2LSV

The NMR high resolution structure of yeast Tah1 in complex with the Hsp90 C-terminal tail

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2lsvA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14559	Tetratricopeptide repeat (TPR_19)	Tetratricopeptide repeat	-	Repeat
B	PF00183	Hsp90 protein (HSP90)	Hsp90 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TPR repeat-containing protein associated with Hsp90	protein binding binding protein-folding chaperone binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization ribonucleoprotein complex biogenesis protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization ribonucleoprotein complex biogenesis protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular process cellular component organization or biogenesis box C/D snoRNP assembly organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process	protein-containing complex R2TP complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	ATP-dependent molecular chaperone HSP82	ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding	protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis response to oxygen levels regulation of telomere maintenance regulation of cellular component organization regulation of cellular process telomere organization regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process chromosome organization regulation of chromosome organization regulation of macromolecule metabolic process DNA metabolic process regulation of organelle organization nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process organelle organization regulation of metabolic process regulation of DNA metabolic process ribonucleoprotein complex biogenesis small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly protein-RNA complex organization box C/D snoRNP assembly positive regulation of organelle organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process regulation of telomere maintenance via telomere lengthening positive regulation of chromosome organization positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process positive regulation of cellular component organization positive regulation of biological process positive regulation of cellular metabolic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process telomere maintenance via telomerase positive regulation of DNA biosynthetic process nucleobase-containing compound biosynthetic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process positive regulation of cellular biosynthetic process 'de novo' protein folding response to osmotic stress	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR047150	SGT	Family
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR019734	Tetratricopeptide repeat	Repeat
B	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
B	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
B	IPR037196	HSP90, C-terminal domain	Homologous Superfamily
B	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
B	IPR001404	Heat shock protein Hsp90 family	Family
B	IPR019805	Heat shock protein Hsp90, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.