2M9W

Solution NMR Structure of Transcription Factor GATA-4 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR4783B

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2m9wa1	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	Erythroid transcription factor GATA-1	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2m9wa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GATA	e2m9wA1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: GATA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.50.10	Alpha Beta	2-Layer Sandwich	Erythroid Transcription Factor GATA-1	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00320	GATA zinc finger (GATA)	GATA zinc finger	This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transcription factor GATA-4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding co-SMAD binding SMAD binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding co-SMAD binding SMAD binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding NFAT protein binding kinase binding enzyme binding protein kinase binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development response to stimulus response to chemical response to xenobiotic stimulus heart development atrioventricular canal development circulatory system development digestive system development foregut morphogenesis tube development embryonic morphogenesis embryo development digestive tract development anatomical structure morphogenesis tube morphogenesis embryonic foregut morphogenesis digestive tract morphogenesis cardiac atrium morphogenesis cardiac chamber morphogenesis atrial septum secundum morphogenesis heart morphogenesis cardiac atrium development cardiac septum development cardiac septum morphogenesis cardiac chamber development atrial septum morphogenesis animal organ morphogenesis septum secundum development atrial septum development cardiac ventricle morphogenesis cardiac ventricle development regulation of biological process signaling biological regulation cell-cell signaling cellular process cell communication response to nutrient levels response to organic substance response to lipid response to nutrient response to vitamin A response to vitamin regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process tissue regeneration developmental growth cardiac muscle tissue regeneration growth regeneration cellular developmental process cell differentiation cell fate commitment negative regulation of cellular catabolic process negative regulation of catabolic process catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of catabolic process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process negative regulation of cellular process process utilizing autophagic mechanism system process cardiac muscle cell development cell development organ growth muscle cell differentiation cell growth striated muscle tissue development muscle structure development muscle cell development cardiac muscle hypertrophy cardiac cell development muscle tissue development cardiac muscle tissue growth muscle hypertrophy heart growth developmental cell growth cardiac muscle tissue development physiological muscle hypertrophy cardiac muscle cell differentiation striated muscle hypertrophy tissue development muscle system process cardiocyte differentiation cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy striated muscle cell differentiation anterior/posterior pattern specification pattern specification process regionalization embryonic heart tube anterior/posterior pattern specification negative regulation of cardiac muscle cell apoptotic process muscle cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death cardiac muscle cell apoptotic process negative regulation of apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process negative regulation of muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process apoptotic process programmed cell death negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cardiac right ventricle morphogenesis positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process mesenchyme development endocardial cushion development embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry epithelial tube morphogenesis embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis epithelium development morphogenesis of an epithelium determination of heart left/right asymmetry tissue morphogenesis left/right pattern formation heart process regulation of actin filament-based process regulation of heart contraction regulation of system process cardiac muscle contraction striated muscle contraction circulatory system process actin filament-based process regulation of multicellular organismal process blood circulation cardiac muscle cell contraction regulation of cardiac muscle contraction actin filament-based movement muscle contraction regulation of muscle system process regulation of blood circulation regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction heart contraction ventricular septum development regulation of cytokine production cytokine production regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production positive regulation of cytokine production cellular response to stimulus homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis response to glucose glucose homeostasis intestinal epithelial cell differentiation epithelial cell differentiation columnar/cuboidal epithelial cell differentiation endoderm development positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus positive regulation of signal transduction regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction positive regulation of BMP signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus signal transduction BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of signaling cell surface receptor signaling pathway regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway response to BMP regulation of response to stimulus regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway response to growth factor positive regulation of signaling heart valve development aortic valve development heart valve morphogenesis semi-lunar valve development aortic valve morphogenesis negative regulation of signaling negative regulation of cell communication negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of signal transduction apoptotic signaling pathway regulation of apoptotic signaling pathway response to mechanical stimulus response to abiotic stimulus response to external stimulus intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway intracellular signal transduction regulation of intracellular signal transduction intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis positive regulation of angiogenesis vasculature development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis wound healing response to stress response to wounding atrioventricular valve development atrioventricular valve formation heart valve formation atrioventricular valve morphogenesis septum primum development atrial septum primum morphogenesis transdifferentiation cardiac conduction system development atrioventricular node development	intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000679	Zinc finger, GATA-type	Domain
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR039355	Transcription factor GATA	Family
A	IPR008013	GATA-type transcription activator, N-terminal	Domain
A	IPR016375	Transcription factor GATA-4/5/6	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P43694	tetralogy of fallot congenital diaphragmatic hernia atrial septal defect 2 testicular anomalies with or without congenital heart disease myocardial infarction atrioventricular septal defect 4 ventricular septal defect 46,XY partial gonadal dysgenesis polycystic ovary syndrome cardiomyopathy colorectal cancer ventricular septal defect 1 atrioventricular septal defect alcohol abuse atrial fibrillation tetralogy of fallot congenital diaphragmatic hernia atrial septal defect 2 testicular anomalies with or without congenital heart disease myocardial infarction atrioventricular septal defect 4 ventricular septal defect 46,XY partial gonadal dysgenesis polycystic ovary syndrome cardiomyopathy colorectal cancer ventricular septal defect 1 atrioventricular septal defect alcohol abuse atrial fibrillation Cardiomegaly endogenous depression gastric carcinoma malignant pancreatic neoplasm atrial fibrillation, familial, 1 ovarian cancer Barrett esophagus right atrial isomerism testicular germ cell tumor esophageal adenocarcinoma Hashimoto thyroiditis 8p23.1 microdeletion syndrome intellectual disability muscle tissue disease atrial septal defect myopathy pancreatic ductal adenocarcinoma psoriasis systemic lupus erythematosus colorectal carcinoma gallbladder disease heart disease malignant mesothelioma muscular disease partial atrioventricular canal rheumatoid arthritis chronic obstructive pulmonary disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.