2KCD

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SAUGI	8047765	4005804	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Uracil-DNA glycosylase inhibitor protein	8054184	3000500	SCOP2 (2022-06-29)

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06106	e2kcdA1	A: a+b two layers	X: Cystatin-like	H: Uncharacterized protein SSP0047 (From Topology)	T: Uncharacterized protein SSP0047	F: PF06106	ECOD (1.6)

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.250	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Chains	Accession	Name	Description	Comments	Source
A	PF06106	S. aureus uracil DNA glycosylase inhibitor (SAUGI)	S. aureus uracil DNA glycosylase inhibitor	Uracil-DNA glycosylase inhibitors, are DNA mimic proteins that prevent the DNA binding sites of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate. SSP0047 Swiss:Q4A134 (or SAUGI; for Staphylococcus aureus uracil-DNA glycosylase ...	Uracil-DNA glycosylase inhibitors, are DNA mimic proteins that prevent the DNA binding sites of UDGs (Uracil DNA glycosylase) from interacting with their DNA substrate. SSP0047 Swiss:Q4A134 (or SAUGI; for Staphylococcus aureus uracil-DNA glycosylase inhibitor) acts as a uracil-DNA glycosylase inhibitor that breaks the uracil-removing activity of S. aureus uracil-DNA glycosylase (SAUDG) Pfam:PF03167 [1]. The SAUGI/SAUDG complex has been determined, and shows that SAUGI binds to the SAUDG DNA binding region via several strong interactions, by using a hydrophobic pocket to hold SAUDG's protruding residue (i.e. SAUDG Leu184, E. coli UDG Leu191 and B. subtilis UDG Phe191). By binding to SAUDG in this way, SAUGI thus prevents SAUDG from binding to its DNA substrate and performing DNA repair activity [2].	Domain