Annotations: 2LSQ

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ANALOG OF THE FRAGMENT 197-221 OF BETA-1 ADRENORECEPTOR	G protein-coupled amine receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity adrenergic receptor activity neurotransmitter receptor activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled neurotransmitter receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential protein binding G protein-coupled amine receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity beta-adrenergic receptor activity adrenergic receptor activity neurotransmitter receptor activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential G protein-coupled neurotransmitter receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential protein binding binding PDZ domain binding protein domain specific binding protein heterodimerization activity protein dimerization activity beta1-adrenergic receptor activity adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding alpha-2A adrenergic receptor binding	multicellular organismal process response to nutrient levels multicellular organismal-level homeostasis response to stimulus response to dietary excess homeostatic process diet induced thermogenesis metabolic process energy homeostasis adaptive thermogenesis response to stress response to abiotic stimulus response to cold response to temperature stimulus multicellular organismal process response to nutrient levels multicellular organismal-level homeostasis response to stimulus response to dietary excess homeostatic process diet induced thermogenesis metabolic process energy homeostasis adaptive thermogenesis response to stress response to abiotic stimulus response to cold response to temperature stimulus heart process system process regulation of systemic arterial blood pressure mediated by a chemical signal regulation of heart contraction regulation of system process positive regulation of biological process positive regulation of blood pressure positive regulation of blood circulation regulation of systemic arterial blood pressure by norepinephrine-epinephrine circulatory system process positive regulation of blood pressure by epinephrine-norepinephrine regulation of multicellular organismal process regulation of biological quality blood circulation regulation of heart rate regulation of biological process regulation of blood pressure biological regulation positive regulation of heart rate positive regulation of heart rate by epinephrine-norepinephrine positive regulation of heart contraction regulation of blood circulation regulation of systemic arterial blood pressure positive regulation of multicellular organismal process heart contraction rhythmic process circadian sleep/wake cycle, sleep circadian sleep/wake cycle rhythmic behavior regulation of circadian sleep/wake cycle circadian rhythm regulation of circadian rhythm regulation of behavior behavior circadian behavior sleep regulation of circadian sleep/wake cycle, sleep circadian sleep/wake cycle process positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity fear response multicellular organismal response to stress developmental process regulation of multicellular organism growth regulation of growth regulation of developmental growth negative regulation of multicellular organism growth regulation of developmental process developmental growth negative regulation of developmental process growth negative regulation of biological process multicellular organism growth negative regulation of developmental growth negative regulation of growth negative regulation of multicellular organismal process positive regulation of metabolic process regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis regulation of metabolic process cellular response to stimulus adenylate cyclase-activating adrenergic receptor signaling pathway regulation of cellular process signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation regulation of the force of heart contraction by chemical signal regulation of the force of heart contraction positive regulation of the force of heart contraction by chemical signal positive regulation of the force of heart contraction by epinephrine-norepinephrine regulation of tube diameter regulation of tube size norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure negative regulation of blood pressure negative regulation of systemic arterial blood pressure vascular process in circulatory system blood vessel diameter maintenance vasodilation regulation of anatomical structure size heat generation	membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle neuronal dense core vesicle cell periphery plasma membrane membrane early endosome endosome Schaffer collateral - CA1 synapse synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR002233	Adrenoceptor family	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A	IPR000507	Beta 1 adrenoceptor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08588	hypertensive disorder dilated cardiomyopathy endomyocardial fibrosis congestive heart failure Ventricular Dysfunction obesity disorder cardiovascular disease diabetes mellitus interstitial lung disease pilocytic astrocytoma pulmonary emphysema lung carcinoma sinusitis gastric cancer asthma hypertensive disorder dilated cardiomyopathy endomyocardial fibrosis congestive heart failure Ventricular Dysfunction obesity disorder cardiovascular disease diabetes mellitus interstitial lung disease pilocytic astrocytoma pulmonary emphysema lung carcinoma sinusitis gastric cancer asthma tuberculosis glioblastoma atopic eczema atrioventricular block heart failure bronchiectasis open-angle glaucoma osteosarcoma chronic obstructive pulmonary disease invasive ductal breast carcinoma coronary artery disease primitive neuroectodermal tumor depressive disorder dilated cardiomyopathy 1A malignant ependymoma acute coronary syndrome essential tremor malignant pancreatic neoplasm gastric neoplasm atrial fibrillation head and neck cancer myocardial infarction atypical teratoid rhabdoid tumor ventricular fibrillation bronchitis hereditary diffuse gastric adenocarcinoma ocular hypertension hypertrophic cardiomyopathy interstitial cystitis Parkinson disease common cold large cell medulloblastoma Crohn disease psoriasis lung adenocarcinoma ductal breast carcinoma in situ malignant glioma exocrine pancreatic carcinoma medulloblastoma glaucoma astrocytic tumor myocardial ischemia hemangioma non-small cell lung carcinoma cardiac arrest oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.