Annotations: 2K2O

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2k2oA1	A: beta complex topology	X: Myoferlin inner DysF domain (From Topology)	H: Myoferlin inner DysF domain (From Topology)	T: Myoferlin inner DysF domain	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Myoferlin	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipid binding lipid binding	regulation of localization cellular localization regulation of cellular process transport modulation of chemical synaptic transmission signaling cell communication localization synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling regulation of localization cellular localization regulation of cellular process transport modulation of chemical synaptic transmission signaling cell communication localization synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling regulation of biological process regulation of signaling neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport biological regulation export from cell cell-cell signaling neurotransmitter transport establishment of localization regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of cell communication cellular process multicellular organismal process system process muscle contraction muscle system process membrane organization wound healing response to stimulus plasma membrane repair cellular component organization response to stress plasma membrane organization cellular component organization or biogenesis response to wounding endomembrane system organization circulatory system process blood circulation	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane extracellular exosome membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle centrosome microtubule organizing center cytoskeleton centriolar satellite intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane microdomain cell periphery membrane raft plasma membrane raft plasma membrane plasma membrane region caveola cytoplasmic vesicle intracellular vesicle cytoplasm synapse transport vesicle membrane presynapse bounding membrane of organelle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR037723	Ferlin, fourth C2 domain	Domain
A	IPR012560	Ferlin A-domain	Domain
A	IPR006614	Peroxin/Ferlin domain	Domain
A	IPR037721	Ferlin family	Family
A	IPR037724	Ferlin, fifth C2 domain	Domain
A	IPR037722	Ferlin, third C2 domain	Domain
A	IPR012968	FerIin domain	Domain
A	IPR000008	C2 domain	Domain
A	IPR012561	Ferlin B-domain	Domain
A	IPR037725	Ferlin, sixth C2 domain	Domain
A	IPR032362	Ferlin, C-terminal domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR037726	Ferlin, first C2 domain	Domain
A	IPR037720	Ferlin, second C2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NZM1	malignant glioma MALT lymphoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm adenoma pituitary cancer atypical teratoid rhabdoid tumor tuberculosis chronic kidney disease diabetes mellitus facioscapulohumeral muscular dystrophy limb-girdle muscular dystrophy lung carcinoma malignant mesothelioma myopathy malignant glioma MALT lymphoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm adenoma pituitary cancer atypical teratoid rhabdoid tumor tuberculosis chronic kidney disease diabetes mellitus facioscapulohumeral muscular dystrophy limb-girdle muscular dystrophy lung carcinoma malignant mesothelioma myopathy pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia amyotrophic lateral sclerosis psoriasis Becker muscular dystrophy ulcerative colitis Crohn disease Duchenne muscular dystrophy glioblastoma lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma astrocytic tumor subependymal giant cell astrocytoma breast cancer dermatomyositis Emery-Dreifuss muscular dystrophy juvenile dermatomyositis lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.