma oligodendroglioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.