Annotations: 2LEF

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d2lefa_	All alpha proteins	HMG-box	HMG-box	HMG-box	Lymphoid enhancer-binding factor, LEF1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	HMG-box	8024395	4000788	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	HMG-box	8036774	3001368	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	PF00505	e2lefA1	A: alpha arrays	X: HMG-box (From Topology)	H: HMG-box (From Topology)	T: HMG-box	F: PF00505	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.10.30.10	Mainly Alpha	Orthogonal Bundle	DNA Binding (I), subunit A	High mobility group box domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF00505	HMG (high mobility group) box (HMG_box)	HMG (high mobility group) box	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	DNA (5'-D(CPAPCPCPCPTPTPTPGPAPAPGPCPTP*C)-3')	-	-	-
B [auth C]	DNA (5'-D(GPAPGPCPTPTPCPAPAPAPGPGPGPTP*G)-3')	-	-	-
C [auth A]	PROTEIN (LYMPHOID ENHANCER-BINDING FACTOR)	binding organic cyclic compound binding nucleic acid binding protein binding histone binding histone deacetylase binding enzyme binding sequence-specific DNA binding DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity binding organic cyclic compound binding nucleic acid binding protein binding histone binding histone deacetylase binding enzyme binding sequence-specific DNA binding DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity gamma-catenin binding transcription factor binding transcription coregulator binding transcription corepressor binding armadillo repeat domain binding protein domain specific binding DNA binding, bending beta-catenin binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear estrogen receptor binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity C2H2 zinc finger domain binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development neurogenesis cell differentiation anatomical structure development regulation of multicellular organismal process cellular process system development head development forebrain generation of neurons forebrain development animal organ development brain development forebrain radial glial cell differentiation generation of neurons gliogenesis central nervous system development glial cell differentiation radial glial cell differentiation cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway tongue development sensory organ development negative regulation of apoptotic process in bone marrow cell negative regulation of programmed cell death apoptotic process in bone marrow cell regulation of apoptotic process in bone marrow cell regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death response to organic substance response to cytokine response to interleukin-4 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to interleukin-4 cellular response to organic substance cell adhesion cell-cell adhesion regulation of cell adhesion regulation of cell-cell adhesion mammary gland development gland development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains mononuclear cell differentiation lymphocyte activation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response leukocyte activation alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T cell differentiation lymphocyte activation involved in immune response T-helper cell differentiation immune response hemopoiesis cell activation T cell differentiation involved in immune response T-helper 1 type immune response adaptive immune response immune effector process immune system process T-helper 1 cell differentiation leukocyte differentiation branching morphogenesis of an epithelial tube angiogenesis tube morphogenesis epithelial tube morphogenesis blood vessel development epithelium development blood vessel morphogenesis tube development morphogenesis of an epithelium tissue development vasculature development circulatory system development branching involved in blood vessel morphogenesis anatomical structure morphogenesis tissue morphogenesis morphogenesis of a branching structure anatomical structure formation involved in morphogenesis morphogenesis of a branching epithelium cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process apoptotic process involved in development apoptotic process involved in morphogenesis formation of primary germ layer mesoderm morphogenesis paraxial mesoderm formation mesenchyme morphogenesis embryonic morphogenesis mesenchyme development embryo development gastrulation paraxial mesoderm development animal organ morphogenesis paraxial mesoderm morphogenesis mesoderm formation mesoderm development somitogenesis chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process regionalization embryo development ending in birth or egg hatching somite development system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste regulation of epithelial to mesenchymal transition positive regulation of biological process positive regulation of epithelial to mesenchymal transition positive regulation of developmental process positive regulation of cell differentiation positive regulation of cellular process epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation negative regulation of interleukin-5 production regulation of interleukin-5 production regulation of cytokine production cytokine production interleukin-5 production negative regulation of cytokine production negative regulation of gene expression negative regulation of multicellular organismal process cell population proliferation B cell activation B cell proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation regulation of interleukin-4 production negative regulation of interleukin-4 production interleukin-4 production positive regulation of odontoblast differentiation epithelial cell differentiation regulation of epithelial cell differentiation neuroepithelial cell differentiation odontoblast differentiation regulation of odontoblast differentiation positive regulation of epithelial cell differentiation columnar/cuboidal epithelial cell differentiation positive regulation of neuroepithelial cell differentiation regulation of signaling regulation of Wnt signaling pathway regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of muscle tissue development negative regulation of developmental process regulation of striated muscle tissue development negative regulation of muscle tissue development striated muscle tissue development muscle structure development negative regulation of muscle organ development regulation of muscle organ development muscle tissue development muscle organ development negative regulation of striated muscle tissue development positive regulation of cell population proliferation positive regulation of cell proliferation in bone marrow cell proliferation in bone marrow regulation of cell proliferation in bone marrow regulation of cell population proliferation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion apoptotic process involved in blood vessel morphogenesis myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of granulocyte differentiation positive regulation of hemopoiesis regulation of immune system process positive regulation of immune system process regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation granulocyte differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of granulocyte differentiation positive regulation of leukocyte differentiation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process sprouting angiogenesis positive regulation of chondrocyte proliferation chondrocyte proliferation placenta development chorio-allantoic fusion labyrinthine layer development in utero embryonic development embryonic placenta morphogenesis labyrinthine layer morphogenesis embryonic placenta development embryonic organ development anatomical structure regression cell chemotaxis chemotaxis response to external stimulus taxis positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway positive regulation of signaling secondary palate development roof of mouth development positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process immune system development somatic cell DNA recombination V(D)J recombination T cell receptor V(D)J recombination somatic diversification of T cell receptor genes somatic diversification of immune receptors DNA recombination DNA metabolic process somatic diversification of immune receptors via germline recombination within a single locus somatic recombination of T cell receptor gene segments trachea submucosa development trachea gland development trachea development respiratory system development ossification osteoblast differentiation pallium development telencephalon development hippocampus development limbic system development cellular response to BMP stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to endogenous stimulus cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway regulation of leukocyte activation regulation of cell activation positive regulation of T cell differentiation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of T cell activation gamma-delta T cell activation regulation of leukocyte cell-cell adhesion regulation of gamma-delta T cell differentiation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation regulation of lymphocyte differentiation regulation of gamma-delta T cell activation positive regulation of gamma-delta T cell differentiation positive regulation of cell adhesion regulation of T cell activation gamma-delta T cell differentiation positive regulation of gamma-delta T cell activation positive regulation of lymphocyte differentiation regulation of lymphocyte activation neutrophil differentiation face morphogenesis head morphogenesis face development body morphogenesis odontogenesis of dentin-containing tooth odontogenesis protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization epithelial cell apoptotic process cell morphogenesis formation of radial glial scaffolds hindbrain radial glia guided cell migration hindbrain development cell migration in hindbrain limb development appendage development embryonic limb morphogenesis embryonic appendage morphogenesis appendage morphogenesis limb morphogenesis neuroblast proliferation forebrain neuroblast division neuroblast division cell division neural precursor cell proliferation dentate gyrus development interleukin-13 production negative regulation of interleukin-13 production regulation of interleukin-13 production regulation of cell cycle process positive regulation of cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process	protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle organelle beta-catenin-TCF complex membrane-enclosed lumen protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle organelle beta-catenin-TCF complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR027397	Catenin binding domain superfamily	Homologous Superfamily
C [auth A]	IPR036910	High mobility group box domain superfamily	Homologous Superfamily
C [auth A]	IPR013558	CTNNB1 binding, N-teminal	Domain
C [auth A]	IPR024940	Transcription factor TCF/LEF	Family
C [auth A]	IPR009071	High mobility group box domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.