2KOG

lipid-bound synaptobrevin solution NMR structure

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SNARE fusion complex	8043664	3001549	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Synaptobrevin	e2kogA1	A: extended segments	X: Synaptobrevin (From Topology)	H: Synaptobrevin (From Topology)	T: Synaptobrevin	F: Synaptobrevin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00957	Synaptobrevin (Synaptobrevin)	Synaptobrevin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Vesicle-associated membrane protein 2	protein binding binding SNARE binding syntaxin binding phospholipid binding lipid binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding calmodulin binding identical protein binding syntaxin-1 binding transmembrane transporter binding protein binding binding SNARE binding syntaxin binding phospholipid binding lipid binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding calmodulin binding identical protein binding syntaxin-1 binding transmembrane transporter binding cytoskeletal protein binding myosin binding calcium-dependent protein binding	protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane organic substance transport localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport regulated exocytosis secretion export from cell secretion by cell exocytosis calcium-ion regulated exocytosis membrane organization protein-containing complex organization membrane fusion organelle membrane fusion cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion multicellular organismal process response to stimulus eosinophil activation cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity myeloid leukocyte activation leukocyte activation establishment of localization in cell leukocyte activation involved in immune response eosinophil degranulation leukocyte mediated immunity eosinophil activation involved in immune response immune response cell activation myeloid cell activation involved in immune response immune effector process immune system process eosinophil mediated immunity granulocyte activation regulation of biological process signaling regulation of hormone levels biological regulation cell-cell signaling hormone secretion cell communication signal release hormone transport regulation of biological quality synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse synaptic signaling trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse anterograde trans-synaptic signaling regulation of localization regulation of cellular process regulation of protein localization positive regulation of biological process positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of transport regulation of establishment of protein localization intracellular transport regulation of protein transport positive regulation of transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport membrane docking organelle localization by membrane tethering organelle localization vesicle docking involved in exocytosis synaptic vesicle docking vesicle docking exocytic process synaptic vesicle endocytosis import into cell presynaptic endocytosis synaptic vesicle recycling endocytosis regulation of potassium ion transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of transmembrane transporter activity regulation of delayed rectifier potassium channel activity regulation of monoatomic ion transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport regulation of synaptic vesicle recycling response to hexose response to organic substance response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound regulation of vesicle-mediated transport regulation of secretion regulation of secretion by cell regulation of exocytosis cellular response to stimulus cellular response to nitrogen compound response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to insulin cellular response to organic substance cellular response to insulin stimulus cellular response to hormone stimulus protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane neurotransmitter receptor transport to plasma membrane protein localization to postsynaptic membrane neurotransmitter receptor transport exocytic insertion of neurotransmitter receptor to postsynaptic membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse positive regulation of cell communication modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity regulation of signaling positive regulation of synaptic transmission regulation of trans-synaptic signaling regulation of cell communication positive regulation of signaling	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex storage vacuole vacuole perinuclear region of cytoplasm zymogen granule zymogen granule membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane secretory granule membrane synapse transport vesicle membrane presynapse synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane exocytic vesicle synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon terminal bouton neuron projection terminus clathrin-coated vesicle coated vesicle cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016444	Synaptobrevin/Vesicle-associated membrane protein	Family
A	IPR042855	v-SNARE, coiled-coil homology domain	Domain
A	IPR001388	Synaptobrevin-like	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM				SNARE complex

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	SNARE Protein Family	Synaptobrevin, lipid-bound

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.