2KZR

Solution NMR Structure of Ubiquitin thioesterase OTU1 (EC 3.1.2.-) from Mus musculus, Northeast Structural Genomics Consortium Target MmT2A

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21403	e2kzrA1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF21403	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21403	OTU1, UBXL domain (OTU1_UBXL)	OTU1, UBXL domain	OTU1 is a deubiquitinating enzyme that may play an important regulatory role at the level of protein turnover by preventing degradation. This entry represents the ubiquitin regulatory X-like (UBXL) which interacts with the N-terminal domain of VCP [1 ...	OTU1 is a deubiquitinating enzyme that may play an important regulatory role at the level of protein turnover by preventing degradation. This entry represents the ubiquitin regulatory X-like (UBXL) which interacts with the N-terminal domain of VCP [1] and removes ubiquitin chains using the OTU domain. This domain is also found in VCIP1, a known UBXL-containing protein that functions in p97/p47-mediated Golgi reassembly.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ubiquitin thioesterase OTU1	cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity K48-linked deubiquitinase activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity K48-linked deubiquitinase activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding cation binding ion binding metal ion binding small molecule binding	protein deubiquitination organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification protein K27-linked deubiquitination metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal cellular catabolic process protein deubiquitination organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification protein K27-linked deubiquitination metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy cellular process process utilizing autophagic mechanism protein K11-linked deubiquitination protein K48-linked deubiquitination protein K29-linked deubiquitination protein K33-linked deubiquitination protein localization cellular response to stimulus negative regulation of protein transport regulation of localization establishment of protein localization response to organic substance nitrogen compound transport regulation of cellular process response to stimulus negative regulation of biological process negative regulation of intracellular protein transport negative regulation of transport localization ERAD pathway proteolysis establishment of localization in cell cellular macromolecule localization negative regulation of protein exit from endoplasmic reticulum regulation of intracellular transport response to endoplasmic reticulum stress organonitrogen compound catabolic process regulation of biological process response to organonitrogen compound organic substance transport negative regulation of establishment of protein localization intracellular transport response to nitrogen compound establishment of localization response to chemical regulation of intracellular protein transport intracellular protein transport regulation of protein exit from endoplasmic reticulum protein exit from endoplasmic reticulum cellular localization regulation of protein localization transport proteolysis involved in protein catabolic process macromolecule catabolic process regulation of retrograde protein transport, ER to cytosol cellular response to stress response to stress negative regulation of cellular process negative regulation of protein localization negative regulation of intracellular transport endoplasmic reticulum to cytosol transport regulation of transport biological regulation regulation of establishment of protein localization proteasomal protein catabolic process regulation of protein transport protein catabolic process protein transport regulation of cellular localization macromolecule localization retrograde protein transport, ER to cytosol negative regulation of retrograde protein transport, ER to cytosol organic substance catabolic process protein K63-linked deubiquitination cellular response to topologically incorrect protein signaling endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein cell communication cellular response to chemical stimulus response to topologically incorrect protein signal transduction cellular response to organic substance	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013087	Zinc finger C2H2-type	Domain
A	IPR003323	OTU domain	Domain
A	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR048857	OTU1, Ubl domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.