Annotations: 2L7U

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	I-set_15	e2l7uA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_15	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08205	CD80-like C2-set immunoglobulin domain (C2-set_2)	CD80-like C2-set immunoglobulin domain	These domains belong to the immunoglobulin superfamily.	Domain
A	PF00047	Immunoglobulin domain (ig)	Immunoglobulin domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prot ...	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.	Domain
B	PF00273	Serum albumin family (Serum_albumin)	Serum albumin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Advanced glycosylation end product-specific receptor	amide binding amyloid-beta binding binding peptide binding cargo receptor activity scavenger receptor activity cell adhesion molecule binding laminin receptor activity protein binding cell adhesion mediator activity molecular transducer activity signaling receptor activity advanced glycation end-product receptor activity protein-containing complex binding amide binding amyloid-beta binding binding peptide binding cargo receptor activity scavenger receptor activity cell adhesion molecule binding laminin receptor activity protein binding cell adhesion mediator activity molecular transducer activity signaling receptor activity advanced glycation end-product receptor activity protein-containing complex binding molecular adaptor activity identical protein binding transmembrane signaling receptor activity S100 protein binding	negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling biological regulation cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication cellular process positive regulation of signaling positive regulation of locomotion regulation of cell motility positive regulation of monocyte extravasation positive regulation of cell migration monocyte extravasation positive regulation of cell motility cellular extravasation myeloid leukocyte migration regulation of cell migration positive regulation of mononuclear cell migration cell migration regulation of immune system process cell motility regulation of mononuclear cell migration positive regulation of immune system process locomotion regulation of leukocyte migration positive regulation of leukocyte migration leukocyte migration immune system process regulation of locomotion mononuclear cell migration regulation of monocyte extravasation regulation of cellular extravasation positive regulation of cellular extravasation regulation of leukocyte differentiation multicellular organismal process cellular developmental process regulation of developmental process cell development mononuclear cell differentiation regulation of cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of hemopoiesis positive regulation of cell differentiation cell differentiation anatomical structure development regulation of multicellular organismal process developmental process regulation of multicellular organismal development hemopoiesis positive regulation of cell development regulation of dendritic cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process dendritic cell differentiation positive regulation of leukocyte differentiation positive regulation of dendritic cell differentiation leukocyte differentiation interleukin-1 production cellular biosynthetic process positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-1 production cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process interleukin-1 beta production positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains leukocyte mediated immunity regulation of T cell mediated immunity T cell mediated cytotoxicity immune response regulation of adaptive immune response regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity adaptive immune response immune effector process regulation of T cell mediated cytotoxicity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus regulation of immune response regulation of cell killing cell killing cellular response to stimulus positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette signal transduction positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade regulation of chemokine production chemokine production positive regulation of chemokine production positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription astrocyte differentiation astrocyte activation glial cell development neurogenesis astrocyte development gliogenesis response to stress system development defense response cell activation nervous system development central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response response to wounding protein localization localization cellular localization cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-cell adhesion heterotypic cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion system process circulatory system process transport vascular process in circulatory system vascular transport establishment of localization transport across blood-brain barrier regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation regulation of T cell activation lymphocyte activation leukocyte activation regulation of CD4-positive, alpha-beta T cell activation T cell activation CD4-positive, alpha-beta T cell activation alpha-beta T cell activation regulation of lymphocyte activation myeloid leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation plasma membrane bounded cell projection organization cell projection organization neuron projection development cellular component organization generation of neurons neuron differentiation neuron development cellular component organization or biogenesis regulation of endothelin production positive regulation of endothelin production endothelin production hexose mediated signaling response to organic substance homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose sugar mediated signaling pathway glucose mediated signaling pathway cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis response to glucose response to chemical glucose homeostasis carbohydrate mediated signaling positive chemotaxis chemotaxis regulation of response to external stimulus positive regulation of positive chemotaxis response to external stimulus induction of positive chemotaxis regulation of chemotaxis positive regulation of chemotaxis regulation of positive chemotaxis positive regulation of response to external stimulus taxis positive regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production spontaneous synaptic transmission regulation of spontaneous synaptic transmission amyloid precursor protein catabolic process regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity regulation of amyloid precursor protein catabolic process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process regulation of proteolysis regulation of aspartic-type peptidase activity proteolysis regulation of endopeptidase activity protein metabolic process amyloid precursor protein metabolic process organonitrogen compound metabolic process positive regulation of aspartic-type peptidase activity regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity positive regulation of hydrolase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis positive regulation of amyloid precursor protein catabolic process regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production regulation of monocyte chemotactic protein-1 production positive regulation of monocyte chemotactic protein-1 production monocyte chemotactic protein-1 production negative regulation of interleukin-10 production interleukin-10 production negative regulation of cellular metabolic process negative regulation of cellular process regulation of interleukin-10 production negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process non-canonical NF-kappaB signal transduction regulation of non-canonical NF-kappaB signal transduction response to organonitrogen compound response to nitrogen compound response to amyloid-beta positive regulation of cell population proliferation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion leukocyte proliferation leukocyte cell-cell adhesion activated T cell proliferation positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell proliferation regulation of mononuclear cell proliferation cell surface receptor signaling pathway regulation of defense response regulation of inflammatory response regulation of response to stress p38MAPK cascade regulation of p38MAPK cascade transcytosis vesicle-mediated transport regulation of system process negative regulation of blood circulation regulation of blood circulation blood circulation behavior learning or memory nervous system process cognition negative regulation of signaling negative regulation of synaptic transmission negative regulation of cell communication negative regulation of long-term synaptic depression long-term synaptic depression regulation of long-term synaptic depression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of p38MAPK cascade positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production cellular response to nitrogen compound response to endogenous stimulus cellular response to amyloid-beta cellular response to endogenous stimulus cellular response to organonitrogen compound	postsynapse synapse cell junction cellular anatomical entity cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane cell surface extracellular region membrane-bounded organelle intracellular anatomical structure postsynapse synapse cell junction cellular anatomical entity cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane cell surface extracellular region membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen fibrillar center organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle
B	Serum albumin peptide	DNA binding binding organic cyclic compound binding nucleic acid binding vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding DNA binding binding organic cyclic compound binding nucleic acid binding vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding monocarboxylic acid binding toxic substance binding macrolide binding enterobactin binding cation binding metal ion binding	cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress cellular process response to starvation cellular response to starvation regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress cellular process response to starvation cellular response to starvation regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential cellular response to calcium ion starvation	extracellular region cellular anatomical entity intracellular anatomical structure cytoplasm extracellular space protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR013151	Immunoglobulin	Domain
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR013162	CD80-like, immunoglobulin C2-set	Domain
B	IPR020857	Serum albumin, conserved site	Conserved Site
B	IPR000264	ALB/AFP/VDB	Family
B	IPR014760	Serum albumin, N-terminal	Domain
B	IPR020858	Serum albumin-like	Homologous Superfamily
B	IPR021177	Serum albumin/Alpha-fetoprotein/Afamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q15109	rheumatoid arthritis hyperglycemia neuralgia Inflammation atherosclerosis Lewy body dementia lung carcinoma diabetic peripheral angiopathy prostate carcinoma inborn carbohydrate metabolic disorder lung adenocarcinoma squamous cell lung carcinoma malignant glioma membranous glomerulonephritis age-related macular degeneration rheumatoid arthritis hyperglycemia neuralgia Inflammation atherosclerosis Lewy body dementia lung carcinoma diabetic peripheral angiopathy prostate carcinoma inborn carbohydrate metabolic disorder lung adenocarcinoma squamous cell lung carcinoma malignant glioma membranous glomerulonephritis age-related macular degeneration autism spectrum disorder chronic obstructive pulmonary disease osteoarthritis osteosarcoma hepatitis B virus infection psoriasis sarcoidosis lung cancer systemic lupus erythematosus malignant mesothelioma ulcerative colitis colorectal cancer osteoarthritis susceptibility 1 glioblastoma pancreas disease psoriatic arthritis schizophrenia systemic sclerosis wet macular degeneration arteriosclerosis disorder atopic eczema cervical cancer non-small cell lung carcinoma heart disease

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	KPI	Parent Component: LYS RESID: AA0287 PSI-MOD : N6-pyruvic acid 2-iminyl-L-lysine MOD:00292

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.