2LY8

The budding yeast chaperone Scm3 recognizes the partially unfolded dimer of the centromere-specific Cse4/H4 histone variant

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00125	e2ly8A3	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: PF00125	ECOD (1.6)
A	PF15511	e2ly8A2	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: PF15511	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.20.10	Mainly Alpha	Orthogonal Bundle	Histone, subunit A	Histone, subunit A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00125	Core histone H2A/H2B/H3/H4 (Histone)	Core histone H2A/H2B/H3/H4	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Budding yeast chaperone Scm3	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding centromeric DNA binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	2-micrometer plasmid partitioning plasmid partitioning cellular process plasmid maintenance cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process 2-micrometer plasmid partitioning plasmid partitioning cellular process plasmid maintenance cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process organic cyclic compound metabolic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process biosynthetic process rRNA transcription organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process rRNA metabolic process organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly chromosome organization protein-DNA complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization organelle organization cellular component assembly kinetochore assembly protein-containing complex assembly kinetochore organization cellular component organization or biogenesis centromere complex assembly protein localization protein localization to chromatin cellular localization protein localization to chromosome, centromeric region localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to CENP-A containing chromatin mitotic nuclear division organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation cell cycle chromosome segregation cell cycle process	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome non-membrane-bounded organelle 2-micrometer circle DNA extrachromosomal circular DNA extrachromosomal DNA intracellular anatomical structure chromosome cellular anatomical entity chromosomal region intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome non-membrane-bounded organelle 2-micrometer circle DNA extrachromosomal circular DNA extrachromosomal DNA protein-containing complex CENP-A containing chromatin protein-DNA complex nucleosome chromatin chromosome, centromeric core domain CENP-A containing nucleosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009072	Histone-fold	Homologous Superfamily
A	IPR007125	Histone H2A/H2B/H3	Domain
A	IPR000164	Histone H3/CENP-A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.