2K2C

Solution NMR structure of N-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2k2ca1	Small proteins	CHY zinc finger-like	CHY zinc finger-like	CHY zinc finger	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2k2ca2	Small proteins	Zinc hairpin stack	Zinc hairpin stack	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG1940	e2k2cA2	A: few secondary structure elements	X: Zinc hairpin stack (From Topology)	H: Zinc hairpin stack (From Topology)	T: Zinc hairpin stack	F: KOG1940	ECOD (1.6)
A	zf-CHY	e2k2cA1	A: few secondary structure elements	X: CHY zinc finger (From Topology)	H: CHY zinc finger (From Topology)	T: CHY zinc finger	F: zf-CHY	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05495	CHY zinc finger (zf-CHY)	CHY zinc finger	This family of domains are likely to bind to zinc ions. They contain many conserved cysteine and histidine residues. We have named this domain after the N-terminal motif CXHY. This domain can be found in isolation in some proteins, but is also often ...	This family of domains are likely to bind to zinc ions. They contain many conserved cysteine and histidine residues. We have named this domain after the N-terminal motif CXHY. This domain can be found in isolation in some proteins, but is also often associated with Pfam:PF00097. One of the proteins in this family (Swiss:P36078) is a mitochondrial intermembrane space protein called Hot13. This protein is involved in the assembly of small TIM complexes [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RING finger and CHY zinc finger domain-containing protein 1	p53 binding protein binding binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity identical protein binding protein homodimerization activity p53 binding protein binding binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity identical protein binding protein homodimerization activity protein dimerization activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular biosynthetic process rescue of stalled ribosome organonitrogen compound biosynthetic process cellular component organization organic substance metabolic process organelle disassembly organic substance biosynthetic process cellular component organization or biogenesis protein metabolic process cellular component disassembly organonitrogen compound metabolic process ribosome disassembly cellular metabolic process primary metabolic process cellular biosynthetic process rescue of stalled ribosome organonitrogen compound biosynthetic process cellular component organization organic substance metabolic process organelle disassembly organic substance biosynthetic process cellular component organization or biogenesis protein metabolic process cellular component disassembly organonitrogen compound metabolic process ribosome disassembly cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process organelle organization biosynthetic process translational elongation cellular process metabolic process macromolecule metabolic process cellular response to stimulus postreplication repair response to stimulus DNA synthesis involved in DNA repair nucleobase-containing compound metabolic process nucleic acid biosynthetic process cellular response to stress response to stress DNA repair translesion synthesis DNA metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process error-free translesion synthesis organic cyclic compound metabolic process DNA damage response organic cyclic compound biosynthetic process DNA biosynthetic process protein autoubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process positive regulation of macromolecule metabolic process regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of metabolic process positive regulation of proteasomal protein catabolic process catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis organonitrogen compound catabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of protein catabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR037275	Zinc finger, CTCHY-type superfamily	Homologous Superfamily
A	IPR037274	Zinc finger, CHY-type superfamily	Homologous Superfamily
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR017921	Zinc finger, CTCHY-type	Domain
A	IPR039512	RCHY1, zinc-ribbon	Domain
A	IPR001841	Zinc finger, RING-type	Domain
A	IPR008913	Zinc finger, CHY-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96PM5	Disease Exacerbation plasma cell myeloma subependymal giant cell astrocytoma rheumatoid arthritis testicular germ cell tumor lung benign neoplasm ovarian cancer spina bifida

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.