Annotations: 2K00

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2k00a1	All beta proteins	PH domain-like barrel	PH domain-like	Third domain of FERM	Talin	Chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8043603	3000134	SCOP2B (2022-06-29)

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IRS_1	e2k00A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: IRS_1	ECOD (1.6)

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Chains	Accession	Name	Description	Comments	Source
A	PF00373	FERM central domain (FERM_M)	FERM central domain	This domain is the central structural domain of the FERM domain.	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Talin-1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cell adhesion molecule binding integrin binding signaling receptor binding structural constituent of cytoskeleton structural molecule activity	cell adhesion cell-cell adhesion cellular process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane cell surface intracellular anatomical structure cytoplasm cytosol intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle
B	Layilin	binding carbohydrate binding glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding	-	cell surface cellular anatomical entity membrane ruffle cell projection cell leading edge plasma membrane bounded cell projection

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR019748	FERM central domain	Domain
A	IPR015009	Vinculin-binding site-containing domain	Domain
A	IPR032425	Talin, N-terminal F0 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
A	IPR015224	Talin, central	Domain
A	IPR019749	Band 4.1 domain	Domain
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR036476	Talin, central domain superfamily	Homologous Superfamily
A	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A	IPR002558	I/LWEQ domain	Domain
A	IPR019747	FERM conserved site	Conserved Site
A	IPR018979	FERM, N-terminal	Domain
A	IPR049108	Talin, R4 domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR037438	Talin-1/2, rod-segment	Domain
B	IPR001304	C-type lectin-like	Domain
B	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
B	IPR016187	C-type lectin fold	Homologous Superfamily