2KA6

NMR structure of the CBP-TAZ2/STAT1-TAD complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ka6a_	Small proteins	TAZ domain	TAZ domain	TAZ domain	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	TAZ domain	8039358	3001533	SCOP2B (2022-06-29)
B	SCOP2 Family	STAT1-TAD	8047292	4005553	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	STAT1-TAD	8104090	3002819	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	zf-TAZ	e2ka6A1	A: few secondary structure elements	X: TAZ domain (From Topology)	H: TAZ domain (From Topology)	T: TAZ domain	F: zf-TAZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1020.10	Mainly Alpha	Up-down Bundle	CREB-binding Protein	Chain A	CATH (4.3.0)
B	6.10.250.3310	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	signal transducer and activator of transcription 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02135	TAZ zinc finger (zf-TAZ)	TAZ zinc finger	-	Family
B	PF12162	STAT1 TAZ2 binding domain (STAT1_TAZ2bind)	STAT1 TAZ2 binding domain	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CREB-binding protein	transcription factor binding basal transcription machinery binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding TFIIB-class transcription factor binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding signaling receptor binding peroxisome proliferator activated receptor binding acetyltransferase activity transcription factor binding basal transcription machinery binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding TFIIB-class transcription factor binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding signaling receptor binding peroxisome proliferator activated receptor binding acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity DNA binding organic cyclic compound binding nucleic acid binding protein-containing complex binding molecular adaptor activity catalytic activity, acting on a protein N-acetyltransferase activity histone H3 acetyltransferase activity peptide N-acetyltransferase activity histone H3K27 acetyltransferase activity histone acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity N-acyltransferase activity p53 binding protein domain specific binding cAMP response element binding protein binding RNA polymerase II-specific DNA-binding transcription factor binding chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity damaged DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding histone H3K18 acetyltransferase activity transcription corepressor activity transcription coregulator binding transcription coactivator binding SMAD binding chromatin DNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding disordered domain specific binding	organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process protein destabilization regulation of protein stability biological regulation regulation of biological quality developmental process multicellular organismal process organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process protein destabilization regulation of protein stability biological regulation regulation of biological quality developmental process multicellular organismal process germ-line stem cell population maintenance maintenance of cell number stem cell population maintenance regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process cellular process regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus negative regulation of viral process regulation of viral process viral process negative regulation of biological process positive regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development cell development regulation of dendritic spine development neuron projection development cellular component organization positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development signaling non-canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization adult behavior response to organic substance response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to alkaloid behavior behavioral response to cocaine response to chemical response to organic cyclic compound response to cocaine anatomical structure morphogenesis head development face morphogenesis head morphogenesis face development body morphogenesis positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling peptidyl-lysine acetylation N-terminal peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein maturation peptidyl-amino acid modification N-terminal protein amino acid acetylation protein acetylation N-terminal protein amino acid modification negative regulation of type I interferon production cytokine production regulation of cytokine production regulation of multicellular organismal process regulation of interferon-beta production interferon-beta production type I interferon production negative regulation of cytokine production negative regulation of gene expression negative regulation of interferon-beta production negative regulation of multicellular organismal process regulation of type I interferon production system process learning or memory long-term memory nervous system process cognition memory positive regulation of cell adhesion molecule production regulation of cell adhesion molecule production cell adhesion molecule production rhythmic process response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV regulation of non-canonical NF-kappaB signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction positive regulation of non-canonical NF-kappaB signal transduction response to hepatocyte growth factor cellular response to hepatocyte growth factor stimulus transcription by RNA polymerase I regulation of transcription by RNA polymerase I negative regulation of transcription by RNA polymerase I cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus	protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region outer kinetochore condensed chromosome, centromeric region protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region outer kinetochore condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-DNA complex chromatin catalytic complex transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body PML body
B	Signal transducer and activator of transcription 1-alpha/beta	CCR5 chemokine receptor binding CCR chemokine receptor binding protein binding binding signaling receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding histone binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity CCR5 chemokine receptor binding CCR chemokine receptor binding protein binding binding signaling receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding histone binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity cell adhesion molecule binding cadherin binding DNA binding sequence-specific DNA binding double-stranded DNA binding core promoter sequence-specific DNA binding nucleic acid binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding identical protein binding transcription factor binding transcription coregulator binding transcription corepressor binding protein phosphatase binding phosphatase binding enzyme binding protein phosphatase 2A binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding ubiquitin-like protein ligase binding protein homodimerization activity protein dimerization activity transcription coactivator binding histone acetyltransferase binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding	response to stimulus response to chemical response to xenobiotic stimulus multicellular organismal process kidney epithelium development regulation of cellular process negative regulation of biological process regulation of kidney development metanephric nephron tubule epithelial cell differentiation regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation multicellular organism development metanephros development response to stimulus response to chemical response to xenobiotic stimulus multicellular organismal process kidney epithelium development regulation of cellular process negative regulation of biological process regulation of kidney development metanephric nephron tubule epithelial cell differentiation regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation multicellular organism development metanephros development cell differentiation anatomical structure development regulation of epithelial cell differentiation involved in kidney development regulation of nephron tubule epithelial cell differentiation nephron development system development developmental process epithelium development regulation of biological process metanephric nephron tubule development tissue development nephron tubule epithelial cell differentiation negative regulation of nephron tubule epithelial cell differentiation metanephric tubule development negative regulation of multicellular organismal process cellular developmental process regulation of developmental process negative regulation of epithelial cell differentiation involved in kidney development metanephric epithelium development nephron tubule development renal system development negative regulation of kidney development negative regulation of metanephric nephron tubule epithelial cell differentiation renal tubule development negative regulation of cellular process regulation of multicellular organismal process negative regulation of cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation metanephric nephron epithelium development nephron epithelium development epithelial cell differentiation involved in kidney development regulation of multicellular organismal development negative regulation of epithelial cell differentiation tube development negative regulation of developmental process animal organ development biological regulation cell differentiation involved in metanephros development cell differentiation involved in kidney development cellular process kidney development regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus response to interferon-beta response to organic substance response to cytokine cellular response to interferon-beta cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance cell population proliferation kidney mesenchymal cell proliferation metanephric mesenchyme development metanephric mesenchymal cell proliferation involved in metanephros development mesenchyme development cell proliferation involved in kidney development kidney mesenchyme development cell proliferation involved in metanephros development mesenchymal cell proliferation defense response response to stress biological process involved in interspecies interaction between organisms immune response response to other organism response to type II interferon defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus signaling cytokine-mediated signaling pathway cellular response to type II interferon cell communication interferon-mediated signaling pathway signal transduction cell surface receptor signaling pathway type II interferon-mediated signaling pathway homeostatic process positive regulation of biological process cell development regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process myeloid cell homeostasis positive regulation of cellular process erythrocyte homeostasis hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus regulation of defense response to virus defense response to virus regulation of response to stimulus regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to virus response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP response to organic cyclic compound negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process response to interleukin-9 interleukin-9-mediated signaling pathway cellular response to interleukin-9 response to hydrogen peroxide response to oxidative stress response to reactive oxygen species response to inorganic substance positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process interferon-alpha production cytokine production regulation of cytokine production regulation of interferon-alpha production positive regulation of type I interferon production type I interferon production positive regulation of interferon-alpha production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production regulation of type I interferon production cellular response to organic cyclic compound cellular response to type I interferon type I interferon-mediated signaling pathway response to type I interferon response to hormone response to endogenous stimulus response to peptide hormone negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction renal vesicle morphogenesis metanephros morphogenesis animal organ morphogenesis nephron morphogenesis nephron epithelium morphogenesis regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric renal vesicle morphogenesis renal vesicle development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric nephron development mesenchymal to epithelial transition involved in metanephros morphogenesis mesenchymal to epithelial transition morphogenesis of an epithelium metanephric nephron morphogenesis tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis regulation of viral process negative regulation of viral process regulation by virus of viral protein levels in host cell viral process regulation of biological quality negative regulation by virus of viral protein levels in host cell positive regulation of mesenchymal cell proliferation regulation of mesenchymal cell proliferation regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process metanephric mesenchymal cell differentiation mesenchymal cell differentiation involved in kidney development mesenchymal cell differentiation involved in renal system development mesenchymal cell differentiation response to mechanical stimulus response to abiotic stimulus interleukin-27-mediated signaling pathway foam cell differentiation macrophage derived foam cell differentiation cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT cellular response to nitrogen compound cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to organonitrogen compound response to insulin cellular response to insulin stimulus cellular response to hormone stimulus angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis negative regulation of blood vessel morphogenesis negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis response to nutrient levels response to nutrient negative regulation of cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation system process circulatory system process blood circulation	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ISGF3 complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ISGF3 complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle perinuclear region of cytoplasm axon membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
A	IPR018359	Bromodomain, conserved site	Conserved Site
A	IPR036529	Coactivator CBP, KIX domain superfamily	Homologous Superfamily
A	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
A	IPR000197	Zinc finger, TAZ-type	Domain
A	IPR000433	Zinc finger, ZZ-type	Domain
A	IPR003101	Coactivator CBP, KIX domain	Domain
A	IPR013178	Histone acetyltransferase Rtt109/CBP	Family
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A	IPR010303	CREB-binding protein/p300, atypical RING domain	Domain
A	IPR001487	Bromodomain	Domain
A	IPR035898	TAZ domain superfamily	Homologous Superfamily
A	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Homologous Superfamily
A	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking	Domain
A	IPR038547	CBP/p300, atypical RING domain superfamily	Homologous Superfamily
A	IPR031162	CBP/p300-type histone acetyltransferase domain	Domain
B	IPR035859	STAT1, SH2 domain	Domain
B	IPR048988	Signal transducer and activator of transcription, linker domain	Domain
B	IPR036535	STAT transcription factor, N-terminal domain superfamily	Homologous Superfamily
B	IPR013800	STAT transcription factor, all-alpha domain	Domain
B	IPR038295	STAT1, C-terminal domain superfamily	Homologous Superfamily
B	IPR036860	SH2 domain superfamily	Homologous Superfamily
B	IPR022752	Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal	Domain
B	IPR000980	SH2 domain	Domain
B	IPR001217	Transcription factor STAT	Family
B	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B	IPR013799	STAT transcription factor, protein interaction	Domain
B	IPR015988	STAT transcription factor, coiled coil	Homologous Superfamily
B	IPR013801	STAT transcription factor, DNA-binding	Domain
B	IPR012345	STAT transcription factor, DNA-binding, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P42224	immunodeficiency 31B chronic mucocutaneous candidiasis mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome rheumatoid arthritis cytomegalovirus infection mycobacterial infectious disease hearing loss disorder Neoplasm Metastasis cirrhosis of liver systemic lupus erythematosus ulcerative colitis Sjogren syndrome Crohn disease hepatocellular carcinoma immunodeficiency 31B chronic mucocutaneous candidiasis mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome rheumatoid arthritis cytomegalovirus infection mycobacterial infectious disease hearing loss disorder Neoplasm Metastasis cirrhosis of liver systemic lupus erythematosus ulcerative colitis Sjogren syndrome Crohn disease hepatocellular carcinoma influenza tuberculosis lung disease exocrine pancreatic carcinoma medulloblastoma glioblastoma Alzheimer disease herpes zoster ovarian cancer autoimmune disease pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma breast cancer intellectual disability progressive supranuclear palsy celiac disease juvenile dermatomyositis sarcoidosis limb-girdle muscular dystrophy cystic fibrosis lung cancer dermatomyositis malignant ependymoma ductal breast carcinoma in situ malignant pancreatic neoplasm Hashimoto thyroiditis myositis hematologic disease non-small cell lung carcinoma atopic eczema hydrolethalus syndrome pancreatic ductal adenocarcinoma inflammatory bowel disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast carcinoma interstitial cystitis psoriasis juvenile idiopathic arthritis systemic sclerosis lung carcinoma malignant glioma esophageal adenocarcinoma MALT lymphoma Gaucher disease multiple sclerosis head and neck cancer nasopharyngeal carcinoma osteosarcoma atypical teratoid rhabdoid tumor hypothyroidism pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma bacterial infectious disease with sepsis primary biliary cholangitis cancer invasive ductal breast carcinoma chronic obstructive pulmonary disease large cell medulloblastoma skin disease cutaneous lupus erythematosus lung adenocarcinoma