Annotations: 2K1A

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.930	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Bicelle-embedded integrin alpha(iib) transmembrane segment	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF20806	Integrin alpha Ig-like domain 3 (Integrin_A_Ig_3)	Integrin alpha Ig-like domain 3	This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of an immunoglobulin-like domain.	Domain
A	PF00357	Integrin alpha cytoplasmic region (Integrin_alpha)	Integrin alpha cytoplasmic region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Integrin alpha-IIb	extracellular matrix binding binding cell adhesion molecule binding protein-containing complex binding protein binding integrin binding signaling receptor binding molecular adaptor activity fibrinogen binding cation binding ion binding metal ion binding small molecule binding identical protein binding	cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development cellular response to stimulus regulation of biological process integrin-mediated signaling pathway regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication signal transduction cell adhesion mediated by integrin positive regulation of locomotion regulation of cell motility regulation of leukocyte migration positive regulation of biological process positive regulation of leukocyte migration positive regulation of cell migration leukocyte migration immune system process regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration regulation of immune system process cell motility positive regulation of immune system process locomotion positive regulation of cellular process cell-cell adhesion	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane protein complex receptor complex integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion blood microparticle intracellular anatomical structure platelet alpha granule membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle cytoplasm organelle membrane platelet alpha granule secretory granule membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013517	FG-GAP repeat	Repeat
A	IPR013519	Integrin alpha beta-propellor	Repeat
A	IPR000413	Integrin alpha chain	Family
A	IPR048286	Integrin alpha, third immunoglobulin-like domain	Domain
A	IPR013649	Integrin alpha, first immunoglubulin-like domain	Domain
A	IPR028994	Integrin alpha, N-terminal	Homologous Superfamily
A	IPR048285	Integrin alpha, second immunoglobulin-like domain	Domain
A	IPR032695	Integrin domain superfamily	Homologous Superfamily
A	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08514	Glanzmann thrombasthenia 1 thrombocytopenia platelet-type bleeding disorder 16 carotid artery thrombosis juvenile idiopathic arthritis Liver Cirrhosis, Experimental Bernard-Soulier syndrome congenital anemia exocrine pancreatic carcinoma gastric cancer intracerebral hemorrhage malignant pancreatic neoplasm acute coronary syndrome thrombotic disease cerebrovascular disorder Glanzmann thrombasthenia 1 thrombocytopenia platelet-type bleeding disorder 16 carotid artery thrombosis juvenile idiopathic arthritis Liver Cirrhosis, Experimental Bernard-Soulier syndrome congenital anemia exocrine pancreatic carcinoma gastric cancer intracerebral hemorrhage malignant pancreatic neoplasm acute coronary syndrome thrombotic disease cerebrovascular disorder coronary artery disease gastric carcinoma medulloblastoma osteosarcoma autosomal dominant macrothrombocytopenia tuberculosis Glanzmann thrombasthenia

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM				Integrin

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.