2JZN

Solution NMR structure of the productive complex between IIAMannose and IIBMannose of the mannose transporter of the E. coli phosphotransferase system

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2jzna_	Alpha and beta proteins (a/b)	PTS system fructose IIA component-like	PTS system fructose IIA component-like	EIIA-man component-like	IIA domain of mannose transporter, IIA-Man	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2jznb_	Alpha and beta proteins (a/b)	PTS system fructose IIA component-like	PTS system fructose IIA component-like	EIIA-man component-like	IIA domain of mannose transporter, IIA-Man	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d2jznc_	Alpha and beta proteins (a/b)	PTS IIb component	PTS IIb component	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PTS system fructose IIA component-like	8044468	3000475	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PTS system fructose IIA component-like	8044468	3000475	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PTS IIb component	8079270	3000207	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03610	e2jznA1	A: a/b three-layered sandwiches	X: EDD domain (From Topology)	H: EDD domain (From Topology)	T: EDD domain	F: PF03610	ECOD (1.6)
B	PF03610	e2jznB1	A: a/b three-layered sandwiches	X: EDD domain (From Topology)	H: EDD domain (From Topology)	T: EDD domain	F: PF03610	ECOD (1.6)
C	PF03830	e2jznC1	A: a/b three-layered sandwiches	X: PTS IIb component (From Topology)	H: PTS IIb component (From Topology)	T: PTS IIb component	F: PF03830	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.510	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphotransferase system, mannose-type IIA component	CATH (4.3.0)
B	3.40.50.510	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphotransferase system, mannose-type IIA component	CATH (4.3.0)
C	3.40.35.10	Alpha Beta	3-Layer(aba) Sandwich	Fructose Permease	Phosphotransferase system, sorbose subfamily IIB component	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03610	PTS system fructose IIA component (EIIA-man)	PTS system fructose IIA component	-	Family
C	PF03830	PTS system sorbose subfamily IIB component (PTSIIB_sorb)	PTS system sorbose subfamily IIB component	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Mannose-specific phosphotransferase enzyme IIA component	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding binding protein homodimerization activity protein dimerization activity monosaccharide transmembrane transporter activity sugar transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity mannose transmembrane transporter activity hexose transmembrane transporter activity kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding binding protein homodimerization activity protein dimerization activity monosaccharide transmembrane transporter activity sugar transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity mannose transmembrane transporter activity hexose transmembrane transporter activity phosphotransferase activity, alcohol group as acceptor protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity active transmembrane transporter activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity	import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization transmembrane transport localization cellular process carbohydrate transmembrane transport phosphorylation cellular metabolic process import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization transmembrane transport localization cellular process carbohydrate transmembrane transport phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process hexose transmembrane transport monosaccharide transmembrane transport mannose transmembrane transport hexose import across plasma membrane glucose transmembrane transport glucose import across plasma membrane	membrane cellular anatomical entity protein-containing complex transmembrane transporter complex membrane protein complex transporter complex intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane
C	Mannose-specific phosphotransferase enzyme IIB component	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding binding protein homodimerization activity protein dimerization activity monosaccharide transmembrane transporter activity sugar transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity mannose transmembrane transporter activity hexose transmembrane transporter activity kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding binding protein homodimerization activity protein dimerization activity monosaccharide transmembrane transporter activity sugar transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity mannose transmembrane transporter activity hexose transmembrane transporter activity phosphotransferase activity, alcohol group as acceptor protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity active transmembrane transporter activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity	import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization transmembrane transport localization cellular process carbohydrate transmembrane transport phosphorylation cellular metabolic process import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system transport organic substance transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization transmembrane transport localization cellular process carbohydrate transmembrane transport phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process hexose transmembrane transport monosaccharide transmembrane transport mannose transmembrane transport hexose import across plasma membrane glucose transmembrane transport glucose import across plasma membrane	membrane cellular anatomical entity protein-containing complex transmembrane transporter complex membrane protein complex transporter complex intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004701	Phosphotransferase system, mannose-type IIA component	Domain
A, B	IPR036667	Phosphotransferase system, sorbose subfamily IIB component superfamily	Homologous Superfamily
A, B	IPR018455	Phosphotransferase system, sorbose subfamily IIB component, subgroup	Family
A, B	IPR036662	Phosphotransferase system, mannose-type IIA component superfamily	Homologous Superfamily
A, B	IPR004720	Phosphotransferase system, sorbose subfamily IIB component	Domain
A, B	IPR013789	Phosphotransferase system, mannose family IIA component	Domain
A, B	IPR033887	PTS system mannose/sorbose specific IIA subunit	Domain
C	IPR004701	Phosphotransferase system, mannose-type IIA component	Domain
C	IPR036667	Phosphotransferase system, sorbose subfamily IIB component superfamily	Homologous Superfamily
C	IPR018455	Phosphotransferase system, sorbose subfamily IIB component, subgroup	Family
C	IPR036662	Phosphotransferase system, mannose-type IIA component superfamily	Homologous Superfamily
C	IPR004720	Phosphotransferase system, sorbose subfamily IIB component	Domain
C	IPR013789	Phosphotransferase system, mannose family IIA component	Domain
C	IPR033887	PTS system mannose/sorbose specific IIA subunit	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.