Annotations: 2KZ7

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2kz7a_	Multi-domain proteins (alpha and beta)	Subunits of heterodimeric actin filament capping protein Capz	Subunits of heterodimeric actin filament capping protein Capz	Capz alpha-1 subunit	Capz alpha-1 subunit	bantam,chickens (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d2kz7b_	Multi-domain proteins (alpha and beta)	Subunits of heterodimeric actin filament capping protein Capz	Subunits of heterodimeric actin filament capping protein Capz	Capz beta-1 subunit	Capz beta-1 subunit	bantam,chickens (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Subunits of heterodimeric actin filament capping protein Capz	8032214	3001499	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Subunits of heterodimeric actin filament capping protein Capz	8032215	3001499	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	CARMIL uncapping motif-like	8052013	3002080	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01267	e2kz7A1	A: alpha bundles	X: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	H: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	T: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz	F: PF01267	ECOD (1.6)
A	PF01267	e2kz7A2	A: a+b two layers	X: a+b domain in Capz (From Topology)	H: a+b domain in Capz (From Topology)	T: a+b domain in Capz	F: PF01267	ECOD (1.6)
A	PF01267	e2kz7A3	A: few secondary structure elements	X: beta-barrel domain in Capz (From Topology)	H: beta-barrel domain in Capz (From Topology)	T: beta-barrel domain in Capz	F: PF01267	ECOD (1.6)
B	PF01115	e2kz7B1	A: alpha bundles	X: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	H: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	T: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz	F: PF01115	ECOD (1.6)
B	PF01115	e2kz7B3	A: a+b two layers	X: a+b domain in Capz (From Topology)	H: a+b domain in Capz (From Topology)	T: a+b domain in Capz	F: PF01115	ECOD (1.6)
B	PF01115	e2kz7B2	A: few secondary structure elements	X: beta-barrel domain in Capz (From Topology)	H: beta-barrel domain in Capz (From Topology)	T: beta-barrel domain in Capz	F: PF01115	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1140.60	Alpha Beta	2-Layer Sandwich	Ribosomal protein S3 C-terminal domain	F-actin capping protein, alpha subunit	CATH (4.3.0)
A	3.90.1150.210	Alpha Beta	Alpha-Beta Complex	Aspartate Aminotransferase, domain 1	F-actin capping protein, beta subunit	CATH (4.3.0)
B	1.20.58.570	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	3.90.1150.210	Alpha Beta	Alpha-Beta Complex	Aspartate Aminotransferase, domain 1	F-actin capping protein, beta subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01267	F-actin capping protein alpha subunit (F-actin_cap_A)	F-actin capping protein alpha subunit	-	Family
B	PF01115	F-actin capping protein, beta subunit (F_actin_cap_B)	F-actin capping protein, beta subunit	-	Family
C	PF16000	CARMIL C-terminus (CARMIL_C)	CARMIL C-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	F-actin-capping protein subunit alpha-1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding	cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular process cellular component organization or biogenesis regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular process cellular component organization or biogenesis regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization actin filament capping actin filament-based process negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly regulation of biological process barbed-end actin filament capping negative regulation of cellular component organization actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization biological regulation regulation of actin polymerization or depolymerization regulation of cellular component biogenesis organelle organization negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization protein depolymerization cytoskeleton organization regulation of anatomical structure size	protein-containing complex intracellular anatomical structure WASH complex cytoplasm cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril protein-containing complex intracellular anatomical structure WASH complex cytoplasm cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoskeleton F-actin capping protein complex actin cytoskeleton cytosol cell periphery plasma membrane membrane
B	F-actin-capping protein subunit beta isoforms 1 and 2	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding	lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly developmental process anatomical structure morphogenesis regulation of biological process lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly developmental process anatomical structure morphogenesis regulation of biological process regulation of developmental process anatomical structure development biological regulation cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis filopodium assembly regulation of cellular component organization regulation of cellular process negative regulation of filopodium assembly negative regulation of biological process regulation of filopodium assembly negative regulation of plasma membrane bounded cell projection assembly negative regulation of cellular process negative regulation of cell projection organization negative regulation of cellular component organization regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly regulation of plasma membrane bounded cell projection organization organelle organization cytoskeleton organization regulation of lamellipodium assembly regulation of lamellipodium organization regulation of cellular component size protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization actin filament capping actin filament-based process negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly barbed-end actin filament capping actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization protein depolymerization regulation of anatomical structure size	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium protein-containing complex intracellular anatomical structure WASH complex cytoplasm membrane Z disc sarcomere intracellular organelle I band cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium protein-containing complex intracellular anatomical structure WASH complex cytoplasm membrane Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytosol cluster of actin-based cell projections brush border membrane-bounded organelle sperm connecting piece cilium 9+2 motile cilium sperm flagellum motile cilium neuron to neuron synapse synapse cell junction hippocampal mossy fiber to CA3 synapse cytoskeleton F-actin capping protein complex actin cytoskeleton postsynaptic density postsynapse postsynaptic specialization asymmetric synapse Schaffer collateral - CA1 synapse cell cortex cortical cytoskeleton cell periphery
C	Leucine-rich repeat-containing protein 16A	protein-containing complex binding binding	lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly positive regulation of substrate adhesion-dependent cell spreading regulation of biological process regulation of cellular process lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly positive regulation of substrate adhesion-dependent cell spreading regulation of biological process regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion biological regulation positive regulation of biological process cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading positive regulation of cellular process cell migration cell motility positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization positive regulation of cellular component organization regulation of actin filament-based process regulation of cellular component size protein-containing complex disassembly positive regulation of actin filament depolymerization regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization actin filament-based process regulation of biological quality positive regulation of protein-containing complex disassembly cellular component disassembly actin polymerization or depolymerization regulation of actin filament organization actin cytoskeleton organization protein-containing complex organization regulation of protein depolymerization positive regulation of protein depolymerization positive regulation of cytoskeleton organization actin filament organization regulation of actin polymerization or depolymerization positive regulation of supramolecular fiber organization actin filament uncapping regulation of organelle organization barbed-end actin filament uncapping organelle organization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization protein depolymerization cytoskeleton organization regulation of anatomical structure size negative regulation of biological process actin filament capping positive regulation of protein polymerization negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization barbed-end actin filament capping negative regulation of cellular component organization negative regulation of barbed-end actin filament capping negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of barbed-end actin filament capping regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization protein polymerization actin filament polymerization negative regulation of cytoskeleton organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis negative regulation of organelle organization negative regulation of actin filament depolymerization positive regulation of actin filament polymerization establishment or maintenance of cell polarity positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion ruffle organization localization import into cell macropinocytosis transport pinocytosis endocytosis establishment of localization vesicle-mediated transport actin filament network formation organic cyclic compound metabolic process organic substance metabolic process organonitrogen compound metabolic process small molecule metabolic process metabolic process urate metabolic process purine-containing compound metabolic process regulation of Arp2/3 complex-mediated actin nucleation regulation of actin nucleation Arp2/3 complex-mediated actin nucleation actin nucleation regulation of cell projection organization positive regulation of lamellipodium organization regulation of lamellipodium organization positive regulation of cell projection organization regulation of plasma membrane bounded cell projection organization regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly stress fiber assembly actomyosin structure organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol cell periphery plasma membrane membrane endosome intracellular vesicle macropinosome endomembrane system cytoplasmic vesicle vesicle pinosome polymeric cytoskeletal fiber protein-containing complex actin filament actin cytoskeleton filamentous actin cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle intermediate filament cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002189	F-actin-capping protein subunit alpha	Family
A	IPR042489	F-actin capping protein, alpha subunit, domain 1	Homologous Superfamily
A	IPR037282	F-actin-capping protein subunit alpha/beta	Homologous Superfamily
A	IPR017865	F-actin capping protein, alpha subunit, conserved site	Conserved Site
A	IPR042276	F-actin-capping protein subunit alpha/beta, domain 2	Homologous Superfamily
B	IPR001698	F-actin-capping protein subunit beta	Family
B	IPR019771	F-actin capping protein, beta subunit, conserved site	Conserved Site
B	IPR043175	F-actin-capping protein subunit beta, N-terminal domain	Homologous Superfamily
B	IPR037282	F-actin-capping protein subunit alpha/beta	Homologous Superfamily
B	IPR042276	F-actin-capping protein subunit alpha/beta, domain 2	Homologous Superfamily
C	IPR031943	CARMIL, C-terminal domain	Domain
C	IPR041245	CARMIL, pleckstrin homology domain	Domain
C	IPR011993	PH-like domain superfamily	Homologous Superfamily
C	IPR001611	Leucine-rich repeat	Repeat
C	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.