Annotations: 2K7M

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Connexin 40 C-terminal domain-like	8046156	4004915	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Connexin C-terminal domain-like	8092987	3001780	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16791	e2k7mA1	A: extended segments	X: Connexin43 (From Topology)	H: Connexin43 (From Topology)	T: Connexin43	F: PF16791	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16791	Connexin 40 C-terminal domain (Connexin40_C)	Connexin 40 C-terminal domain	This is the C-terminal domain of connexin 40. It interacts with the C-terminal and cytoplasmic loop domains of connexin 43 and with the cytoplasmic loop pf connexin 40 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Gap junction alpha-5 protein	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling wide pore channel activity gap junction channel activity involved in cardiac conduction electrical coupling passive transmembrane transporter activity channel activity transporter activity gap junction channel activity involved in cell communication by electrical coupling gap junction channel activity transmembrane transporter activity gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling gap junction hemi-channel activity gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling protein binding binding gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling wide pore channel activity gap junction channel activity involved in cardiac conduction electrical coupling passive transmembrane transporter activity channel activity transporter activity gap junction channel activity involved in cell communication by electrical coupling gap junction channel activity transmembrane transporter activity gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling gap junction hemi-channel activity gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling protein binding binding connexin binding disordered domain specific binding protein domain specific binding	protein localization regulation of systemic arterial blood pressure by renin-angiotensin multicellular organismal process regulation of localization regulation of systemic arterial blood pressure by hormone system process establishment of protein localization nitrogen compound transport regulation of cellular process regulation of renal system process regulation of system process cell communication localization circulatory system process renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure protein localization regulation of systemic arterial blood pressure by renin-angiotensin multicellular organismal process regulation of localization regulation of systemic arterial blood pressure by hormone system process establishment of protein localization nitrogen compound transport regulation of cellular process regulation of renal system process regulation of system process cell communication localization circulatory system process renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure cellular macromolecule localization regulation of biological quality regulation of biological process organic substance transport establishment of protein localization to extracellular region regulation of systemic arterial blood pressure by circulatory renin-angiotensin protein secretion establishment of localization regulation of protein secretion regulation of secretion regulation of endocrine process renin secretion into blood stream cellular localization regulation of systemic arterial blood pressure mediated by a chemical signal regulation of protein localization transport signaling protein localization to extracellular region regulation of secretion by cell secretion by cell regulation of renin secretion into blood stream signal release regulation of multicellular organismal process renal system process involved in regulation of systemic arterial blood pressure blood circulation renal system process regulation of transport secretion regulation of blood pressure biological regulation regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport endocrine process regulation of systemic arterial blood pressure protein transport regulation of cellular localization macromolecule localization cellular process heart process bundle of His cell to Purkinje myocyte communication bundle of His cell to Purkinje myocyte communication by electrical coupling regulation of heart contraction cell communication by electrical coupling involved in cardiac conduction cell communication by electrical coupling regulation of blood circulation cardiac conduction cell communication involved in cardiac conduction heart contraction developmental process heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development cardiac chamber morphogenesis heart morphogenesis ventricular septum development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development AV node cell to bundle of His cell communication regulation of membrane depolarization membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization regulation of membrane potential tissue remodeling atrial ventricular junction remodeling regulation of tube diameter regulation of tube size positive regulation of biological process positive regulation of vasoconstriction vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size regulation of atrial cardiac muscle cell membrane depolarization skeletal system development cardiac muscle cell membrane repolarization membrane repolarization regulation of membrane repolarization ventricular cardiac muscle cell membrane repolarization regulation of cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of AV node cell action potential AV node cell action potential cell-cell signaling involved in cardiac conduction regulation of cardiac muscle cell action potential regulation of action potential AV node cell to bundle of His cell signaling action potential regulation of cell communication cardiac muscle cell action potential blood vessel morphogenesis tube development artery development vasculature development tube morphogenesis artery morphogenesis blood vessel development AV node cell to bundle of His cell communication by electrical coupling cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly gap junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization epithelium development endothelium development tissue development septum primum development cardiac atrium development atrial septum development regulation of membrane depolarization during cardiac muscle cell action potential membrane depolarization during action potential membrane depolarization during cardiac muscle cell action potential regulation of membrane depolarization during action potential cell communication by chemical coupling vasomotion cardiac muscle contraction actin filament-based process cardiac muscle cell contraction regulation of cardiac muscle contraction muscle contraction regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of atrial cardiac muscle cell action potential cardiac muscle cell action potential involved in contraction regulation of actin filament-based process regulation of cardiac conduction atrial cardiac muscle cell to AV node cell signaling striated muscle contraction atrial cardiac muscle cell to AV node cell communication atrial cardiac muscle cell action potential actin filament-based movement muscle system process regulation of muscle system process regulation of cardiac muscle cell contraction actin-mediated cell contraction regulation of heart rate by cardiac conduction regulation of heart rate ventricular cardiac muscle cell action potential atrioventricular valve development heart valve development mitral valve development pulmonary valve morphogenesis pulmonary valve formation pulmonary valve development heart valve morphogenesis anatomical structure formation involved in morphogenesis semi-lunar valve development heart valve formation regulation of cell communication by electrical coupling cardiac atrium morphogenesis atrial septum morphogenesis Purkinje myocyte to ventricular cardiac muscle cell communication Purkinje myocyte action potential regulation of Purkinje myocyte action potential Purkinje myocyte to ventricular cardiac muscle cell signaling angiogenesis embryo development embryonic heart tube development embryonic organ development positive regulation of cell communication regulation of cell communication by chemical coupling positive regulation of cell communication by chemical coupling positive regulation of cellular process SA node cell to atrial cardiac muscle cell signaling SA node cell to atrial cardiac muscle cell communication SA node cell action potential limb development appendage development embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis appendage morphogenesis limb morphogenesis regulation of body fluid levels negative regulation of biological process negative regulation of glomerular filtration regulation of glomerular filtration renal system process involved in regulation of blood volume negative regulation of multicellular organismal process glomerular filtration renal filtration monoatomic ion transport potassium ion transport monoatomic cation transport metal ion transport vasodilation cardiac conduction system development cardiac muscle tissue development striated muscle tissue development muscle tissue development regulation of bundle of His cell action potential bundle of His cell to Purkinje myocyte signaling bundle of His cell action potential atrial cardiac muscle cell to AV node cell communication by electrical coupling negative regulation of blood pressure foramen ovale closure outflow tract morphogenesis	cell-cell junction intercalated disc anchoring junction cell junction cellular anatomical entity cell-cell contact zone protein-containing complex plasma membrane protein complex gap junction membrane plasma membrane membrane protein complex cell periphery connexin complex cell-cell junction intercalated disc anchoring junction cell junction cellular anatomical entity cell-cell contact zone protein-containing complex plasma membrane protein complex gap junction membrane plasma membrane membrane protein complex cell periphery connexin complex cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002264	Gap junction alpha-5 protein (Cx40)	Family
A	IPR034634	Connexin, C-terminal	Homologous Superfamily
A	IPR017990	Connexin, conserved site	Conserved Site
A	IPR031862	Gap junction alpha-5 protein (Cx40), C-terminal	Domain
A	IPR038359	Connexin, N-terminal domain superfamily	Homologous Superfamily
A	IPR000500	Connexin	Family
A	IPR019570	Gap junction protein, cysteine-rich domain	Domain
A	IPR013092	Connexin, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.