Annotations: 2L1C

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8037874	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00640	e2l1cA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00640	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00640	Phosphotyrosine interaction domain (PTB/PID) (PID)	Phosphotyrosine interaction domain (PTB/PID)	-	Domain
B	PF08725	Integrin beta cytoplasmic domain (Integrin_b_cyt)	Integrin beta cytoplasmic domain	Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the ...	Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SHC (Src homology 2 domain containing) transforming protein 1, isoform CRA_d	transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding molecular adaptor activity signaling adaptor activity protein binding signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity insulin receptor binding transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding molecular adaptor activity signaling adaptor activity protein binding signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity insulin receptor binding phospholipid binding lipid binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding neurotrophin TRK receptor binding neurotrophin TRKA receptor binding cytokine receptor binding neurotrophin receptor binding ephrin receptor binding epidermal growth factor receptor binding growth factor receptor binding growth factor binding epidermal growth factor binding hormone binding insulin-like growth factor receptor binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling blood vessel morphogenesis tube development angiogenesis vasculature development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation ERBB signaling pathway epidermal growth factor receptor signaling pathway cellular response to nitrogen compound response to organic substance response to peptide hormone insulin receptor signaling pathway cellular response to endogenous stimulus response to hormone cellular response to organic substance cellular response to hormone stimulus response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular response to insulin stimulus cellular response to growth factor stimulus response to growth factor positive regulation of cell proliferation in bone marrow cell proliferation in bone marrow regulation of cell proliferation in bone marrow reactive oxygen species metabolic process regulation of superoxide metabolic process superoxide metabolic process regulation of reactive oxygen species metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cell adhesion cell-cell adhesion regulation of developmental process regulation of vasculature development regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis negative regulation of vasculature development regulation of angiogenesis negative regulation of multicellular organismal process	Shc-EGFR complex cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity anchoring junction cell junction focal adhesion cell-substrate junction intracellular anatomical structure cytoplasm Shc-EGFR complex cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity anchoring junction cell junction focal adhesion cell-substrate junction intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle
B	Integrin beta-3	protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding protein-containing complex binding fibrinogen binding cation binding ion binding metal ion binding small molecule binding cell adhesion molecule binding enzyme binding protease binding protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding protein-containing complex binding fibrinogen binding cation binding ion binding metal ion binding small molecule binding cell adhesion molecule binding enzyme binding protease binding cytokine receptor binding vascular endothelial growth factor receptor binding vascular endothelial growth factor receptor 2 binding molecular transducer activity coreceptor activity signaling receptor activity isomerase activity intramolecular oxidoreductase activity catalytic activity, acting on a protein intramolecular oxidoreductase activity, transposing S-S bonds catalytic activity protein disulfide isomerase activity fibronectin binding identical protein binding virus receptor activity exogenous protein binding extracellular matrix binding integrin binding kinase binding protein kinase C binding protein kinase binding	cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical cellular process cellular response to organic substance cellular response to insulin-like growth factor stimulus cellular response to hormone stimulus regulation of biological process regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cell-substrate adhesion positive regulation of cell-matrix adhesion cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion regulation of cell-matrix adhesion positive regulation of cellular process regulation of localization negative regulation of lipid transport transport regulation of transport organic substance transport negative regulation of biological process lipid localization lipid transport negative regulation of transport regulation of lipid transport establishment of localization negative regulation of lipid localization localization regulation of lipid localization macromolecule localization substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading regulation of substrate adhesion-dependent cell spreading positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion cell surface receptor signaling pathway signaling platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway multicellular organismal process regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation regulation of biological quality response to wounding platelet activation cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation developmental process epithelium development morphogenesis of an epithelium epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis anatomical structure development epiboly wound healing, spreading of cells chemotaxis negative chemotaxis taxis response to external stimulus regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation cellular localization regulation of postsynaptic neurotransmitter receptor diffusion trapping localization within membrane protein-containing complex localization neurotransmitter receptor diffusion trapping regulation of postsynaptic membrane neurotransmitter receptor levels regulation of cellular localization receptor diffusion trapping receptor localization to synapse postsynaptic neurotransmitter receptor diffusion trapping regulation of receptor localization to synapse cellular response to xenobiotic stimulus response to xenobiotic stimulus lipoprotein metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process negative regulation of cellular process regulation of lipoprotein metabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of lipoprotein metabolic process organonitrogen compound metabolic process regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process metabolic process macromolecule metabolic process regulation of metabolic process biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction import into cell phagocytosis apoptotic cell clearance endocytosis vesicle-mediated transport multicellular organism development tube development positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling monoamine transport nitrogen compound transport serotonin uptake organic hydroxy compound transport establishment of localization in cell neurotransmitter reuptake regulation of neurotransmitter uptake regulation of neurotransmitter transport regulation of serotonin uptake serotonin transport neurotransmitter transport neurotransmitter uptake trophoblast cell migration multi-multicellular organism process regulation of trophoblast cell migration reproductive process ameboidal-type cell migration female pregnancy embryo implantation multi-organism reproductive process regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization response to activity cellular biosynthetic process protein maturation blood coagulation, fibrin clot formation organic substance biosynthetic process protein activation cascade gene expression macromolecule biosynthetic process biosynthetic process cell adhesion mediated by integrin extracellular matrix organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-substrate junction assembly cell-substrate junction organization response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus protein localization regulation of protein localization cellular macromolecule localization formation of primary germ layer mesodermal cell differentiation cellular developmental process mesoderm morphogenesis embryonic morphogenesis embryo development gastrulation cell differentiation anatomical structure formation involved in morphogenesis mesoderm formation mesoderm development negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation maintenance of synapse structure postsynapse organization cellular component maintenance cell junction maintenance maintenance of postsynaptic specialization structure postsynaptic density organization synapse organization postsynaptic specialization organization regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of biosynthetic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cellular biosynthetic process cellular response to growth factor stimulus regulation of vascular endothelial growth factor receptor signaling pathway regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway response to growth factor homotypic cell-cell adhesion platelet aggregation cell-cell adhesion homeostatic process regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis regulation of multicellular organismal process lipid storage maintenance of location regulation of lipid storage negative regulation of lipid storage regulation of catalytic activity regulation of transferase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity positive regulation of molecular function positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity negative regulation of endocytosis regulation of endocytosis negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis negative regulation of molecular function regulation of vesicle-mediated transport negative regulation of low-density lipoprotein receptor activity receptor-mediated endocytosis regulation of lymphocyte migration positive regulation of mononuclear cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process positive regulation of lymphocyte migration regulation of leukocyte migration positive regulation of T cell migration lymphocyte migration positive regulation of leukocyte migration leukocyte migration immune system process regulation of T cell migration mononuclear cell migration T cell migration positive regulation of multicellular organismal process positive regulation of bone resorption heterotypic cell-cell adhesion regulation of calcium ion transport intracellular calcium ion homeostasis calcium ion transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis inorganic ion homeostasis monoatomic ion transmembrane transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol sequestering of calcium ion cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport blood vessel morphogenesis angiogenesis involved in wound healing angiogenesis vasculature development circulatory system development tube morphogenesis blood vessel development system development receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport in synapse regulation of postsynaptic neurotransmitter receptor internalization neurotransmitter receptor internalization postsynaptic endocytosis regulation of developmental process negative regulation of developmental process macrophage derived foam cell differentiation regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation endothelial cell migration positive regulation of epithelial cell migration tissue migration regulation of endothelial cell migration epithelial cell migration regulation of epithelial cell migration epithelium migration positive regulation of endothelial cell migration cellular response to platelet-derived growth factor stimulus response to platelet-derived growth factor apolipoprotein A-I-mediated signaling pathway connective tissue development renal system development kidney vasculature development renal system vasculature development positive regulation of glomerular mesangial cell proliferation regulation of glomerular mesangial cell proliferation nephron development positive regulation of cell proliferation involved in kidney development animal organ development cell proliferation involved in kidney development glomerular mesangium development regulation of cell proliferation involved in kidney development glomerulus development glomerular mesangial cell proliferation glomerulus vasculature development kidney development fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration integrin-mediated signaling pathway positive regulation of cell adhesion mediated by integrin regulation of cell adhesion mediated by integrin regulation of vasculature development positive regulation of developmental process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis regulation of opioid receptor signaling pathway positive regulation of opioid receptor signaling pathway G protein-coupled opioid receptor signaling pathway regulation of G protein-coupled receptor signaling pathway positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway adenylate cyclase-inhibiting opioid receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway	cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex alphav-beta3 integrin-HMGB1 complex receptor complex focal adhesion cell-substrate junction cell-cell junction anchoring junction cell junction cellular anatomical entity cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex alphav-beta3 integrin-HMGB1 complex receptor complex focal adhesion cell-substrate junction apical part of cell plasma membrane region apical plasma membrane ruffle cell leading edge leading edge membrane plasma membrane bounded cell projection cell projection ruffle membrane cell projection membrane cell surface integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion lamellipodium membrane lamellipodium membrane-bounded organelle intracellular anatomical structure platelet alpha granule membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane platelet alpha granule secretory granule membrane postsynapse postsynaptic membrane synapse synaptic membrane alphav-beta3 integrin-PKCalpha complex external side of plasma membrane side of membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle actin-based cell projection microvillus microvillus membrane glutamatergic synapse alphav-beta3 integrin-IGF-1-IGF1R complex integrin alphav-beta3 complex pigment granule melanosome alphav-beta3 integrin-vitronectin complex glycinergic synapse nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen alpha9-beta1 integrin-ADAM8 complex filopodium membrane filopodium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR035676	SH2 adaptor protein C, SH2 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR006020	PTB/PI domain	Domain
A	IPR006019	Phosphotyrosine interaction domain, Shc-like	Domain
B	IPR033760	Integrin beta N-terminal	Domain
B	IPR013111	EGF-like domain, extracellular	Domain
B	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B	IPR032695	Integrin domain superfamily	Homologous Superfamily
B	IPR002369	Integrin beta subunit, VWA domain	Domain
B	IPR040622	Integrin beta, epidermal growth factor-like domain 1	Domain
B	IPR036349	Integrin beta tail domain superfamily	Homologous Superfamily
B	IPR014836	Integrin beta subunit, cytoplasmic domain	Domain
B	IPR012896	Integrin beta subunit, tail	Domain
B	IPR015812	Integrin beta subunit	Family
B	IPR016201	PSI domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P29353	Cardiomegaly amyotrophic lateral sclerosis type 1 pituitary cancer skin basal cell carcinoma astrocytic tumor atypical teratoid rhabdoid tumor glioblastoma malignant glioma ovarian carcinoma plasma cell myeloma subependymal giant cell astrocytoma atrial fibrillation breast carcinoma cutaneous melanoma inflammatory bowel disease Cardiomegaly amyotrophic lateral sclerosis type 1 pituitary cancer skin basal cell carcinoma astrocytic tumor atypical teratoid rhabdoid tumor glioblastoma malignant glioma ovarian carcinoma plasma cell myeloma subependymal giant cell astrocytoma atrial fibrillation breast carcinoma cutaneous melanoma inflammatory bowel disease medulloblastoma pancreatic ductal adenocarcinoma prostate carcinoma attention deficit hyperactivity disorder, inattentive type drug-induced liver injury juvenile dermatomyositis ovarian cancer
B	Pharos: P05106	Glanzmann thrombasthenia 1 platelet-type bleeding disorder 16 carotid artery thrombosis coronary thrombosis thrombocytopenia acute coronary syndrome intracerebral hemorrhage myocardial infarction prostate cancer Gliosis osteopetrosis neonatal thrombocytopenia schizophrenia Glanzmann thrombasthenia glioblastoma Glanzmann thrombasthenia 1 platelet-type bleeding disorder 16 carotid artery thrombosis coronary thrombosis thrombocytopenia acute coronary syndrome intracerebral hemorrhage myocardial infarction prostate cancer Gliosis osteopetrosis neonatal thrombocytopenia schizophrenia Glanzmann thrombasthenia glioblastoma hip fracture tuberculosis malignant glioma autism ovarian cancer cerebrovascular disorder peripheral neuropathy spondyloarthropathy interstitial cystitis malignant mesothelioma autism spectrum disorder autosomal dominant macrothrombocytopenia pilocytic astrocytoma hypothyroidism malignant colon neoplasm malignant pancreatic neoplasm breast cancer osteosarcoma peripheral nervous system disease congenital anemia exocrine pancreatic carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.