2M49

Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth C]	d2m49c_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2m49a_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2m49b_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth D]	d2m49d_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth C]	SCOP2B Superfamily	Cytokine	8041999	3000648	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cytokine	8041999	3000648	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8042162	3001983	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	EF-hand	8042162	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth C]	FGF	e2m49C1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
A	FGF	e2m49A1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
B	S_100	e2m49B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
C [auth D]	S_100	e2m49D1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth C]	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
A	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C [auth D]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth C]	PF00167	Fibroblast growth factor (FGF)	Fibroblast growth factor	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, c ...	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular [2]. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms [2].	Domain
B, C [auth D]	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain
B, C [auth D]	PF00036	EF hand (EF-hand_1)	EF hand	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typica ...	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth C]	Fibroblast growth factor 2	transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding receptor-receptor interaction fibroblast growth factor receptor binding growth factor receptor binding molecular function activator activity molecular function regulator activity transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding receptor-receptor interaction fibroblast growth factor receptor binding growth factor receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity chemokine binding cytokine binding identical protein binding cell adhesion molecule binding protein-containing complex binding integrin binding cytokine activity chemoattractant activity heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development cellular response to stimulus regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication cellular process signal transduction Wnt signaling pathway corticotropin hormone secreting cell differentiation head development cellular developmental process forebrain development endocrine system development pituitary gland development animal organ development gland development brain development diencephalon development nervous system development central nervous system development cell differentiation adenohypophysis development positive regulation of cerebellar granule cell precursor proliferation positive regulation of cell population proliferation positive regulation of biological process regulation of cerebellar granule cell precursor proliferation cell proliferation in external granule layer cell proliferation in hindbrain positive regulation of cellular process regulation of neural precursor cell proliferation cell population proliferation positive regulation of neural precursor cell proliferation regulation of cell population proliferation cerebellar granule cell precursor proliferation neural precursor cell proliferation hindbrain development wound healing regulation of response to external stimulus negative regulation of response to stimulus negative regulation of wound healing negative regulation of biological process response to external stimulus negative regulation of response to wounding regulation of response to wounding regulation of response to stimulus response to stress regulation of response to stress negative regulation of response to external stimulus regulation of wound healing response to wounding positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription negative regulation of cell population proliferation regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation negative regulation of cellular process heart development angiogenesis involved in coronary vascular morphogenesis coronary vasculature development coronary vasculature morphogenesis sensory organ development visual system development regulation of cell differentiation regulation of lens fiber cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation sensory system development epithelium development eye development positive regulation of epithelial cell differentiation tissue development positive regulation of lens fiber cell differentiation camera-type eye development positive regulation of multicellular organismal process lens fiber cell differentiation lens development in camera-type eye endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of vascular endothelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation vascular endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of vascular endothelial cell proliferation specification of animal organ identity pattern specification process developmental induction animal organ formation animal organ morphogenesis regulation of animal organ morphogenesis regionalization positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction organonitrogen compound catabolic process mucopolysaccharide metabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process organic substance catabolic process neuroepithelial cell differentiation positive regulation of neuroepithelial cell differentiation columnar/cuboidal epithelial cell differentiation response to fibroblast growth factor cellular response to growth factor stimulus negative regulation of signaling regulation of signal transduction negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway regulation of signaling response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction fibroblast growth factor receptor signaling pathway regulation of cell communication response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway regulation of cell motility cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration endothelial cell migration tissue migration ameboidal-type cell migration regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration cell migration cell motility regulation of epithelial cell migration locomotion regulation of cell migration involved in sprouting angiogenesis sprouting angiogenesis epithelium migration regulation of locomotion positive regulation of cell communication positive regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling endothelial cell chemotaxis to fibroblast growth factor taxis endothelial cell chemotaxis regulation of cell chemotaxis to fibroblast growth factor cell chemotaxis chemotaxis regulation of endothelial cell chemotaxis to fibroblast growth factor regulation of endothelial cell chemotaxis regulation of chemotaxis cellular response to chemical stimulus response to chemical cell chemotaxis to fibroblast growth factor positive regulation of epithelial tube formation tube formation epithelial tube formation positive regulation of morphogenesis of an epithelium regulation of morphogenesis of an epithelium regulation of epithelial tube formation epithelial tube morphogenesis morphogenesis of an epithelium tissue morphogenesis small GTPase-mediated signal transduction Ras protein signal transduction thyroid-stimulating hormone-secreting cell differentiation neurogenesis neuron differentiation neuroendocrine cell differentiation generation of neurons glandular epithelial cell differentiation regulation of cell fate commitment cell fate specification regulation of cell fate specification positive regulation of cell fate specification positive regulation of cell fate commitment cell fate commitment positive regulation of locomotion positive regulation of cell migration positive regulation of epithelial cell migration positive regulation of cell motility positive regulation of blood vessel endothelial cell migration positive regulation of endothelial cell migration positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation substantia nigra development midbrain development neural nucleus development response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus regulation of localization cellular localization inorganic ion homeostasis intracellular calcium ion homeostasis transport homeostatic process monoatomic ion transmembrane transport calcium ion homeostasis negative regulation of sequestering of calcium ion calcium ion transport metal ion transport maintenance of location in cell monoatomic cation transmembrane transport localization intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis monoatomic cation homeostasis monoatomic cation transport regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport epidermis development hair cell differentiation positive regulation of neuron differentiation inner ear development regulation of mechanoreceptor differentiation regulation of inner ear auditory receptor cell differentiation positive regulation of inner ear auditory receptor cell differentiation mechanoreceptor differentiation epidermal cell differentiation ear development positive regulation of epidermis development inner ear receptor cell differentiation positive regulation of epidermal cell differentiation regulation of epidermal cell differentiation positive regulation of mechanoreceptor differentiation inner ear auditory receptor cell differentiation regulation of inner ear receptor cell differentiation positive regulation of inner ear receptor cell differentiation regulation of epidermis development regulation of neuron differentiation regulation of sprouting angiogenesis positive regulation of sprouting angiogenesis positive regulation of angiogenesis positive regulation of vasculature development stem cell development stem cell differentiation cell development regulation of canonical Wnt signaling pathway positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process embryo development ending in birth or egg hatching embryo development neuroblast proliferation response to axon injury mammary gland epithelial cell differentiation mammary gland development mammary gland epithelium development lymphatic endothelial cell migration lymph vessel morphogenesis lymph vessel development positive regulation of gene expression regulation of growth regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation organ growth striated muscle tissue development positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth muscle tissue development positive regulation of developmental growth striated muscle cell proliferation positive regulation of heart growth heart growth regulation of developmental growth cardiac muscle tissue development positive regulation of organ growth growth positive regulation of growth positive regulation of cardiac muscle tissue growth connective tissue development chondroblast differentiation skeletal system development cartilage development positive regulation of stem cell proliferation positive regulation of cell division cell division regulation of cell division embryonic morphogenesis negative regulation of locomotion negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration negative regulation of epithelial cell migration negative regulation of cell migration negative regulation of cell motility negative regulation of multicellular organismal process positive regulation of chemotaxis positive regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of endothelial cell chemotaxis positive regulation of response to external stimulus positive regulation of cell chemotaxis to fibroblast growth factor mesonephric epithelium development kidney epithelium development nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron development nephron epithelium development ureteric bud development mesonephros development kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium regulation of fibroblast migration fibroblast migration negative regulation of fibroblast migration transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II gliogenesis glial cell differentiation positive regulation of cell migration involved in sprouting angiogenesis ossification osteoblast differentiation phosphatidylinositol 3-kinase/protein kinase B signal transduction respiratory tube development lung development respiratory system development regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation vascular associated smooth muscle cell proliferation cell-cell signaling paracrine signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction skeletal muscle satellite cell proliferation growth factor dependent regulation of skeletal muscle satellite cell proliferation regulation of skeletal muscle satellite cell proliferation skeletal muscle cell proliferation regulation of skeletal muscle cell proliferation regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of stem cell differentiation regulation of stem cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation regulation of programmed cell death eye morphogenesis regulation of retinal cell programmed cell death cell death programmed cell death involved in cell development sensory organ morphogenesis retinal cell programmed cell death programmed cell death regulation of DNA biosynthetic process positive regulation of DNA biosynthetic process DNA metabolic process positive regulation of DNA metabolic process DNA biosynthetic process regulation of DNA metabolic process cell cycle regulation of cell cycle positive regulation of nervous system development regulation of neuroblast proliferation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of neurogenesis positive regulation of cell development positive regulation of neuroblast proliferation	extracellular region extracellular space cellular anatomical entity intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B, C [auth D]	Protein S100-B	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding S100 protein binding identical protein binding protein homodimerization activity protein dimerization activity cytoskeletal protein binding tau protein binding RAGE receptor binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding S100 protein binding identical protein binding protein homodimerization activity protein dimerization activity cytoskeletal protein binding tau protein binding RAGE receptor binding signaling receptor binding calcium-dependent protein binding transition metal ion binding zinc ion binding	metabolic process adaptive thermogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus metabolic process adaptive thermogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular process positive regulation of signaling developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development behavior system process learning or memory nervous system process cognition memory cellular developmental process developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth sympathetic neuron projection extension developmental growth involved in morphogenesis generation of neurons anatomical structure morphogenesis neuron development axonogenesis axon development cell morphogenesis involved in neuron differentiation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of biological quality regulation of developmental process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of neuron differentiation cell adhesion	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen extracellular region ruffle cell projection cell leading edge plasma membrane bounded cell projection perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth C]	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
A, D [auth C]	IPR002209	Fibroblast growth factor family	Family
B, C [auth D]	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
B, C [auth D]	IPR002048	EF-hand domain	Domain
B, C [auth D]	IPR011992	EF-hand domain pair	Homologous Superfamily
B, C [auth D]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B, C [auth D]	IPR028481	Protein S100-B	Family
B, C [auth D]	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D [auth C]	Pharos: P09038	nephrotic syndrome malignant glioma essential thrombocythemia cleft palate oral submucous fibrosis cirrhosis of liver Gliosis cocaine dependence corneal neovascularization brain infarction mixed glioma gestational diabetes visual epilepsy periapical periodontitis prostate cancer nephrotic syndrome malignant glioma essential thrombocythemia cleft palate oral submucous fibrosis cirrhosis of liver Gliosis cocaine dependence corneal neovascularization brain infarction mixed glioma gestational diabetes visual epilepsy periapical periodontitis prostate cancer kidney disease pulmonary fibrosis endogenous depression melancholia cocaine abuse epilepsy with generalized tonic-clonic seizures eye disease myocardial ischemia neurotic disorder congenital diaphragmatic hernia hematologic disease ovarian cancer cystic fibrosis intestinal disease psoriasis Emery-Dreifuss muscular dystrophy lung disease breast cancer medulloblastoma breast fibroadenoma cleft lip idiopathic interstitial pneumonia coronary artery disease injury invasive ductal breast carcinoma schizophrenia Down syndrome lung adenocarcinoma brain injury breast carcinoma cancer cerebrovascular disorder ulcerative colitis nasopharyngeal carcinoma vertebral column disease glioma neurodegenerative disease non-small cell lung carcinoma depressive disorder ischemia reperfusion injury benign mesothelioma large cell medulloblastoma ductal breast carcinoma in situ lung cancer malignant mesothelioma breast disease mesothelioma
B, C [auth D]	Pharos: P04271	Down syndrome Hematoma bipolar disorder myocardial infarction oppositional defiant disorder intracranial vasospasm brain edema interstitial cystitis invasive ductal breast carcinoma malignant colon neoplasm brain injury neurodegenerative disease cerebrovascular disorder psoriasis ductal breast carcinoma in situ Down syndrome Hematoma bipolar disorder myocardial infarction oppositional defiant disorder intracranial vasospasm brain edema interstitial cystitis invasive ductal breast carcinoma malignant colon neoplasm brain injury neurodegenerative disease cerebrovascular disorder psoriasis ductal breast carcinoma in situ human African trypanosomiasis atypical teratoid rhabdoid tumor intracerebral hemorrhage brain cancer large cell medulloblastoma medulloblastoma breast cancer pneumocystosis depressive disorder schizophrenia fetal methylmercury syndrome major depressive disorder breast carcinoma pituitary cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.