Annotations: 2KSG

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.140.580	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF15291	Dermcidin, antibiotic peptide (Dermcidin)	Dermcidin, antibiotic peptide	Dermcidin is a family of peptides produced in the sweat to protect against pathogenic Gram-positive bacteria.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dermcidin	binding lipid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity RNA binding organic cyclic compound binding binding lipid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity RNA binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus disruption of cell in another organism response to biotic stimulus biological process involved in symbiotic interaction killing by host of symbiont cells defense response to other organism response to stress cellular process response to external biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus disruption of cell in another organism response to biotic stimulus biological process involved in symbiotic interaction killing by host of symbiont cells defense response to other organism response to stress cellular process response to external biotic stimulus disruption of anatomical structure in another organism biological process involved in interaction with symbiont killing of cells of another organism cell killing defense response to fungus response to fungus organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process defense response to bacterium response to bacterium	membrane cellular anatomical entity extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043557	Dermcidin/Lacritin	Family
A	IPR028130	Dermcidin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P81605	liver cancer Apolipoprotein A-I associated Amyloidosis liver neoplasm breast fibroadenoma psoriasis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM				Dermcidin

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.