Annotations: 2JXC

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2jxca_	All alpha proteins	EF Hand-like	EF-hand	Eps15 homology domain (EH domain)	Eps15	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Eps15 homology domain (EH domain)	8022369	4000946	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	EF-hand	8034749	3001983	SCOP2 (2022-06-29)
B	SCOP2 Family	Stonin2 NPF motifs	8047113	4005453	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Stonin2 NPF motifs	8104046	3002811	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12763	e2jxcA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF12763	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF12016	Stonin 2 (Stonin2_N)	Stonin 2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Epidermal growth factor receptor substrate 15	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding SH3 domain binding protein binding protein domain specific binding cell adhesion molecule binding cadherin binding polyubiquitin modification-dependent protein binding modification-dependent protein binding	localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host endocytosis involved in viral entry into host cell receptor-mediated endocytosis transport of virus protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization receptor internalization postsynaptic neurotransmitter receptor internalization biological regulation vesicle-mediated transport in synapse protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis establishment of localization in cell regulation of biological quality regulation of signaling regulation of biological process signaling regulation of receptor recycling positive regulation of biological process regulation of macromolecule metabolic process receptor recycling positive regulation of metabolic process organic substance metabolic process receptor metabolic process positive regulation of receptor recycling positive regulation of macromolecule metabolic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of signaling intracellular transport endosomal transport clathrin coat assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis vesicle organization organelle organization cell population proliferation regulation of cellular process regulation of cell population proliferation localization within membrane endocytic recycling vesicle-mediated transport to the plasma membrane Golgi to endosome transport post-Golgi vesicle-mediated transport cytosolic transport Golgi vesicle transport	protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm clathrin coat of coated pit apical part of cell plasma membrane region apical plasma membrane basal part of cell basal plasma membrane cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle inclusion body aggresome synapse cell junction glutamatergic synapse endosome membrane early endosome endosome intracellular vesicle early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane vesicle organelle membrane postsynapse
B	Stonin-2	cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis regulation of localization regulation of biological process regulation of cellular process regulation of cellular component organization regulation of transport biological regulation regulation of vesicle-mediated transport cellular component organization cellular component organization or biogenesis regulation of endocytosis clathrin-dependent endocytosis receptor-mediated endocytosis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol protein-containing complex vesicle coat intracellular vesicle membrane protein complex endomembrane system membrane coat cell periphery bounding membrane of organelle AP-type membrane coat adaptor complex AP-2 adaptor complex cytoplasmic vesicle vesicle membrane clathrin-coated pit clathrin-coated vesicle endocytic vesicle membrane coated vesicle clathrin vesicle coat vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin coat of coated pit clathrin coat of endocytic vesicle clathrin-coated endocytic vesicle membrane plasma membrane protein complex membrane plasma membrane coated membrane clathrin-coated endocytic vesicle clathrin coat cytoplasmic vesicle membrane coated vesicle membrane organelle membrane clathrin adaptor complex transport vesicle synapse presynapse synaptic vesicle cell junction secretory vesicle exocytic vesicle cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000261	EH domain	Domain
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR003903	Ubiquitin interacting motif	Conserved Site
B	IPR022699	Stonin-2, N-terminal	Domain
B	IPR017110	Stonin	Family
B	IPR036168	AP-2 complex subunit mu, C-terminal superfamily	Homologous Superfamily
B	IPR028565	Mu homology domain	Domain
B	IPR031228	Stonin-2, Mu homology domain	Domain
B	IPR012320	Stonin homology	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P42566	primitive neuroectodermal tumor astrocytic tumor dermatomyositis large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer pituitary cancer primitive neuroectodermal tumor astrocytic tumor dermatomyositis large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer pituitary cancer cancer invasive ductal breast carcinoma lymphoplasmacytic lymphoma malignant mesothelioma oligodendroglioma Pick disease
B	Pharos: Q8WXE9	Alcoholic Intoxication, Chronic large cell medulloblastoma osteosarcoma Pick disease schizophrenia tuberculosis atypical teratoid rhabdoid tumor malignant ependymoma ovarian cancer pilocytic astrocytoma schizophrenia 11 ulcerative colitis interstitial cystitis medulloblastoma pancreatic intraductal papillary-mucinous neoplasm Alcoholic Intoxication, Chronic large cell medulloblastoma osteosarcoma Pick disease schizophrenia tuberculosis atypical teratoid rhabdoid tumor malignant ependymoma ovarian cancer pilocytic astrocytoma schizophrenia 11 ulcerative colitis interstitial cystitis medulloblastoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.