2M3X

Solution structure of Ph1500: a homohexameric protein centered on a 12-bladed beta-propeller

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF20986	e2m3xA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 12-bladed	F: PF20986	ECOD (1.6)
A	PF02933	e2m3xA2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: PF02933	ECOD (1.6)
B	PF20986	e2m3xB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 12-bladed	F: PF20986	ECOD (1.6)
B	PF02933	e2m3xB2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: PF02933	ECOD (1.6)
C	PF20986	e2m3xC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 12-bladed	F: PF20986	ECOD (1.6)
C	PF02933	e2m3xC2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: PF02933	ECOD (1.6)
D	PF20986	e2m3xD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 12-bladed	F: PF20986	ECOD (1.6)
D	PF02933	e2m3xD2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: PF02933	ECOD (1.6)
E	PF20986	e2m3xE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 12-bladed	F: PF20986	ECOD (1.6)
E	PF02933	e2m3xE2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: PF02933	ECOD (1.6)
F	PF20986	e2m3xF1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 12-bladed	F: PF20986	ECOD (1.6)
F	PF02933	e2m3xF2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: PF02933	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
A	2.40.10.360	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
B	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
B	2.40.10.360	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
C	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
C	2.40.10.360	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
D	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
D	2.40.10.360	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
E	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
E	2.40.10.360	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
F	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
F	2.40.10.360	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF02933	Cell division protein 48 (CDC48), domain 2 (CDC48_2)	Cell division protein 48 (CDC48), domain 2	This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at t ...	This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate 185-residue recognition domain [1].	Domain
A, B, C, D, E A, B, C, D, E, F	PF20986	Domain of unknown function (DUF6849) (DUF6849)	Domain of unknown function (DUF6849)	This domain is found in uncharacterised archaeal proteins. It is found C-terminal to Pfam:PF02933, in CDC48 proteins. Its function is unknown.	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR029067	CDC48 domain 2-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR004201	CDC48, domain 2	Domain
A, B, C, D, E A, B, C, D, E, F	IPR049295	Domain of unknown function DUF6849	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.