2KKZ

Solution NMR structure of the monomeric W187R mutant of A/Udorn NS1 effector domain. Northeast Structural Genomics target OR8C[W187R].

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2kkza1	Alpha and beta proteins (a+b)	Ns1 effector domain-like	Ns1 effector domain-like	Ns1 effector domain-like	automated matches	(Influenza A virus (A/Hungary/2/1971(H3N2)) ) [TaxId: 221021 ],	SCOPe (2.08)
A	d2kkza2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Influenza A virus (A/Hungary/2/1971(H3N2)) ) [TaxId: 221021 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ns1 effector domain-like	8086490	3000759	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Flu_NS1_C	e2kkzA1	A: mixed a+b and a/b	X: Ns1 effector domain-like (From Topology)	H: Ns1 effector domain-like (From Topology)	T: Ns1 effector domain-like	F: Flu_NS1_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.420.330	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00600	Influenza non-structural protein (NS1) (Flu_NS1)	Influenza non-structural protein (NS1)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Non-structural protein NS1	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity identical protein binding protein binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response modulation by symbiont of host process symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism symbiont-mediated perturbation of host defenses response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response modulation by symbiont of host process response to host immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus modulation of process of another organism symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host PKR/eIFalpha signaling symbiont-mediated perturbation of host translation symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host-directed shutoff of host translation symbiont-mediated perturbation of host gene expression cellular process symbiont-mediated perturbation of host signal transduction pathway cellular localization transport intracellular transport establishment of localization symbiont-mediated perturbation of host intracellular transport localization establishment of localization in cell symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway multicellular organismal process regulation of cellular process negative regulation of biological process modulation by virus of host process negative regulation of cellular metabolic process organic substance biosynthetic process cytokine production regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process cellular biosynthetic process virus-mediated perturbation of host defense response perturbation by virus of host immune response organic substance metabolic process negative regulation of cellular process regulation of cytokine production viral process regulation of multicellular organismal process negative regulation of macromolecule metabolic process modulation by virus of host cellular process regulation of biosynthetic process suppression by virus of host cytokine production biological regulation negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process modulation by virus of host cytokine production symbiont-mediated suppression of host cytokine production symbiont-mediated suppression of host mRNA processing symbiont-mediated suppression of host gene expression	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038064	Influenza A virus NS1, effector domain-like superfamily	Homologous Superfamily
A	IPR009068	uS15/NS1, RNA-binding domain superfamily	Homologous Superfamily
A	IPR000256	Influenza A virus NS1 protein	Family
A	IPR004208	Influenza non-structural protein (NS1)	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.