Annotations: 2KOH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2koha1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d2koha2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e2kohA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF01049	Cadherin, Y-type LIR-motif (CADH_Y-type_LIR)	Cadherin, Y-type LIR-motif	-	Family
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Cadherin-5	protein phosphatase binding phosphatase binding protein binding binding enzyme binding cell adhesion molecule binding cadherin binding protein-containing complex binding fibrinogen binding protein tyrosine kinase binding kinase binding protein kinase binding cation binding ion binding protein phosphatase binding phosphatase binding protein binding binding enzyme binding cell adhesion molecule binding cadherin binding protein-containing complex binding fibrinogen binding protein tyrosine kinase binding kinase binding protein kinase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding signaling receptor binding BMP receptor binding receptor serine/threonine kinase binding transmembrane receptor protein serine/threonine kinase binding transmembrane transporter binding cytokine receptor binding vascular endothelial growth factor receptor binding vascular endothelial growth factor receptor 2 binding growth factor receptor binding beta-catenin binding	adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly regulation of vascular permeability multicellular organismal process system process circulatory system process vascular process in circulatory system regulation of biological quality blood circulation epithelium migration tissue migration endothelial cell migration ameboidal-type cell migration blood vessel endothelial cell migration epithelial cell migration cell migration cell motility inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cell junction assembly cell-cell junction assembly bicellular tight junction assembly tight junction organization apical junction assembly tight junction assembly developmental process anatomical structure morphogenesis anatomical structure development cell morphogenesis cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules regulation of establishment of endothelial barrier cellular developmental process regulation of developmental process positive regulation of endothelial cell development endothelium development cell development regulation of cell differentiation epithelial cell differentiation regulation of cell development regulation of epithelial cell differentiation endothelial cell development positive regulation of developmental process multicellular organism development positive regulation of cell differentiation cell differentiation regulation of endothelial cell development regulation of multicellular organismal process epithelium development regulation of multicellular organismal development endothelial cell differentiation regulation of endothelial cell differentiation positive regulation of cell development positive regulation of establishment of endothelial barrier tissue development epithelial cell development establishment of endothelial barrier calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules vasculature development system development circulatory system development cellular response to stimulus cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway response to stimulus cell surface receptor signaling pathway signaling cellular response to transforming growth factor beta stimulus response to endogenous stimulus cell communication cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway signal transduction enzyme-linked receptor protein signaling pathway blood vessel maturation developmental maturation anatomical structure maturation blood vessel development regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization microtubule cytoskeleton organization negative regulation of biological process microtubule polymerization or depolymerization negative regulation of cellular process negative regulation of protein polymerization negative regulation of supramolecular fiber organization protein polymerization negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization negative regulation of cytoskeleton organization regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response cell-cell adhesion mediated by cadherin positive regulation of cell communication positive regulation of signal transduction regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction positive regulation of BMP signaling pathway positive regulation of response to stimulus BMP signaling pathway cellular response to BMP stimulus regulation of signaling regulation of BMP signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway response to BMP regulation of cell communication positive regulation of signaling negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel morphogenesis tube development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion regulation of protein modification process regulation of protein phosphorylation regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process protein dephosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation positive regulation of protein dephosphorylation negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process protein localization localization cellular localization protein localization to bicellular tight junction cellular macromolecule localization macromolecule localization protein localization to cell junction protein localization to cell-cell junction regulation of establishment of cell polarity regulation of establishment or maintenance of cell polarity establishment of cell polarity establishment or maintenance of cell polarity	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane protein complex extrinsic component of membrane adherens junction membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen apical junction complex bicellular tight junction tight junction
A	Partitioning defective 3 homolog	binding phospholipid binding lipid binding phosphatidylinositol binding protein phosphatase binding phosphatase binding protein binding enzyme binding identical protein binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding binding phospholipid binding lipid binding phosphatidylinositol binding protein phosphatase binding phosphatase binding protein binding enzyme binding identical protein binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding small molecule binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3-phosphate binding	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process centrosome localization microtubule organizing center localization cell division developmental process multicellular organismal process cellular developmental process peripheral nervous system axon ensheathment peripheral nervous system development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process centrosome localization microtubule organizing center localization cell division developmental process multicellular organismal process cellular developmental process peripheral nervous system axon ensheathment peripheral nervous system development cell development nervous system development glial cell development myelination multicellular organism development neurogenesis Schwann cell development gliogenesis axon ensheathment ensheathment of neurons glial cell differentiation cell differentiation anatomical structure development myelination in peripheral nervous system Schwann cell differentiation system development establishment of cell polarity establishment of epithelial cell polarity establishment or maintenance of cell polarity establishment of protein localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane bicellular tight junction assembly tight junction organization apical junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly tight junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization cell adhesion regulation of biological process regulation of actin filament-based process regulation of cellular process actin filament-based process biological regulation regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process regulation of peptidyl-threonine phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process peptidyl-amino acid modification protein metabolic process peptidyl-threonine modification protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of peptidyl-threonine phosphorylation negative regulation of phosphorus metabolic process metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process peptidyl-threonine phosphorylation regulation of localization import into cell regulation of cellular component organization positive regulation of cellular component organization receptor internalization transport positive regulation of biological process regulation of receptor internalization vesicle-mediated transport positive regulation of endocytosis positive regulation of receptor-mediated endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport endocytosis receptor-mediated endocytosis regulation of cellular localization epithelium development actin filament-based movement tissue development cell morphogenesis epithelial cell differentiation anatomical structure morphogenesis epithelial cell development epithelial cell morphogenesis actin-mediated cell contraction apical constriction cell cycle system process regulation of developmental process regulation of myelination regulation of system process regulation of nervous system development positive regulation of myelination positive regulation of nervous system process regulation of multicellular organismal process regulation of multicellular organismal development nervous system process regulation of nervous system process positive regulation of multicellular organismal process organelle organization microtubule cytoskeleton organization microtubule-based process cytoskeleton organization cell-cell adhesion wound healing response to stimulus morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet tissue morphogenesis response to stress epiboly cell migration wound healing, spreading of cells cell motility response to wounding establishment of organelle localization organelle localization establishment of localization in cell establishment of centrosome localization establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	cell-cell junction anchoring junction cell junction cellular anatomical entity intracellular anatomical structure cytoplasm apical junction complex protein kinase complex transferase complex, transferring phosphorus-containing groups PAR polarity complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex cell-cell junction anchoring junction cell junction cellular anatomical entity intracellular anatomical structure cytoplasm apical junction complex protein kinase complex transferase complex, transferring phosphorus-containing groups PAR polarity complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex adherens junction somatodendritic compartment cell body neuronal cell body intracellular organelle cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle endomembrane system growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth cell periphery cell cortex apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane internode region of axon main axon compact myelin myelin sheath Schmidt-Lanterman incisure bicellular tight junction tight junction lateral loop

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR027397	Catenin binding domain superfamily	Homologous Superfamily
B	IPR015919	Cadherin-like superfamily	Homologous Superfamily
B	IPR039808	Cadherin	Family
B	IPR002126	Cadherin-like	Domain
B	IPR000233	Cadherin, Y-type LIR-motif	Domain
B	IPR020894	Cadherin conserved site	Conserved Site
A	IPR021922	Par3/HAL, N-terminal	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.