Annotations: 2KOE

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1220.70	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	human cannabinoid receptor 1 - helix 7/8 peptide	identical protein binding protein binding binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity cannabinoid receptor activity	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process biological regulation mating behavior developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process biological regulation mating behavior behavior reproductive behavior regulation of multicellular organismal process penile erection copulation positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process system process learning or memory nervous system process cognition memory monoamine transport regulation of localization nitrogen compound transport negative regulation of amine transport transport signaling regulation of catecholamine secretion negative regulation of biological process negative regulation of transport organic hydroxy compound transport dopamine transport cell communication localization secretion by cell regulation of secretion by cell negative regulation of secretion catecholamine transport negative regulation of dopamine secretion signal release negative regulation of cellular process negative regulation of secretion by cell secretion regulation of transport organic substance transport export from cell cell-cell signaling negative regulation of catecholamine secretion dopamine secretion establishment of localization regulation of secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis system development plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization metabolic process regulation of metabolic process protein localization establishment of protein localization cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion regulation of protein secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion hormone secretion protein localization to extracellular region peptide secretion amide transport regulation of signaling regulation of peptide transport regulation of establishment of protein localization regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion positive regulation of acute inflammatory response to antigenic stimulus regulation of defense response regulation of acute inflammatory response to antigenic stimulus response to stimulus regulation of response to external stimulus positive regulation of acute inflammatory response inflammatory response to antigenic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response positive regulation of immune response response to stress regulation of response to stress regulation of immune system process acute inflammatory response positive regulation of immune system process defense response immune response regulation of inflammatory response to antigenic stimulus response to external stimulus regulation of inflammatory response positive regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus regulation of response to stimulus immune system process positive regulation of defense response regulation of acute inflammatory response regulation of immune response inflammatory response neuron recognition neuron projection fasciculation axonal fasciculation cell recognition axon development inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration regulation of presynaptic cytosolic calcium ion concentration cellular homeostasis neuron cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of behavior feeding behavior regulation of feeding behavior glucose homeostasis carbohydrate homeostasis cellular response to stimulus G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway signal transduction cannabinoid signaling pathway negative regulation of monoatomic ion transport monoatomic ion transport serotonin secretion negative regulation of serotonin secretion regulation of monoatomic ion transport serotonin transport regulation of serotonin secretion trans-synaptic signaling synaptic transmission, GABAergic modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of synaptic transmission, GABAergic multi-multicellular organism process maternal process involved in female pregnancy female pregnancy multi-organism reproductive process circulatory system process regulation of blood pressure positive regulation of blood pressure blood circulation adenylate cyclase-modulating G protein-coupled receptor signaling pathway trans-synaptic signaling, modulating synaptic transmission trans-synaptic signaling by endocannabinoid trans-synaptic signaling by lipid, modulating synaptic transmission trans-synaptic signaling by lipid trans-synaptic signaling by endocannabinoid, modulating synaptic transmission response to organic substance response to alcohol response to chemical response to oxygen-containing compound response to ethanol adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of action potential negative regulation of action potential action potential regulation of membrane potential retrograde trans-synaptic signaling retrograde trans-synaptic signaling by endocannabinoid retrograde trans-synaptic signaling by lipid regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation negative regulation of mast cell activation negative regulation of immune system process mast cell activation regulation of mast cell activation negative regulation of multicellular organismal process negative regulation of leukocyte activation synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic response to nutrient levels response to nutrient response to nicotine biological process involved in interspecies interaction between organisms response to lipid response to other organism response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin response to organonitrogen compound response to nitrogen compound response to organic cyclic compound response to cocaine response to alkaloid acute-phase response regulation of heat generation positive regulation of heat generation heat generation positive regulation of fever generation fever generation multicellular organismal-level homeostasis temperature homeostasis positive regulation of multicellular organismal process regulation of fever generation negative regulation of blood pressure negative regulation of small molecule metabolic process negative regulation of fatty acid beta-oxidation oxoacid metabolic process regulation of lipid metabolic process organic acid catabolic process organic acid metabolic process cellular lipid catabolic process negative regulation of cellular metabolic process regulation of primary metabolic process cellular catabolic process regulation of fatty acid oxidation monocarboxylic acid catabolic process cellular ketone metabolic process regulation of small molecule metabolic process carboxylic acid catabolic process small molecule metabolic process negative regulation of lipid catabolic process regulation of cellular ketone metabolic process cellular metabolic process negative regulation of metabolic process regulation of fatty acid beta-oxidation regulation of cellular metabolic process primary metabolic process regulation of lipid catabolic process cellular lipid metabolic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process small molecule catabolic process negative regulation of lipid metabolic process negative regulation of cellular catabolic process catabolic process negative regulation of fatty acid oxidation organic substance metabolic process fatty acid oxidation fatty acid beta-oxidation lipid oxidation negative regulation of catabolic process fatty acid metabolic process lipid catabolic process negative regulation of fatty acid metabolic process carboxylic acid metabolic process lipid modification regulation of catabolic process fatty acid catabolic process regulation of cellular catabolic process organic substance catabolic process lipid metabolic process	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle cell periphery presynapse synapse cell junction membrane plasma membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle cell periphery presynapse synapse cell junction membrane plasma membrane presynaptic membrane plasma membrane region synaptic membrane cytoplasm glutamatergic synapse membrane-bounded organelle mitochondrial membrane mitochondrion organelle outer membrane intracellular membrane-bounded organelle organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane membrane microdomain membrane raft growth cone axon cell projection distal axon neuron projection plasma membrane bounded cell projection site of polarized growth GABA-ergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000810	Cannabinoid receptor type 1	Family
A	IPR002230	Cannabinoid receptor family	Family
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P21554	obesity disorder cannabis dependence pancreatitis rhabdomyosarcoma status epilepticus Huntington disease Pain temporal lobe epilepsy cocaine abuse visual epilepsy endometriosis substance withdrawal syndrome cirrhosis of liver cocaine dependence multiple sclerosis obesity disorder cannabis dependence pancreatitis rhabdomyosarcoma status epilepticus Huntington disease Pain temporal lobe epilepsy cocaine abuse visual epilepsy endometriosis substance withdrawal syndrome cirrhosis of liver cocaine dependence multiple sclerosis schizophrenia cutaneous melanoma lung adenocarcinoma malignant colon neoplasm bipolar disorder malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm medulloblastoma common cold depressive disorder anxiety disorder drug dependence oligodendroglioma attention deficit hyperactivity disorder, inattentive type ovarian cancer large cell medulloblastoma binge eating disorder lung cancer malignant ependymoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia monogenic obesity psoriasis Alzheimer disease interstitial cystitis ductal breast carcinoma in situ atypical teratoid rhabdoid tumor substance dependence substance-related disorder major depressive disorder pancreatic intraductal papillary-mucinous carcinoma pancreatic neoplasm glioblastoma migraine disorder pituitary cancer tuberculosis movement disorder adenoma allergic rhinitis hypotensive disorder non-small cell lung carcinoma astrocytic tumor invasive ductal breast carcinoma osteosarcoma substance abuse juvenile Huntington disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.