2M05
Structure of module 2 from the E1 domain of C. elegans APL-1
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2m05a1 | Alpha and beta proteins (a+b) | Dodecin subunit-like | Amyloid beta a4 protein copper binding domain (domain 2) | automated matches | automated matches | nematode (Caenorhabditis elegans ) [TaxId: 6239 ], | SCOPe (2.08) |
A | d2m05a2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | nematode (Caenorhabditis elegans ) [TaxId: 6239 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF12924 | e2m05A1 | A: a+b two layers | X: Dodecin subunit-like | H: Amyloid beta a4 protein copper binding domain (domain 2) (From Topology) | T: Amyloid beta a4 protein copper binding domain (domain 2) | F: PF12924 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.1490.140 | Alpha Beta | 2-Layer Sandwich | Dna Ligase | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF12924 | Copper-binding of amyloid precursor, CuBD (APP_Cu_bd) | Copper-binding of amyloid precursor, CuBD | This short domain, part of the extra-cellular N-terminus of the amyloid precursor protein, APP, can bind both copper and zinc, CuBD. The structure of Cu2+-bound CuBD reveals that the metal ligands are His147, His151, Tyr168 and two water molecules, ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR019543 | Beta-amyloid precursor protein C-terminal | Domain | |
IPR036176 | E2 domain superfamily | Homologous Superfamily | |
IPR019744 | Amyloidogenic glycoprotein, copper-binding domain conserved site | Conserved Site | |
IPR036454 | Amyloidogenic glycoprotein, heparin-binding domain superfamily | Homologous Superfamily | |
IPR019745 | Amyloidogenic glycoprotein, intracellular domain, conserved site | Conserved Site | |
IPR011178 | Amyloidogenic glycoprotein, copper-binding | Domain | |
IPR008154 | Amyloidogenic glycoprotein, extracellular | Domain | |
IPR015849 | Amyloidogenic glycoprotein, heparin-binding | Domain | |
IPR024329 | Amyloidogenic glycoprotein, E2 domain | Domain | |
IPR011993 | PH-like domain superfamily | Homologous Superfamily | |
IPR036669 | Amyloidogenic glycoprotein, copper-binding domain superfamily | Homologous Superfamily | |
IPR008155 | Amyloidogenic glycoprotein | Family |